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Dietary carbohydrates and fatty liver disease: de novo lipogenesis.
Curr Opin Clin Nutr Metab Care 2018; 21(4):277-282CO

Abstract

PURPOSE OF REVIEW

To review recent evidence for the role of dietary carbohydrate in de novo lipogenesis (DNL) and nonalcoholic fatty liver disease (NAFLD).

RECENT FINDINGS

A large body of evidence suggests that increased hepatic DNL is a significant pathway contributing to the development of NAFLD. Dietary carbohydrates, in particular, fructose, have been shown to stimulate DNL and increase liver fat, although it is debated whether this is due to excess energy or fructose per se. Recent dietary intervention studies conducted in energy balance show that high-fructose diets increase DNL and liver fat, whereas fructose restriction decreases DNL and liver fat.

SUMMARY

The association of high-carbohydrate and high-sugar diets with NAFLD may in part be explained by the effect of sugar on increasing hepatic DNL.

Authors+Show Affiliations

College of Osteopathic Medicine, Touro University California, Vallejo. Children's Hospital Oakland Research Institute, Oakland.College of Osteopathic Medicine, Touro University California, Vallejo. Department of Medicine, University of California, San Francisco. Division of Endocrinology, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.College of Osteopathic Medicine, Touro University California, Vallejo. Department of Medicine, University of California, San Francisco. Division of Endocrinology, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

29697539

Citation

Chiu, Sally, et al. "Dietary Carbohydrates and Fatty Liver Disease: De Novo Lipogenesis." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 21, no. 4, 2018, pp. 277-282.
Chiu S, Mulligan K, Schwarz JM. Dietary carbohydrates and fatty liver disease: de novo lipogenesis. Curr Opin Clin Nutr Metab Care. 2018;21(4):277-282.
Chiu, S., Mulligan, K., & Schwarz, J. M. (2018). Dietary carbohydrates and fatty liver disease: de novo lipogenesis. Current Opinion in Clinical Nutrition and Metabolic Care, 21(4), pp. 277-282. doi:10.1097/MCO.0000000000000469.
Chiu S, Mulligan K, Schwarz JM. Dietary Carbohydrates and Fatty Liver Disease: De Novo Lipogenesis. Curr Opin Clin Nutr Metab Care. 2018;21(4):277-282. PubMed PMID: 29697539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary carbohydrates and fatty liver disease: de novo lipogenesis. AU - Chiu,Sally, AU - Mulligan,Kathleen, AU - Schwarz,Jean-Marc, PY - 2018/4/27/pubmed PY - 2019/3/19/medline PY - 2018/4/27/entrez SP - 277 EP - 282 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 21 IS - 4 N2 - PURPOSE OF REVIEW: To review recent evidence for the role of dietary carbohydrate in de novo lipogenesis (DNL) and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS: A large body of evidence suggests that increased hepatic DNL is a significant pathway contributing to the development of NAFLD. Dietary carbohydrates, in particular, fructose, have been shown to stimulate DNL and increase liver fat, although it is debated whether this is due to excess energy or fructose per se. Recent dietary intervention studies conducted in energy balance show that high-fructose diets increase DNL and liver fat, whereas fructose restriction decreases DNL and liver fat. SUMMARY: The association of high-carbohydrate and high-sugar diets with NAFLD may in part be explained by the effect of sugar on increasing hepatic DNL. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/29697539/Dietary_carbohydrates_and_fatty_liver_disease:_de_novo_lipogenesis_ L2 - http://Insights.ovid.com/pubmed?pmid=29697539 DB - PRIME DP - Unbound Medicine ER -