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Five-year incidence and progression of myopic maculopathy in a rural Chinese adult population: the Handan Eye Study.
Ophthalmic Physiol Opt. 2018 05; 38(3):337-345.OP

Abstract

PURPOSE

To determine the cumulative five-year incidence and progression of myopic maculopathy in a rural Chinese adult population.

METHODS

The Handan Eye Study was a population-based longitudinal study. In 2006, 6830 subjects aged 30+ years participated in this study (baseline). Five years later, 5394 subjects (follow-up rate: 85.3%) took part in the follow-up study. Participants had a detailed eye examination, including visual acuity, standardized refraction and fundus photography according to a similar protocol at both baseline and follow-up. Myopic maculopathy was defined as any of the following signs: diffuse chorioretinal atrophy, patchy chorioretinal atrophy, macular atrophy, lacquer cracks and myopic choroidal neovascularization at the posterior pole. Parapapillary atrophy was assessed separately.

RESULTS

Of 5394 participants, 5078 (10 021 eyes) had gradable fundus photographs. Over the five years, four participants (five eyes) developed new myopic maculopathy, with an eye-specific incidence of 0.05% (95% CI, 0.02-0.10%). Among the 51 eyes with myopic maculopathy at baseline, the progression occurred in 18 eyes (35.3%), with new signs of patchy chorioretinal atrophy in 11 eyes (21.6%), diffuse chorioretinal atrophy in seven eyes (13.7%), lacquer cracks in three eyes (6.9%), macular atrophy in three eyes (6.9%) and myopic choroidal neovascularization in two eyes (3.9%). By multivariable analysis, female gender (OR, 9.14; p = 0.004) and higher educational level (OR, 8.24; p = 0.004) were associated with a higher risk of progression of myopic maculopathy, whereas lower myopia at baseline (OR, 0.79; p < 0.0001) and hypertension (OR, 0.21; p = 0.017) were associated with a reduced risk.

CONCLUSIONS

The five-year incidence of myopic maculopathy was 0.05% in rural Chinese adults aged 30+ years. The progression rate in participants with myopic maculopathy was 35.3%, indicating the importance of regular follow-up for these patients.

Authors+Show Affiliations

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Handan Eye Hospital, Hebei Province, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29691931

Citation

Lin, Caixia, et al. "Five-year Incidence and Progression of Myopic Maculopathy in a Rural Chinese Adult Population: the Handan Eye Study." Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists), vol. 38, no. 3, 2018, pp. 337-345.
Lin C, Li SM, Ohno-Matsui K, et al. Five-year incidence and progression of myopic maculopathy in a rural Chinese adult population: the Handan Eye Study. Ophthalmic Physiol Opt. 2018;38(3):337-345.
Lin, C., Li, S. M., Ohno-Matsui, K., Wang, B. S., Fang, Y. X., Cao, K., Gao, L. Q., Hao, J., Zhang, Y., Wu, J., & Wang, N. L. (2018). Five-year incidence and progression of myopic maculopathy in a rural Chinese adult population: the Handan Eye Study. Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists), 38(3), 337-345. https://doi.org/10.1111/opo.12456
Lin C, et al. Five-year Incidence and Progression of Myopic Maculopathy in a Rural Chinese Adult Population: the Handan Eye Study. Ophthalmic Physiol Opt. 2018;38(3):337-345. PubMed PMID: 29691931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year incidence and progression of myopic maculopathy in a rural Chinese adult population: the Handan Eye Study. AU - Lin,Caixia, AU - Li,Shi-Ming, AU - Ohno-Matsui,Kyoko, AU - Wang,Bing Song, AU - Fang,Yu Xin, AU - Cao,Kai, AU - Gao,Li Qin, AU - Hao,Jie, AU - Zhang,Ye, AU - Wu,Jian, AU - Wang,Ning Li, AU - ,, PY - 2018/01/06/received PY - 2018/03/19/accepted PY - 2018/4/26/entrez PY - 2018/4/25/pubmed PY - 2019/3/5/medline KW - China KW - epidemiology KW - maculopathy KW - myopia SP - 337 EP - 345 JF - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JO - Ophthalmic Physiol Opt VL - 38 IS - 3 N2 - PURPOSE: To determine the cumulative five-year incidence and progression of myopic maculopathy in a rural Chinese adult population. METHODS: The Handan Eye Study was a population-based longitudinal study. In 2006, 6830 subjects aged 30+ years participated in this study (baseline). Five years later, 5394 subjects (follow-up rate: 85.3%) took part in the follow-up study. Participants had a detailed eye examination, including visual acuity, standardized refraction and fundus photography according to a similar protocol at both baseline and follow-up. Myopic maculopathy was defined as any of the following signs: diffuse chorioretinal atrophy, patchy chorioretinal atrophy, macular atrophy, lacquer cracks and myopic choroidal neovascularization at the posterior pole. Parapapillary atrophy was assessed separately. RESULTS: Of 5394 participants, 5078 (10 021 eyes) had gradable fundus photographs. Over the five years, four participants (five eyes) developed new myopic maculopathy, with an eye-specific incidence of 0.05% (95% CI, 0.02-0.10%). Among the 51 eyes with myopic maculopathy at baseline, the progression occurred in 18 eyes (35.3%), with new signs of patchy chorioretinal atrophy in 11 eyes (21.6%), diffuse chorioretinal atrophy in seven eyes (13.7%), lacquer cracks in three eyes (6.9%), macular atrophy in three eyes (6.9%) and myopic choroidal neovascularization in two eyes (3.9%). By multivariable analysis, female gender (OR, 9.14; p = 0.004) and higher educational level (OR, 8.24; p = 0.004) were associated with a higher risk of progression of myopic maculopathy, whereas lower myopia at baseline (OR, 0.79; p < 0.0001) and hypertension (OR, 0.21; p = 0.017) were associated with a reduced risk. CONCLUSIONS: The five-year incidence of myopic maculopathy was 0.05% in rural Chinese adults aged 30+ years. The progression rate in participants with myopic maculopathy was 35.3%, indicating the importance of regular follow-up for these patients. SN - 1475-1313 UR - https://www.unboundmedicine.com/medline/citation/29691931/Five_year_incidence_and_progression_of_myopic_maculopathy_in_a_rural_Chinese_adult_population:_the_Handan_Eye_Study_ L2 - https://doi.org/10.1111/opo.12456 DB - PRIME DP - Unbound Medicine ER -