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Metabolic control in newly kidney transplanted insulin-dependent diabetics: improvement by insulin pump treatment (CSII).
J Diabet Complications. 1987 Jul-Sep; 1(3):81-6.JD

Abstract

Management of glucose homeostasis in newly kidney transplanted insulin-dependent diabetic patients is difficult. To examine whether continuous subcutaneous insulin infusion (CSII) could reverse this problem, six consecutive kidney-transplanted Type I diabetic patients either proceeded with conventional insulin therapy (CIT) or were changed to CSII beginning on the third postoperative day. After a mean of 13 days, the insulin administration mode was changed from CIT to CSII (n = 3) or from CSII to CIT (n = 3), and continued for a further 15 days. Mean blood glucose calculated on the basis of four daily measurements (8.00, 12.00, 17.00, 22.00 h) during the study periods was significantly lower during CSII (8.0 +/- 0.4 mmol/l, mean +/- SEM) than on CIT (11.0 +/- 0.6 mmol/l; p less than 0.005). Moreover, the variability of blood glucose expressed as the M-value was lower during the pump treatment compared to CIT (p less than 0.001), while the number of blood glucose values below 3.0 mmol/l was similar (3.8 vs. 4.4%). Diurnal metabolic and hormonal profiles were twice determined on each regimen with 2 hourly sampling. Glycemic control was again found to be improved during CSII therapy as compared to CIT (p less than 0.01 or 0.05 less than p less than 0.10). Moreover, insulin pump treatment resulted in a significant reduction of two major intermediary metabolites, lactate and glycerol (p less than 0.05 and p less than 0.01, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Schmitz O
First University Clinic of Internal Medicine, Kommunehospitalet, Aarhus C, Denmark.
Sorensen SS
No affiliation info available
Alberti KG
No affiliation info available
Orskov H
No affiliation info available
Hansen HE
No affiliation info available

MeSH

Blood GlucoseClinical Trials as TopicDiabetes Mellitus, Type 1Diabetic NephropathiesGlucagonGrowth HormoneHomeostasisHumansInsulinInsulin Infusion SystemsKidney Transplantation

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2969910

Citation

Schmitz, O, et al. "Metabolic Control in Newly Kidney Transplanted Insulin-dependent Diabetics: Improvement By Insulin Pump Treatment (CSII)." The Journal of Diabetic Complications, vol. 1, no. 3, 1987, pp. 81-6.
Schmitz O, Sorensen SS, Alberti KG, et al. Metabolic control in newly kidney transplanted insulin-dependent diabetics: improvement by insulin pump treatment (CSII). J Diabet Complications. 1987;1(3):81-6.
Schmitz, O., Sorensen, S. S., Alberti, K. G., Orskov, H., & Hansen, H. E. (1987). Metabolic control in newly kidney transplanted insulin-dependent diabetics: improvement by insulin pump treatment (CSII). The Journal of Diabetic Complications, 1(3), 81-6.
Schmitz O, et al. Metabolic Control in Newly Kidney Transplanted Insulin-dependent Diabetics: Improvement By Insulin Pump Treatment (CSII). J Diabet Complications. 1987 Jul-Sep;1(3):81-6. PubMed PMID: 2969910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic control in newly kidney transplanted insulin-dependent diabetics: improvement by insulin pump treatment (CSII). AU - Schmitz,O, AU - Sorensen,S S, AU - Alberti,K G, AU - Orskov,H, AU - Hansen,H E, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 81 EP - 6 JF - The Journal of diabetic complications JO - J Diabet Complications VL - 1 IS - 3 N2 - Management of glucose homeostasis in newly kidney transplanted insulin-dependent diabetic patients is difficult. To examine whether continuous subcutaneous insulin infusion (CSII) could reverse this problem, six consecutive kidney-transplanted Type I diabetic patients either proceeded with conventional insulin therapy (CIT) or were changed to CSII beginning on the third postoperative day. After a mean of 13 days, the insulin administration mode was changed from CIT to CSII (n = 3) or from CSII to CIT (n = 3), and continued for a further 15 days. Mean blood glucose calculated on the basis of four daily measurements (8.00, 12.00, 17.00, 22.00 h) during the study periods was significantly lower during CSII (8.0 +/- 0.4 mmol/l, mean +/- SEM) than on CIT (11.0 +/- 0.6 mmol/l; p less than 0.005). Moreover, the variability of blood glucose expressed as the M-value was lower during the pump treatment compared to CIT (p less than 0.001), while the number of blood glucose values below 3.0 mmol/l was similar (3.8 vs. 4.4%). Diurnal metabolic and hormonal profiles were twice determined on each regimen with 2 hourly sampling. Glycemic control was again found to be improved during CSII therapy as compared to CIT (p less than 0.01 or 0.05 less than p less than 0.10). Moreover, insulin pump treatment resulted in a significant reduction of two major intermediary metabolites, lactate and glycerol (p less than 0.05 and p less than 0.01, respectively).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0891-6632 UR - https://www.unboundmedicine.com/medline/citation/2969910/Metabolic_control_in_newly_kidney_transplanted_insulin_dependent_diabetics:_improvement_by_insulin_pump_treatment__CSII__ DB - PRIME DP - Unbound Medicine ER -