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Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM.
Comput Math Methods Med 2018; 2018:9425375CM

Abstract

The immersed boundary-lattice Boltzmann method (IB-LBM) was used to examine the motion and deformation of three elastic red blood cells (RBCs) during Poiseuille flow through constricted microchannels. The objective was to determine the effects of the degree of constriction and the Reynolds (Re) number of the flow on the physical characteristics of the RBCs. It was found that, with decreasing constriction ratio, the RBCs experienced greater forced deformation as they squeezed through the constriction area compared to at other parts of the microchannel. It was also observed that a longer time was required for the RBCs to squeeze through a narrower constriction. The RBCs subsequently regained a stable shape and gradually migrated toward the centerline of the flow beyond the constriction area. However, a sick RBC was observed to be incapable of passing through a constricted vessel with a constriction ratio ≤1/3 for Re numbers below 0.40.

Authors+Show Affiliations

Faculty of Mechanical Engineering and Automation, Zhejiang Sci-Tech University, Hangzhou 310018, China. College of Mechanical and Electrical Engineering, Huzhou Vocational and Technical College, Huzhou 313000, China.Faculty of Mechanical Engineering and Automation, Zhejiang Sci-Tech University, Hangzhou 310018, China.Faculty of Mechanical Engineering and Automation, Zhejiang Sci-Tech University, Hangzhou 310018, China.Faculty of Mechanical Engineering and Automation, Zhejiang Sci-Tech University, Hangzhou 310018, China.Faculty of Mechanical Engineering and Automation, Zhejiang Sci-Tech University, Hangzhou 310018, China. School of Mechanical Engineering and Automation, University of Science and Technology Liaoning, Anshan 114051, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29681999

Citation

Wang, Rongyang, et al. "Numerical Simulations of the Motion and Deformation of Three RBCs During Poiseuille Flow Through a Constricted Vessel Using IB-LBM." Computational and Mathematical Methods in Medicine, vol. 2018, 2018, p. 9425375.
Wang R, Wei Y, Wu C, et al. Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM. Comput Math Methods Med. 2018;2018:9425375.
Wang, R., Wei, Y., Wu, C., Sun, L., & Zheng, W. (2018). Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM. Computational and Mathematical Methods in Medicine, 2018, p. 9425375. doi:10.1155/2018/9425375.
Wang R, et al. Numerical Simulations of the Motion and Deformation of Three RBCs During Poiseuille Flow Through a Constricted Vessel Using IB-LBM. Comput Math Methods Med. 2018;2018:9425375. PubMed PMID: 29681999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Numerical Simulations of the Motion and Deformation of Three RBCs during Poiseuille Flow through a Constricted Vessel Using IB-LBM. AU - Wang,Rongyang, AU - Wei,Yikun, AU - Wu,Chuanyu, AU - Sun,Liang, AU - Zheng,Wenguang, Y1 - 2018/02/21/ PY - 2017/11/15/received PY - 2018/01/19/revised PY - 2018/01/23/accepted PY - 2018/4/24/entrez PY - 2018/4/24/pubmed PY - 2018/10/3/medline SP - 9425375 EP - 9425375 JF - Computational and mathematical methods in medicine JO - Comput Math Methods Med VL - 2018 N2 - The immersed boundary-lattice Boltzmann method (IB-LBM) was used to examine the motion and deformation of three elastic red blood cells (RBCs) during Poiseuille flow through constricted microchannels. The objective was to determine the effects of the degree of constriction and the Reynolds (Re) number of the flow on the physical characteristics of the RBCs. It was found that, with decreasing constriction ratio, the RBCs experienced greater forced deformation as they squeezed through the constriction area compared to at other parts of the microchannel. It was also observed that a longer time was required for the RBCs to squeeze through a narrower constriction. The RBCs subsequently regained a stable shape and gradually migrated toward the centerline of the flow beyond the constriction area. However, a sick RBC was observed to be incapable of passing through a constricted vessel with a constriction ratio ≤1/3 for Re numbers below 0.40. SN - 1748-6718 UR - https://www.unboundmedicine.com/medline/citation/29681999/Numerical_Simulations_of_the_Motion_and_Deformation_of_Three_RBCs_during_Poiseuille_Flow_through_a_Constricted_Vessel_Using_IB_LBM_ L2 - https://dx.doi.org/10.1155/2018/9425375 DB - PRIME DP - Unbound Medicine ER -