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Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study.
Benef Microbes. 2018 Jun 15; 9(4):563-572.BM

Abstract

The efficacy of the probiotic strain, Bacillus coagulans Unique IS2 in the treatment of Irritable Bowel Syndrome (IBS) was evaluated in children. A total of 141 children of either sex in the age group 4-12 years, diagnosed with IBS according to the Rome III criteria, participated in the double-blind randomised controlled trial. Children received either B. coagulans Unique IS2 chewable tablets or placebo once daily for eight weeks followed by a two week follow-up period. Reduction in pain intensity as well as other symptoms associated with Irritable Bowel Syndrome like abdominal discomfort, bloating, distension, sense of incomplete evacuation, straining at stool, urgency of bowel movement, passage of gas and mucus, and bowel habit satisfaction were assessed. B. coagulans Unique IS2 treated group showed a greater reduction in pain scores as evaluated by a weekly pain intensity scale. There was a significant reduction (P<0.0001) in pain intensity in the probiotic treated group (7.6±0.98) as compared to the placebo group (4.2±1.41) by the end of the treatment period (8 weeks). There was also a significant improvement in stool consistency as well as reduction in abdominal discomfort, bloating, staining, urgency, incomplete evacuation and passage of gas. Bowel habit satisfaction and global assessment of relief was also observed in the B. coagulans Unique IS2 treated group as compared to the placebo group. This study demonstrates the efficacy of B. coagulans Unique IS2 in reducing the symptoms of Irritable Bowel Syndrome in children in the age group of 4-12 years.

Authors+Show Affiliations

1 Centre for Research & Development, Unique Biotech Ltd., Plot No. 2, Phase-II, Alexandria Knowledge Park, Hyderabad, Telangana 500078, India.1 Centre for Research & Development, Unique Biotech Ltd., Plot No. 2, Phase-II, Alexandria Knowledge Park, Hyderabad, Telangana 500078, India.2 Integrity Healthcare Services, Kailas Business Park, Vikhroli, Mumbai 400079, India.3 Angel Child Care, S Mistry Road, Antop Hill, Mumbai 400037, India.4 Life Veda Treatment and Research Centre, Pandurang Budhkar Marg, Worli, Mumbai 400030, India.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29695183

Citation

Sudha, M Ratna, et al. "Efficacy of Bacillus Coagulans Unique IS2 in Treatment of Irritable Bowel Syndrome in Children: a Double Blind, Randomised Placebo Controlled Study." Beneficial Microbes, vol. 9, no. 4, 2018, pp. 563-572.
Sudha MR, Jayanthi N, Aasin M, et al. Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study. Benef Microbes. 2018;9(4):563-572.
Sudha, M. R., Jayanthi, N., Aasin, M., Dhanashri, R. D., & Anirudh, T. (2018). Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study. Beneficial Microbes, 9(4), 563-572. https://doi.org/10.3920/BM2017.0129
Sudha MR, et al. Efficacy of Bacillus Coagulans Unique IS2 in Treatment of Irritable Bowel Syndrome in Children: a Double Blind, Randomised Placebo Controlled Study. Benef Microbes. 2018 Jun 15;9(4):563-572. PubMed PMID: 29695183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study. AU - Sudha,M Ratna, AU - Jayanthi,N, AU - Aasin,M, AU - Dhanashri,R D, AU - Anirudh,T, Y1 - 2018/04/26/ PY - 2018/4/27/pubmed PY - 2019/4/19/medline PY - 2018/4/27/entrez KW - B. coagulans Unique IS2 KW - irritable bowel syndrome KW - probiotics SP - 563 EP - 572 JF - Beneficial microbes JO - Benef Microbes VL - 9 IS - 4 N2 - The efficacy of the probiotic strain, Bacillus coagulans Unique IS2 in the treatment of Irritable Bowel Syndrome (IBS) was evaluated in children. A total of 141 children of either sex in the age group 4-12 years, diagnosed with IBS according to the Rome III criteria, participated in the double-blind randomised controlled trial. Children received either B. coagulans Unique IS2 chewable tablets or placebo once daily for eight weeks followed by a two week follow-up period. Reduction in pain intensity as well as other symptoms associated with Irritable Bowel Syndrome like abdominal discomfort, bloating, distension, sense of incomplete evacuation, straining at stool, urgency of bowel movement, passage of gas and mucus, and bowel habit satisfaction were assessed. B. coagulans Unique IS2 treated group showed a greater reduction in pain scores as evaluated by a weekly pain intensity scale. There was a significant reduction (P<0.0001) in pain intensity in the probiotic treated group (7.6±0.98) as compared to the placebo group (4.2±1.41) by the end of the treatment period (8 weeks). There was also a significant improvement in stool consistency as well as reduction in abdominal discomfort, bloating, staining, urgency, incomplete evacuation and passage of gas. Bowel habit satisfaction and global assessment of relief was also observed in the B. coagulans Unique IS2 treated group as compared to the placebo group. This study demonstrates the efficacy of B. coagulans Unique IS2 in reducing the symptoms of Irritable Bowel Syndrome in children in the age group of 4-12 years. SN - 1876-2891 UR - https://www.unboundmedicine.com/medline/citation/29695183/Efficacy_of_Bacillus_coagulans_Unique_IS2_in_treatment_of_irritable_bowel_syndrome_in_children:_a_double_blind_randomised_placebo_controlled_study_ L2 - https://www.wageningenacademic.com/doi/10.3920/BM2017.0129?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -