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Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats.
Int J Mol Sci. 2018 Apr 24; 19(5)IJ

Authors+Show Affiliations

Research Group on Bioactive Natural Products, Department of Pharmacy, Federal University of Rio Grande do Norte, 59012-570 Natal, Brazil. edilanearaujo@hotmail.com.Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, Brazil. gerlaneguerra@hotmail.com.Faculty of Health Sciences of Trairi, Federal University of Rio Grande do Norte, 59200-000 Santa Cruz, Brazil. daline_araujo@yahoo.com.br.Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, Brazil. auriprinino@gmail.com.Research Group on Bioactive Natural Products, Department of Pharmacy, Federal University of Rio Grande do Norte, 59012-570 Natal, Brazil. fernandesjm@outlook.com.Department of Morphology, Histology and Basic Pathology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, Brazil. araujojr@cb.ufrn.br.Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, Brazil. vcs.biomed@gmail.com.Department of Morphology, Histology and Basic Pathology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970 Natal, Brazil. thaisbida2011@hotmail.com.Department of Pharmacy, Federal University of Rio Grande do Norte, 59012-570 Natal, Brazil. lean_sf@yahoo.com.br.Research Group on Bioactive Natural Products, Department of Pharmacy, Federal University of Rio Grande do Norte, 59012-570 Natal, Brazil. silvanazucolotto@ufrnnet.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29695040

Citation

de Araújo, Edilane Rodrigues Dantas, et al. "Gastroprotective and Antioxidant Activity of Kalanchoe Brasiliensis and Kalanchoe Pinnata Leaf Juices Against Indomethacin and Ethanol-Induced Gastric Lesions in Rats." International Journal of Molecular Sciences, vol. 19, no. 5, 2018.
de Araújo ERD, Guerra GCB, Araújo DFS, et al. Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats. Int J Mol Sci. 2018;19(5).
de Araújo, E. R. D., Guerra, G. C. B., Araújo, D. F. S., de Araújo, A. A., Fernandes, J. M., de Araújo Júnior, R. F., da Silva, V. C., de Carvalho, T. G., Ferreira, L. S., & Zucolotto, S. M. (2018). Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats. International Journal of Molecular Sciences, 19(5). https://doi.org/10.3390/ijms19051265
de Araújo ERD, et al. Gastroprotective and Antioxidant Activity of Kalanchoe Brasiliensis and Kalanchoe Pinnata Leaf Juices Against Indomethacin and Ethanol-Induced Gastric Lesions in Rats. Int J Mol Sci. 2018 Apr 24;19(5) PubMed PMID: 29695040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats. AU - de Araújo,Edilane Rodrigues Dantas, AU - Guerra,Gerlane Coelho Bernardo, AU - Araújo,Daline Fernandes de Souza, AU - de Araújo,Aurigena Antunes, AU - Fernandes,Júlia Morais, AU - de Araújo Júnior,Raimundo Fernandes, AU - da Silva,Valéria Costa, AU - de Carvalho,Thaís Gomes, AU - Ferreira,Leandro de Santis, AU - Zucolotto,Silvana Maria, Y1 - 2018/04/24/ PY - 2018/03/07/received PY - 2018/03/26/revised PY - 2018/03/29/accepted PY - 2018/4/27/entrez PY - 2018/4/27/pubmed PY - 2018/9/21/medline KW - Crassulaceae KW - coirama KW - flavonoids KW - peptic ulcers JF - International journal of molecular sciences JO - Int J Mol Sci VL - 19 IS - 5 N2 - Kalanchoe brasiliensis and Kalanchoe pinnata are used interchangeably in traditional medicine for treating peptic ulcers and inflammatory problems. In this context, this study aims to characterize the chemical constituents and evaluate the gastroprotective activity of the leaf juices of the two species in acute gastric lesions models. Thin Layer Chromatography (TLC) and Ultra High Performance Liquid Chromatography coupled to Mass Spectrometer (UHPLC-MS) were performed for chemical characterization. Wistar rats were pre-treated orally with leaf juices (125, 250 and 500 mg/kg) or ranitidine (50 mg/kg). The peaks observed in the chromatogram of K. brasiliensis showed similar mass spectra to flavonoid glycosides derived from patuletin and eupafolin, while K. pinnata showed mass spectra similar to compounds derived from quercetin, patuletin, eupafolin and kaempferol. K. brasiliensis at all doses and K. pinnata at doses of 250 mg/kg and 500 mg/kg significantly reduced the lesions in the ethanol induction model. In the indomethacin induction model, both species showed significant results at doses of 250 and 500 mg/kg. Also, the pre-treatment with leaf juices increased the antioxidant defense system, glutathione (GSH), whereas malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels were significantly decreased. Treatment with leaf juices led to the upregulation of zone occludes-1 (ZO-1) and the downregulation of inducible nitric oxide synthase (iNOS) and factor nuclear-κβ transcription (NF-κB-p65), while also showing a cytoprotective effect and maintaining mucus production. These findings show that the leaf juices of the two species showed gastroprotective effects on ethanol and gastric indomethacin injury which were a consequence of gastric inflammation suppression, antioxidant activity and the maintenance of cytoprotective defenses and mucosal structure architecture. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/29695040/Gastroprotective_and_Antioxidant_Activity_of_Kalanchoe_brasiliensis_and_Kalanchoe_pinnata_Leaf_Juices_against_Indomethacin_and_Ethanol_Induced_Gastric_Lesions_in_Rats_ L2 - https://www.mdpi.com/resolver?pii=ijms19051265 DB - PRIME DP - Unbound Medicine ER -