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Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats.
Phytother Res. 2018 Aug; 32(8):1574-1582.PR

Abstract

Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic complications. This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. Diabetic rats were divided into 3 groups treated orally with Sar (0, 20, or 60 mg/kg) and carboxymethylcellulose sodium, whereas normal rats for Sar (0 or 60 mg/kg) and carboxymethylcellulose sodium. We found that chronic treatment with Sar for 9 weeks significantly ameliorated renal dysfunction of diabetic rats, as evidenced by decreases in albuminuria, kidney weight index, serum uric acid, and morphologic changes such as extracellular matrix expansion and accumulation (fibronectin and collagen IV levels, etc.). Meanwhile, Sar treatment resulted in decreases in interleukin-18, NLRP3, and activated caspase 1 levels as well as advanced glycation endproducts (AGEs) and their receptor (RAGE) levels in the renal cortex of diabetic rats. However, Sar has no effects on the above indices in the normal rats. Therefore, Sar can markedly ameliorate diabetic nephropathy in rats via inhibition of NLRP3 inflammasome activation and AGEs-RAGE interaction.

Authors+Show Affiliations

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. Department of Pharmacology, School of Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.College of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29682805

Citation

Liu, Yao-Wu, et al. "Protective Effects of Sarsasapogenin Against Early Stage of Diabetic Nephropathy in Rats." Phytotherapy Research : PTR, vol. 32, no. 8, 2018, pp. 1574-1582.
Liu YW, Hao YC, Chen YJ, et al. Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats. Phytother Res. 2018;32(8):1574-1582.
Liu, Y. W., Hao, Y. C., Chen, Y. J., Yin, S. Y., Zhang, M. Y., Kong, L., & Wang, T. Y. (2018). Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats. Phytotherapy Research : PTR, 32(8), 1574-1582. https://doi.org/10.1002/ptr.6088
Liu YW, et al. Protective Effects of Sarsasapogenin Against Early Stage of Diabetic Nephropathy in Rats. Phytother Res. 2018;32(8):1574-1582. PubMed PMID: 29682805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats. AU - Liu,Yao-Wu, AU - Hao,Yun-Chao, AU - Chen,Ya-Jing, AU - Yin,Shen-Yuan, AU - Zhang,Meng-Ya, AU - Kong,Li, AU - Wang,Tao-Yun, Y1 - 2018/04/23/ PY - 2017/11/15/received PY - 2018/01/11/revised PY - 2018/03/14/accepted PY - 2018/4/24/pubmed PY - 2018/10/18/medline PY - 2018/4/24/entrez KW - AGEs/RAGE axis KW - NLRP3 inflammasome KW - diabetic nephropathy KW - sarsasapogenin KW - serum uric acid SP - 1574 EP - 1582 JF - Phytotherapy research : PTR JO - Phytother Res VL - 32 IS - 8 N2 - Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic complications. This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. Diabetic rats were divided into 3 groups treated orally with Sar (0, 20, or 60 mg/kg) and carboxymethylcellulose sodium, whereas normal rats for Sar (0 or 60 mg/kg) and carboxymethylcellulose sodium. We found that chronic treatment with Sar for 9 weeks significantly ameliorated renal dysfunction of diabetic rats, as evidenced by decreases in albuminuria, kidney weight index, serum uric acid, and morphologic changes such as extracellular matrix expansion and accumulation (fibronectin and collagen IV levels, etc.). Meanwhile, Sar treatment resulted in decreases in interleukin-18, NLRP3, and activated caspase 1 levels as well as advanced glycation endproducts (AGEs) and their receptor (RAGE) levels in the renal cortex of diabetic rats. However, Sar has no effects on the above indices in the normal rats. Therefore, Sar can markedly ameliorate diabetic nephropathy in rats via inhibition of NLRP3 inflammasome activation and AGEs-RAGE interaction. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/29682805/Protective_effects_of_sarsasapogenin_against_early_stage_of_diabetic_nephropathy_in_rats_ L2 - https://doi.org/10.1002/ptr.6088 DB - PRIME DP - Unbound Medicine ER -