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Microalbuminuria in insulin-dependent diabetes: prevalence and practical consequences.
J Diabet Complications 1987 Jul-Sep; 1(3):76-80JD

Abstract

Urinary albumin excretion in a representative sample of 679 patients with Type I (insulin-dependent) diabetes, 18 to 50 years of age, was investigated. Patients on antihypertensive therapy were excluded. Urinary albumin excretion was examined in one 24 hour urine sample using an ELISA technique. Twenty-three per cent of the patients had microalbuminuria, i.e., 30-300 mg albumin/24 h. The prevalence of microalbuminuria was independent of sex, age, insulin dose and diabetes duration. In the majority of those cases in which microalbuminuria was found during the first 10 years of diabetes, the concentrations were in the lower range, i.e., 30-50 mg/24 h. The prevalence of incipient nephropathy (urinary albumin excretion in a single urine sample of 51-300 mg/24 h) increased with diabetes duration. In patients with incipient nephropathy hemoglobin A1c tended to be, and blood pressure was, elevated compared with age, sex, and duration matched patients with normal urinary albumin excretion rates (p = 0.08 and p less than 0.001, respectively). Urinary albumin excretion and blood pressure were significantly correlated in the total group (n = 401, r = 0.2, p less than 0.001). On the basis of these findings practical guidelines for the handling of patients with microalbuminuria are proposed.

Authors+Show Affiliations

Steno Memorial Hospital, Gentofte, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2969909

Citation

Niazy, S, et al. "Microalbuminuria in Insulin-dependent Diabetes: Prevalence and Practical Consequences." The Journal of Diabetic Complications, vol. 1, no. 3, 1987, pp. 76-80.
Niazy S, Feldt-Rasmussen B, Deckert T. Microalbuminuria in insulin-dependent diabetes: prevalence and practical consequences. J Diabet Complications. 1987;1(3):76-80.
Niazy, S., Feldt-Rasmussen, B., & Deckert, T. (1987). Microalbuminuria in insulin-dependent diabetes: prevalence and practical consequences. The Journal of Diabetic Complications, 1(3), pp. 76-80.
Niazy S, Feldt-Rasmussen B, Deckert T. Microalbuminuria in Insulin-dependent Diabetes: Prevalence and Practical Consequences. J Diabet Complications. 1987;1(3):76-80. PubMed PMID: 2969909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microalbuminuria in insulin-dependent diabetes: prevalence and practical consequences. AU - Niazy,S, AU - Feldt-Rasmussen,B, AU - Deckert,T, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 76 EP - 80 JF - The Journal of diabetic complications JO - J Diabet Complications VL - 1 IS - 3 N2 - Urinary albumin excretion in a representative sample of 679 patients with Type I (insulin-dependent) diabetes, 18 to 50 years of age, was investigated. Patients on antihypertensive therapy were excluded. Urinary albumin excretion was examined in one 24 hour urine sample using an ELISA technique. Twenty-three per cent of the patients had microalbuminuria, i.e., 30-300 mg albumin/24 h. The prevalence of microalbuminuria was independent of sex, age, insulin dose and diabetes duration. In the majority of those cases in which microalbuminuria was found during the first 10 years of diabetes, the concentrations were in the lower range, i.e., 30-50 mg/24 h. The prevalence of incipient nephropathy (urinary albumin excretion in a single urine sample of 51-300 mg/24 h) increased with diabetes duration. In patients with incipient nephropathy hemoglobin A1c tended to be, and blood pressure was, elevated compared with age, sex, and duration matched patients with normal urinary albumin excretion rates (p = 0.08 and p less than 0.001, respectively). Urinary albumin excretion and blood pressure were significantly correlated in the total group (n = 401, r = 0.2, p less than 0.001). On the basis of these findings practical guidelines for the handling of patients with microalbuminuria are proposed. SN - 0891-6632 UR - https://www.unboundmedicine.com/medline/citation/2969909/Microalbuminuria_in_insulin_dependent_diabetes:_prevalence_and_practical_consequences_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -