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Nocebo Effects: Neurobiological Mechanisms and Strategies for Prevention and Optimizing Treatment.
Int Rev Neurobiol. 2018; 138:271-283.IR

Abstract

Psychosocial and contextual factors, such as patient-physician relationship, prior treatment experience, and treatment expectation, can either improve or compromise treatment efficacy. These phenomena are commonly specified as placebo and nocebo effects. As placebo and nocebo effects can influence symptom development, adverse event rate, and treatment efficacy, it is crucial to be aware of these effects and to develop strategies for prevention to optimize treatment outcomes. While experimental studies have made substantial progress in elucidating the psychosocial and neurobiological mechanisms underlying placebo effects, the detailed mechanisms of nocebo effects remain largely unexplored. A better understanding of these mechanisms promises to facilitate the development of easy-to-use strategies in clinical care to improve overall treatment outcomes and patient satisfaction.

Authors+Show Affiliations

University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: julian.kleine-borgmann@uk-essen.de.University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29681330

Citation

Kleine-Borgmann, Julian, and Ulrike Bingel. "Nocebo Effects: Neurobiological Mechanisms and Strategies for Prevention and Optimizing Treatment." International Review of Neurobiology, vol. 138, 2018, pp. 271-283.
Kleine-Borgmann J, Bingel U. Nocebo Effects: Neurobiological Mechanisms and Strategies for Prevention and Optimizing Treatment. Int Rev Neurobiol. 2018;138:271-283.
Kleine-Borgmann, J., & Bingel, U. (2018). Nocebo Effects: Neurobiological Mechanisms and Strategies for Prevention and Optimizing Treatment. International Review of Neurobiology, 138, 271-283. https://doi.org/10.1016/bs.irn.2018.02.005
Kleine-Borgmann J, Bingel U. Nocebo Effects: Neurobiological Mechanisms and Strategies for Prevention and Optimizing Treatment. Int Rev Neurobiol. 2018;138:271-283. PubMed PMID: 29681330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nocebo Effects: Neurobiological Mechanisms and Strategies for Prevention and Optimizing Treatment. AU - Kleine-Borgmann,Julian, AU - Bingel,Ulrike, Y1 - 2018/04/02/ PY - 2018/4/24/entrez PY - 2018/4/24/pubmed PY - 2018/12/21/medline KW - Conditioning KW - Expectancy KW - Learning KW - Nocebo effect KW - Pain KW - Patient–physician relationship KW - Placebo effect KW - Treatment efficacy KW - Treatment optimization SP - 271 EP - 283 JF - International review of neurobiology JO - Int. Rev. Neurobiol. VL - 138 N2 - Psychosocial and contextual factors, such as patient-physician relationship, prior treatment experience, and treatment expectation, can either improve or compromise treatment efficacy. These phenomena are commonly specified as placebo and nocebo effects. As placebo and nocebo effects can influence symptom development, adverse event rate, and treatment efficacy, it is crucial to be aware of these effects and to develop strategies for prevention to optimize treatment outcomes. While experimental studies have made substantial progress in elucidating the psychosocial and neurobiological mechanisms underlying placebo effects, the detailed mechanisms of nocebo effects remain largely unexplored. A better understanding of these mechanisms promises to facilitate the development of easy-to-use strategies in clinical care to improve overall treatment outcomes and patient satisfaction. SN - 2162-5514 UR - https://www.unboundmedicine.com/medline/citation/29681330/Nocebo_Effects:_Neurobiological_Mechanisms_and_Strategies_for_Prevention_and_Optimizing_Treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0074-7742(18)30018-7 DB - PRIME DP - Unbound Medicine ER -