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Body mass index, abdominal fatness, weight gain and the risk of psoriasis: a systematic review and dose-response meta-analysis of prospective studies.
Eur J Epidemiol 2018; 33(12):1163-1178EJ

Abstract

Greater body mass index (BMI) has been associated with increased risk of psoriasis in case-control and cross-sectional studies, however, the evidence from prospective studies has been limited. We conducted a systematic review and dose-response meta-analysis of different adiposity measures and the risk of psoriasis to provide a more robust summary of the evidence based on data from prospective studies. PubMed and Embase databases were searched for relevant studies up to August 8th 2017. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random effects model. The summary relative risk (RR) for a 5 unit increment in BMI was 1.19 (95% CI 1.10-1.28, I2 = 83%, n = 7). The association appeared to be stronger at higher compared to lower levels of BMI, pnonlinearity < 0.0001, and the lowest risk was observed at a BMI around 20. The summary RR was 1.24 (95% CI 1.17-1.31, I2 = 0%, pheterogeneity = 0.72, n = 3) per 10 cm increase in waist circumference, 1.37 (95% CI 1.23-1.53, I2 = 0%, pheterogeneity = 0.93, n = 3) per 0.1 unit increase in waist-to-hip ratio, and 1.11 (95% CI 1.07-1.16, I2 = 47%, pheterogeneity = 0.15, n = 3) per 5 kg of weight gain. Adiposity as measured by BMI, waist circumference, waist-to-hip ratio, and weight gain is associated with increased risk of psoriasis.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, Paddington, London, W2 1PG, UK. d.aune@imperial.ac.uk. Department of Nutrition, Bjørknes University College, Oslo, Norway. d.aune@imperial.ac.uk. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway. d.aune@imperial.ac.uk.Department of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.German Diabetes Center (DDZ), Institute for Biometrics and Epidemiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, Paddington, London, W2 1PG, UK.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, Paddington, London, W2 1PG, UK.Department of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29680995

Citation

Aune, Dagfinn, et al. "Body Mass Index, Abdominal Fatness, Weight Gain and the Risk of Psoriasis: a Systematic Review and Dose-response Meta-analysis of Prospective Studies." European Journal of Epidemiology, vol. 33, no. 12, 2018, pp. 1163-1178.
Aune D, Snekvik I, Schlesinger S, et al. Body mass index, abdominal fatness, weight gain and the risk of psoriasis: a systematic review and dose-response meta-analysis of prospective studies. Eur J Epidemiol. 2018;33(12):1163-1178.
Aune, D., Snekvik, I., Schlesinger, S., Norat, T., Riboli, E., & Vatten, L. J. (2018). Body mass index, abdominal fatness, weight gain and the risk of psoriasis: a systematic review and dose-response meta-analysis of prospective studies. European Journal of Epidemiology, 33(12), pp. 1163-1178. doi:10.1007/s10654-018-0366-z.
Aune D, et al. Body Mass Index, Abdominal Fatness, Weight Gain and the Risk of Psoriasis: a Systematic Review and Dose-response Meta-analysis of Prospective Studies. Eur J Epidemiol. 2018;33(12):1163-1178. PubMed PMID: 29680995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, abdominal fatness, weight gain and the risk of psoriasis: a systematic review and dose-response meta-analysis of prospective studies. AU - Aune,Dagfinn, AU - Snekvik,Ingrid, AU - Schlesinger,Sabrina, AU - Norat,Teresa, AU - Riboli,Elio, AU - Vatten,Lars J, Y1 - 2018/04/21/ PY - 2017/09/14/received PY - 2018/02/14/accepted PY - 2018/4/24/pubmed PY - 2019/2/12/medline PY - 2018/4/23/entrez KW - Body mass index KW - Meta-analysis KW - Psoriasis KW - Systematic review KW - Waist circumference KW - Waist-to-hip ratio KW - Weight gain SP - 1163 EP - 1178 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 33 IS - 12 N2 - Greater body mass index (BMI) has been associated with increased risk of psoriasis in case-control and cross-sectional studies, however, the evidence from prospective studies has been limited. We conducted a systematic review and dose-response meta-analysis of different adiposity measures and the risk of psoriasis to provide a more robust summary of the evidence based on data from prospective studies. PubMed and Embase databases were searched for relevant studies up to August 8th 2017. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random effects model. The summary relative risk (RR) for a 5 unit increment in BMI was 1.19 (95% CI 1.10-1.28, I2 = 83%, n = 7). The association appeared to be stronger at higher compared to lower levels of BMI, pnonlinearity < 0.0001, and the lowest risk was observed at a BMI around 20. The summary RR was 1.24 (95% CI 1.17-1.31, I2 = 0%, pheterogeneity = 0.72, n = 3) per 10 cm increase in waist circumference, 1.37 (95% CI 1.23-1.53, I2 = 0%, pheterogeneity = 0.93, n = 3) per 0.1 unit increase in waist-to-hip ratio, and 1.11 (95% CI 1.07-1.16, I2 = 47%, pheterogeneity = 0.15, n = 3) per 5 kg of weight gain. Adiposity as measured by BMI, waist circumference, waist-to-hip ratio, and weight gain is associated with increased risk of psoriasis. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/29680995/Body_mass_index_abdominal_fatness_weight_gain_and_the_risk_of_psoriasis:_a_systematic_review_and_dose_response_meta_analysis_of_prospective_studies_ L2 - https://doi.org/10.1007/s10654-018-0366-z DB - PRIME DP - Unbound Medicine ER -