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Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: A Meta-Analysis of Cohort Studies.
Curr Alzheimer Res. 2018; 15(9):869-876.CA

Abstract

BACKGROUND

Epidemiological studies showed that dietary fat intake is associated with Alzheimer's disease (AD) and dementia risk, however, the association remain inconsistent. This metaanalysis aimed to systematically examine the association of dietary fat intake with AD and dementia risk.

METHODS

We have systematically searched PubMed, Embase and the Cochrane Library up to May 1st 2017. Prospective cohort studies were included if they reported on the association of dietary fat intake with AD and dementia risk. Multivariate-adjusted relative risks (RRs) for the highest versus lowest category were pooled by using a random-effects model.

RESULTS

A total of 8630 participants and 633 cases from four independent prospective cohort studies were included in the present meta-analysis. A higher dietary saturated fat intake was significantly associated with an increased risk of 39% and 105% for AD (RR: 1.39; 95% CI: 1.00, 1.94) and dementia (RR: 2.05; 95% CI: 1.06, 3.98), respectively. Dose-response analysis indicated a 4 g/day increment of saturated fat intake was related to 15% higher risk of AD (RR: 1.15; 95% CI: 1.01, 1.31). However, there was no significant association found between dietary intake of total, monounsaturated, polyunsaturated fat and AD or dementia risk.

CONCLUSIONS

This meta-analysis provides significant evidence of positive association between higher saturated fat intake and AD and dementia risk.

Authors+Show Affiliations

Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.Institute of Nutrition and Health, Qingdao University, Qingdao, China.Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. Institute of Nutrition and Health, Qingdao University, Qingdao, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29701155

Citation

Ruan, Yue, et al. "Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: a Meta-Analysis of Cohort Studies." Current Alzheimer Research, vol. 15, no. 9, 2018, pp. 869-876.
Ruan Y, Tang J, Guo X, et al. Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: A Meta-Analysis of Cohort Studies. Curr Alzheimer Res. 2018;15(9):869-876.
Ruan, Y., Tang, J., Guo, X., Li, K., & Li, D. (2018). Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: A Meta-Analysis of Cohort Studies. Current Alzheimer Research, 15(9), 869-876. https://doi.org/10.2174/1567205015666180427142350
Ruan Y, et al. Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: a Meta-Analysis of Cohort Studies. Curr Alzheimer Res. 2018;15(9):869-876. PubMed PMID: 29701155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: A Meta-Analysis of Cohort Studies. AU - Ruan,Yue, AU - Tang,Jun, AU - Guo,Xiaofei, AU - Li,Kelei, AU - Li,Duo, PY - 2017/11/12/received PY - 2018/03/15/revised PY - 2018/04/25/accepted PY - 2018/4/28/pubmed PY - 2019/8/16/medline PY - 2018/4/28/entrez KW - Alzheimer's disease KW - cohort studies KW - dementia KW - dose-response KW - meta-analysis KW - saturated fat. SP - 869 EP - 876 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 15 IS - 9 N2 - BACKGROUND: Epidemiological studies showed that dietary fat intake is associated with Alzheimer's disease (AD) and dementia risk, however, the association remain inconsistent. This metaanalysis aimed to systematically examine the association of dietary fat intake with AD and dementia risk. METHODS: We have systematically searched PubMed, Embase and the Cochrane Library up to May 1st 2017. Prospective cohort studies were included if they reported on the association of dietary fat intake with AD and dementia risk. Multivariate-adjusted relative risks (RRs) for the highest versus lowest category were pooled by using a random-effects model. RESULTS: A total of 8630 participants and 633 cases from four independent prospective cohort studies were included in the present meta-analysis. A higher dietary saturated fat intake was significantly associated with an increased risk of 39% and 105% for AD (RR: 1.39; 95% CI: 1.00, 1.94) and dementia (RR: 2.05; 95% CI: 1.06, 3.98), respectively. Dose-response analysis indicated a 4 g/day increment of saturated fat intake was related to 15% higher risk of AD (RR: 1.15; 95% CI: 1.01, 1.31). However, there was no significant association found between dietary intake of total, monounsaturated, polyunsaturated fat and AD or dementia risk. CONCLUSIONS: This meta-analysis provides significant evidence of positive association between higher saturated fat intake and AD and dementia risk. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/29701155/Dietary_Fat_Intake_and_Risk_of_Alzheimer's_Disease_and_Dementia:_A_Meta_Analysis_of_Cohort_Studies_ DB - PRIME DP - Unbound Medicine ER -