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Impact of functionalized particle structure on roll compaction/dry granulation and tableting of calcium carbonate.
Int J Pharm. 2018 Jun 10; 544(1):235-241.IJ

Abstract

The influence of a functionalized raw material particle structure on the granulation behavior and tabletabilty of calcium carbonate (CaCO3) was investigated. Therefore, a milled grade of CaCO3 was compared to different binary mixtures of milled and functionalized CaCO3. Relevant properties of raw materials, ribbons and granules were measured. The starting materials and two fractions of dry granules were compressed to tablets. The tabletability of granules was compared to that of the powders and the influence of specific compaction force and granule size on tablet tensile strength was evaluated. Adding functionalized particles drastically influenced the granulation and tableting behavior of CaCO3. Increasing proportions increased the ribbon porosity and granule size. Tensile strength of tablets from powder mixtures and granules was increased as well. Nevertheless, adding functionalized CaCO3 led to a loss in tabletability induced by a previous compaction step to an extent depending on its proportion in the formulation. A clear influence of the particle morphology on granulation and tableting behavior was demonstrated by the study. The functionalized structure showed aspects of a more plastic deformation behavior. Adding functionalized CaCO3 to a mixture, even in small amounts, seemed to be beneficial to increase granule size and tablet strength.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Grote S
Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitaetstrasse1, 40225 Duesseldorf, Germany.
Kleinebudde P
Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitaetstrasse1, 40225 Duesseldorf, Germany. Electronic address: Kleinebudde@hhu.de.

MeSH

Calcium CarbonateExcipientsParticle SizePorosityPowdersTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29689365

Citation

Grote, Simon, and Peter Kleinebudde. "Impact of Functionalized Particle Structure On Roll Compaction/dry Granulation and Tableting of Calcium Carbonate." International Journal of Pharmaceutics, vol. 544, no. 1, 2018, pp. 235-241.
Grote S, Kleinebudde P. Impact of functionalized particle structure on roll compaction/dry granulation and tableting of calcium carbonate. Int J Pharm. 2018;544(1):235-241.
Grote, S., & Kleinebudde, P. (2018). Impact of functionalized particle structure on roll compaction/dry granulation and tableting of calcium carbonate. International Journal of Pharmaceutics, 544(1), 235-241. https://doi.org/10.1016/j.ijpharm.2018.04.044
Grote S, Kleinebudde P. Impact of Functionalized Particle Structure On Roll Compaction/dry Granulation and Tableting of Calcium Carbonate. Int J Pharm. 2018 Jun 10;544(1):235-241. PubMed PMID: 29689365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of functionalized particle structure on roll compaction/dry granulation and tableting of calcium carbonate. AU - Grote,Simon, AU - Kleinebudde,Peter, Y1 - 2018/04/22/ PY - 2018/02/28/received PY - 2018/04/10/revised PY - 2018/04/20/accepted PY - 2018/4/25/pubmed PY - 2018/9/27/medline PY - 2018/4/25/entrez KW - Compaction KW - Compression KW - Excipients KW - Particle morphology KW - Powder technology KW - Roll compaction/dry granulation SP - 235 EP - 241 JF - International journal of pharmaceutics JO - Int J Pharm VL - 544 IS - 1 N2 - The influence of a functionalized raw material particle structure on the granulation behavior and tabletabilty of calcium carbonate (CaCO3) was investigated. Therefore, a milled grade of CaCO3 was compared to different binary mixtures of milled and functionalized CaCO3. Relevant properties of raw materials, ribbons and granules were measured. The starting materials and two fractions of dry granules were compressed to tablets. The tabletability of granules was compared to that of the powders and the influence of specific compaction force and granule size on tablet tensile strength was evaluated. Adding functionalized particles drastically influenced the granulation and tableting behavior of CaCO3. Increasing proportions increased the ribbon porosity and granule size. Tensile strength of tablets from powder mixtures and granules was increased as well. Nevertheless, adding functionalized CaCO3 led to a loss in tabletability induced by a previous compaction step to an extent depending on its proportion in the formulation. A clear influence of the particle morphology on granulation and tableting behavior was demonstrated by the study. The functionalized structure showed aspects of a more plastic deformation behavior. Adding functionalized CaCO3 to a mixture, even in small amounts, seemed to be beneficial to increase granule size and tablet strength. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/29689365/Impact_of_functionalized_particle_structure_on_roll_compaction/dry_granulation_and_tableting_of_calcium_carbonate_ DB - PRIME DP - Unbound Medicine ER -