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Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species.
Molecules 2018; 23(5)M

Abstract

Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL−1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL−1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL−1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL−1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants.

Authors+Show Affiliations

Department of Biological Sciences, Faculty of Sciences and Letters, University of São Paulo State (UNESP), Assis 19806-900, Brazil. csantos@assis.unesp.br.ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas 13083-970, Brazil. renann_galaverna@hotmail.com.ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas 13083-970, Brazil. celio.fernando@gmail.com.Department of Biological Sciences, Faculty of Sciences and Letters, University of São Paulo State (UNESP), Assis 19806-900, Brazil. vaninha.nunes@gmail.com.Department of Botany, Institute of Biosciences of Botucatu, UNESP-Univ. Estadual Paulista, Botucatu 18618-970, Brazil. luizfernando@ibb.unesp.br.Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP) P.O. Box 859, Campinas 13083-859, Brazil. ana.ruiz@fcf.unicamp.br.Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP) P.O. Box 859, Campinas 13083-859, Brazil. carvalho@fcf.unicamp.fcf.CPQBA, Microbiology Division, P.O. Box 6171, University of Campinas, Campinas 13083-970, Brazil. renataduarte@uol.com.br.CPQBA, Microbiology Division, P.O. Box 6171, University of Campinas, Campinas 13083-970, Brazil. mduarte@cpqba.unicamp.br.ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas 13083-970, Brazil. mneberlin@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29695037

Citation

Dos Santos, Catarina, et al. "Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds From Three Myrcia Species." Molecules (Basel, Switzerland), vol. 23, no. 5, 2018.
Dos Santos C, Galaverna RS, Angolini CFF, et al. Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species. Molecules. 2018;23(5).
Dos Santos, C., Galaverna, R. S., Angolini, C. F. F., Nunes, V. V. A., de Almeida, L. F. R., Ruiz, A. L. T. G., ... Eberlin, M. N. (2018). Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species. Molecules (Basel, Switzerland), 23(5), doi:10.3390/molecules23050986.
Dos Santos C, et al. Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds From Three Myrcia Species. Molecules. 2018 04 24;23(5) PubMed PMID: 29695037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species. AU - Dos Santos,Catarina, AU - Galaverna,Renan S, AU - Angolini,Celio F F, AU - Nunes,Vania V A, AU - de Almeida,Luiz F R, AU - Ruiz,Ana L T G, AU - de Carvalho,João E, AU - Duarte,Regina M T, AU - Duarte,Marta C T, AU - Eberlin,Marcos N, Y1 - 2018/04/24/ PY - 2018/02/21/received PY - 2018/03/24/revised PY - 2018/03/29/accepted PY - 2018/4/27/entrez PY - 2018/4/27/pubmed PY - 2018/9/19/medline KW - ESI(−)Q-TOF-MS KW - Myrcia spp. KW - biological activities KW - phenolic compounds JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 5 N2 - Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL−1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL−1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL−1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL−1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29695037/Antioxidative_Antiproliferative_and_Antimicrobial_Activities_of_Phenolic_Compounds_from_Three_Myrcia_Species_ L2 - http://www.mdpi.com/resolver?pii=molecules23050986 DB - PRIME DP - Unbound Medicine ER -