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Longitudinal association between egg consumption and the risk of cardiovascular disease: interaction with type 2 diabetes mellitus.
Nutr Diabetes. 2018 04 25; 8(1):20.ND

Abstract

BACKGROUND/OBJECTIVES

It remains unclear if high egg consumption has beneficial or adverse effects on cardiometabolic health. The present study prospectively evaluated the longitudinal association between egg-consumption levels and incident cardiovascular disease (CVD) among Korean adults.

SUBJECTS/METHODS

We conducted a prospective cohort study of 9248 Korean adults aged 40-69 years without CVD or cancer at the baseline from the Korean Genome and Epidemiology Study, Ansung-Ansan cohort, South Korea. The egg intake of the participants was estimated using a validated semiquantitative food frequency questionnaire at the baseline and the second follow-up examination and categorized into quartiles. CVD cases were identified using biennial questionnaires and confirmed through repeated in-depth personal interviews. Hazard ratios (HR) and 95% confidence interval (CI) were analyzed using Cox proportional hazard regression.

RESULTS

During the average follow-up of 7.3 years, 570 cases of CVD were newly diagnosed. After adjusting for multiple confounding variables, egg-intake levels were not associated with CVD incidence (HR: 1.14, 95% CI: 0.87-1.49, P for trend: 0.7). However, the association was modified by type 2 diabetes mellitus (T2DM) status. Egg consumption was significantly associated with an increased risk for incident CVD among participants with T2DM; individuals with the highest egg intake (4.2 ± 0.04 eggs/week) had a 2.8 times higher incidence of CVD (HR: 2.81, 95% CI: 1.25-6.30, P for trend: 0.02) than those with the lowest egg intake (0.1 ± 0.02 eggs/week). However, no association was observed among individuals without T2DM (HR: 1.03, 95% CI: 0.77-1.38, P for trend: 0.8).

CONCLUSIONS

Higher egg consumption may increase the risk for CVD in Korean patients with T2DM. Our findings provide a basis for the development of an optimal dietary cholesterol intake guideline for the Korean population.

Authors+Show Affiliations

Department of Food and Nutrition, Yeungnam University, Gyeongsan, Republic of Korea.Department of Public Health Sciences, BK21PLUS Program in Embodiment: Health-Society Interaction, Graduate School, Korea University, Seoul, Republic of Korea.Department of Food Science and Nutrition, Dong-A University, Busan, Republic of Korea.Department of Food and Nutrition, Yeungnam University, Gyeongsan, Republic of Korea. kypark@ynu.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29695709

Citation

Jang, Jiyoung, et al. "Longitudinal Association Between Egg Consumption and the Risk of Cardiovascular Disease: Interaction With Type 2 Diabetes Mellitus." Nutrition & Diabetes, vol. 8, no. 1, 2018, p. 20.
Jang J, Shin MJ, Kim OY, et al. Longitudinal association between egg consumption and the risk of cardiovascular disease: interaction with type 2 diabetes mellitus. Nutr Diabetes. 2018;8(1):20.
Jang, J., Shin, M. J., Kim, O. Y., & Park, K. (2018). Longitudinal association between egg consumption and the risk of cardiovascular disease: interaction with type 2 diabetes mellitus. Nutrition & Diabetes, 8(1), 20. https://doi.org/10.1038/s41387-018-0033-1
Jang J, et al. Longitudinal Association Between Egg Consumption and the Risk of Cardiovascular Disease: Interaction With Type 2 Diabetes Mellitus. Nutr Diabetes. 2018 04 25;8(1):20. PubMed PMID: 29695709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal association between egg consumption and the risk of cardiovascular disease: interaction with type 2 diabetes mellitus. AU - Jang,Jiyoung, AU - Shin,Min-Jeong, AU - Kim,Oh Yoen, AU - Park,Kyong, Y1 - 2018/04/25/ PY - 2017/11/21/received PY - 2018/03/16/accepted PY - 2018/03/04/revised PY - 2018/4/27/entrez PY - 2018/4/27/pubmed PY - 2019/3/16/medline SP - 20 EP - 20 JF - Nutrition & diabetes JO - Nutr Diabetes VL - 8 IS - 1 N2 - BACKGROUND/OBJECTIVES: It remains unclear if high egg consumption has beneficial or adverse effects on cardiometabolic health. The present study prospectively evaluated the longitudinal association between egg-consumption levels and incident cardiovascular disease (CVD) among Korean adults. SUBJECTS/METHODS: We conducted a prospective cohort study of 9248 Korean adults aged 40-69 years without CVD or cancer at the baseline from the Korean Genome and Epidemiology Study, Ansung-Ansan cohort, South Korea. The egg intake of the participants was estimated using a validated semiquantitative food frequency questionnaire at the baseline and the second follow-up examination and categorized into quartiles. CVD cases were identified using biennial questionnaires and confirmed through repeated in-depth personal interviews. Hazard ratios (HR) and 95% confidence interval (CI) were analyzed using Cox proportional hazard regression. RESULTS: During the average follow-up of 7.3 years, 570 cases of CVD were newly diagnosed. After adjusting for multiple confounding variables, egg-intake levels were not associated with CVD incidence (HR: 1.14, 95% CI: 0.87-1.49, P for trend: 0.7). However, the association was modified by type 2 diabetes mellitus (T2DM) status. Egg consumption was significantly associated with an increased risk for incident CVD among participants with T2DM; individuals with the highest egg intake (4.2 ± 0.04 eggs/week) had a 2.8 times higher incidence of CVD (HR: 2.81, 95% CI: 1.25-6.30, P for trend: 0.02) than those with the lowest egg intake (0.1 ± 0.02 eggs/week). However, no association was observed among individuals without T2DM (HR: 1.03, 95% CI: 0.77-1.38, P for trend: 0.8). CONCLUSIONS: Higher egg consumption may increase the risk for CVD in Korean patients with T2DM. Our findings provide a basis for the development of an optimal dietary cholesterol intake guideline for the Korean population. SN - 2044-4052 UR - https://www.unboundmedicine.com/medline/citation/29695709/Longitudinal_association_between_egg_consumption_and_the_risk_of_cardiovascular_disease:_interaction_with_type_2_diabetes_mellitus_ L2 - https://doi.org/10.1038/s41387-018-0033-1 DB - PRIME DP - Unbound Medicine ER -