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Microbial cleavage of zearalenone.
Xenobiotica. 1988 Apr; 18(4):365-71.X

Abstract

1. Zearalenone, a fungal oestrogenic compound, was subjected to microbial transformation studies. Preliminary screening with 150 fungal species showed that Gliocladium roseum was capable of metabolizing zearalenone in 80-90% yields. 2. Large-scale fermentation with G. roseum produced a 1:1 mixture of 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1-undecen-6'-one and 1-(3,5-dihydroxyphenyl)-6'-hydroxy-1-undecen-10'-one. The compounds were isolated and purified at -20 degrees C, and identified using spectroscopic analysis and by comparison to products obtained from alkaline hydrolysis of zearalenone.

Authors+Show Affiliations

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Minnesota, Minneapolis 55455.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2969647

Citation

el-Sharkawy, S, and Y J. Abul-Hajj. "Microbial Cleavage of Zearalenone." Xenobiotica; the Fate of Foreign Compounds in Biological Systems, vol. 18, no. 4, 1988, pp. 365-71.
el-Sharkawy S, Abul-Hajj YJ. Microbial cleavage of zearalenone. Xenobiotica. 1988;18(4):365-71.
el-Sharkawy, S., & Abul-Hajj, Y. J. (1988). Microbial cleavage of zearalenone. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 18(4), 365-71.
el-Sharkawy S, Abul-Hajj YJ. Microbial Cleavage of Zearalenone. Xenobiotica. 1988;18(4):365-71. PubMed PMID: 2969647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial cleavage of zearalenone. AU - el-Sharkawy,S, AU - Abul-Hajj,Y J, PY - 1988/4/1/pubmed PY - 1988/4/1/medline PY - 1988/4/1/entrez SP - 365 EP - 71 JF - Xenobiotica; the fate of foreign compounds in biological systems JO - Xenobiotica VL - 18 IS - 4 N2 - 1. Zearalenone, a fungal oestrogenic compound, was subjected to microbial transformation studies. Preliminary screening with 150 fungal species showed that Gliocladium roseum was capable of metabolizing zearalenone in 80-90% yields. 2. Large-scale fermentation with G. roseum produced a 1:1 mixture of 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1-undecen-6'-one and 1-(3,5-dihydroxyphenyl)-6'-hydroxy-1-undecen-10'-one. The compounds were isolated and purified at -20 degrees C, and identified using spectroscopic analysis and by comparison to products obtained from alkaline hydrolysis of zearalenone. SN - 0049-8254 UR - https://www.unboundmedicine.com/medline/citation/2969647/Microbial_cleavage_of_zearalenone_ L2 - http://www.tandfonline.com/doi/full/10.3109/00498258809041672 DB - PRIME DP - Unbound Medicine ER -