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Intravenous leiomyomatosis of the uterus: A clinicopathologic analysis of 13 cases with an emphasis on histogenesis.
Pathol Res Pract. 2018 Jun; 214(6):871-875.PR

Abstract

The object of this study is to investigate the prognosis and potential histologic origin of uterine intravenous leiomyomatosis (IVL). We retrospectively analyzed the clinicopathologic and immunohistochemical features of 13 cases of IVL from a single institute. The patients underwent hysterectomy (3 with bilateral salpingo-oophorectomy, and 8 with excision of the broad ligaments and/or parametrium). They survived with no evidence of disease for 6-90 months. Intravascular worm-like plugs were macroscopically identified in the myometrium in 10 of 13 cases (76.9%). Six patients (46.1%) had extra-uterine involvement. Histopathologically, the intravascular tumor foci were covered with endothelium. We found the presence of congested vessels in the tumor and the surrounding myometrium in 9 of 13 cases (69.2%). The concurrent entities included seven uterine leiomyomas, one leiomyoma with adenomyosis, one adenomyosis, and one pulmonary benign metastasizing leiomyoma. Estrogen receptor and desmin were positive in IVL, and negative in the vascular wall. We conclude that IVL confined to the uterus may have a favorable prognosis, and we believe IVL is likely to originate from contiguous leiomyoma or myometrium.

Authors+Show Affiliations

Department of Surgical Pathology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang Province, 310002, PR China. Electronic address: 5516046@zju.edu.cn.Department of Surgical Pathology, The Affiliated Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang Province, 310002, PR China; Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, The Affiliated Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang Province, 310002, PR China. Electronic address: lbj@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29699902

Citation

Tang, Lanlan, and Bingjian Lu. "Intravenous Leiomyomatosis of the Uterus: a Clinicopathologic Analysis of 13 Cases With an Emphasis On Histogenesis." Pathology, Research and Practice, vol. 214, no. 6, 2018, pp. 871-875.
Tang L, Lu B. Intravenous leiomyomatosis of the uterus: A clinicopathologic analysis of 13 cases with an emphasis on histogenesis. Pathol Res Pract. 2018;214(6):871-875.
Tang, L., & Lu, B. (2018). Intravenous leiomyomatosis of the uterus: A clinicopathologic analysis of 13 cases with an emphasis on histogenesis. Pathology, Research and Practice, 214(6), 871-875. https://doi.org/10.1016/j.prp.2018.04.011
Tang L, Lu B. Intravenous Leiomyomatosis of the Uterus: a Clinicopathologic Analysis of 13 Cases With an Emphasis On Histogenesis. Pathol Res Pract. 2018;214(6):871-875. PubMed PMID: 29699902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous leiomyomatosis of the uterus: A clinicopathologic analysis of 13 cases with an emphasis on histogenesis. AU - Tang,Lanlan, AU - Lu,Bingjian, Y1 - 2018/04/22/ PY - 2018/01/19/received PY - 2018/04/03/revised PY - 2018/04/17/accepted PY - 2018/4/28/pubmed PY - 2018/10/3/medline PY - 2018/4/28/entrez KW - Histogenesis KW - Immunohistochemistry KW - Prognosis KW - Uterus KW - intravenous leiomyomatosis (IVL) SP - 871 EP - 875 JF - Pathology, research and practice JO - Pathol. Res. Pract. VL - 214 IS - 6 N2 - The object of this study is to investigate the prognosis and potential histologic origin of uterine intravenous leiomyomatosis (IVL). We retrospectively analyzed the clinicopathologic and immunohistochemical features of 13 cases of IVL from a single institute. The patients underwent hysterectomy (3 with bilateral salpingo-oophorectomy, and 8 with excision of the broad ligaments and/or parametrium). They survived with no evidence of disease for 6-90 months. Intravascular worm-like plugs were macroscopically identified in the myometrium in 10 of 13 cases (76.9%). Six patients (46.1%) had extra-uterine involvement. Histopathologically, the intravascular tumor foci were covered with endothelium. We found the presence of congested vessels in the tumor and the surrounding myometrium in 9 of 13 cases (69.2%). The concurrent entities included seven uterine leiomyomas, one leiomyoma with adenomyosis, one adenomyosis, and one pulmonary benign metastasizing leiomyoma. Estrogen receptor and desmin were positive in IVL, and negative in the vascular wall. We conclude that IVL confined to the uterus may have a favorable prognosis, and we believe IVL is likely to originate from contiguous leiomyoma or myometrium. SN - 1618-0631 UR - https://www.unboundmedicine.com/medline/citation/29699902/Intravenous_leiomyomatosis_of_the_uterus:_A_clinicopathologic_analysis_of_13_cases_with_an_emphasis_on_histogenesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(18)30068-2 DB - PRIME DP - Unbound Medicine ER -
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