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Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice.
Lipids Health Dis. 2018 Apr 27; 17(1):97.LH

Abstract

BACKGROUND

Increased intramuscular peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) with exercise directly or indirectly affects other tissues, but the effector pathway of PGC-1α has not been clearly elucidated. The purpose of this study was to investigate the effect of exercise and/or dietary change on the protein levels of the soleus muscle energy-sensing network and meteorin-like (Metrnl), and additionally to analyze the detraining and retraining effects in high-fat diet (HFD)-induced obese mice.

METHODS

One hundred male C57BL/6 mice were divided into normal-diet + sedentary (CO, n = 20) and HFD + sedentary (HF, n = 80) groups, and obesity was induced in the HF group through consumption of a 45% HFD for 6 weeks. The HF group was subdivided into HF only (n = 20), HF + training (HFT, n = 20), dietary change + sedentary (HFND, n = 20), and HFND + training (HFNDT, n = 20) groups, and the mice in the training groups underwent a treadmill training for 8 weeks, 5 times per week, 40 min per day. The HFT and HFNDT groups underwent 8-week training, 8-week detraining, and 4-week retraining.

RESULTS

An 8-week training was effective in increasing the protein levels of soleus muscle AMP-activated protein kinase (AMPK), PGC-1α, and plasma Metrnl in the obese mice (P < 0.05). Moreover, exercise in obesity reduced body weight (P < 0.05), and exercise with dietary conversion was effective in reducing body weight (P < 0.05) and fat mass (P < 0.05) after 8-week training. 8-week detraining restored the increased protein level to the pre-exercise state, but, the previous exercise effect in body weight and fat mass (P < 0.05) of the HFNDT group remained until the end of 4-week detraining. 4-week retraining was effective in increasing the protein levels of soleus muscle AMPK, PGC-1α, blood Metrnl (P < 0.05), and reducing in body weight (P < 0.05) and fat mass (P < 0.05), when retraining with dietary change.

CONCLUSIONS

The results of this study suggest that regular exercise is indispensable to reduce body weight and fat mass through upregulation of the muscle energy-sensing network and Metrnl protein levels, and retraining with dietary change is necessary to obtain the retraining effects more quickly.

Authors+Show Affiliations

Laboratory of Exercise Biochemistry, Department of Physical Education, College of Arts and Physical Education, Dong-A University, 37 Nakdong-daero 550 beon-gil, Hadan-dong, Saha-gu, Busan, 604-714, Republic of Korea.Laboratory of Exercise Biochemistry, Department of Physical Education, College of Arts and Physical Education, Dong-A University, 37 Nakdong-daero 550 beon-gil, Hadan-dong, Saha-gu, Busan, 604-714, Republic of Korea.Laboratory of Exercise Physiology, Division of Sport Science, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do, 24341, Republic of Korea.Laboratory of Exercise Biochemistry, Department of Physical Education, College of Arts and Physical Education, Dong-A University, 37 Nakdong-daero 550 beon-gil, Hadan-dong, Saha-gu, Busan, 604-714, Republic of Korea. kshin21@dau.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29703203

Citation

Bae, Ju Yong, et al. "Effects of Detraining and Retraining On Muscle Energy-sensing Network and Meteorin-like Levels in Obese Mice." Lipids in Health and Disease, vol. 17, no. 1, 2018, p. 97.
Bae JY, Woo J, Kang S, et al. Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice. Lipids Health Dis. 2018;17(1):97.
Bae, J. Y., Woo, J., Kang, S., & Shin, K. O. (2018). Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice. Lipids in Health and Disease, 17(1), 97. https://doi.org/10.1186/s12944-018-0751-3
Bae JY, et al. Effects of Detraining and Retraining On Muscle Energy-sensing Network and Meteorin-like Levels in Obese Mice. Lipids Health Dis. 2018 Apr 27;17(1):97. PubMed PMID: 29703203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice. AU - Bae,Ju Yong, AU - Woo,Jinhee, AU - Kang,Sunghwun, AU - Shin,Ki Ok, Y1 - 2018/04/27/ PY - 2017/08/29/received PY - 2018/04/19/accepted PY - 2018/4/29/entrez PY - 2018/4/29/pubmed PY - 2018/9/25/medline KW - AMPK KW - Detraining KW - Meteorin-like KW - PGC-1α KW - Retraining KW - SIRT-1 SP - 97 EP - 97 JF - Lipids in health and disease JO - Lipids Health Dis VL - 17 IS - 1 N2 - BACKGROUND: Increased intramuscular peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) with exercise directly or indirectly affects other tissues, but the effector pathway of PGC-1α has not been clearly elucidated. The purpose of this study was to investigate the effect of exercise and/or dietary change on the protein levels of the soleus muscle energy-sensing network and meteorin-like (Metrnl), and additionally to analyze the detraining and retraining effects in high-fat diet (HFD)-induced obese mice. METHODS: One hundred male C57BL/6 mice were divided into normal-diet + sedentary (CO, n = 20) and HFD + sedentary (HF, n = 80) groups, and obesity was induced in the HF group through consumption of a 45% HFD for 6 weeks. The HF group was subdivided into HF only (n = 20), HF + training (HFT, n = 20), dietary change + sedentary (HFND, n = 20), and HFND + training (HFNDT, n = 20) groups, and the mice in the training groups underwent a treadmill training for 8 weeks, 5 times per week, 40 min per day. The HFT and HFNDT groups underwent 8-week training, 8-week detraining, and 4-week retraining. RESULTS: An 8-week training was effective in increasing the protein levels of soleus muscle AMP-activated protein kinase (AMPK), PGC-1α, and plasma Metrnl in the obese mice (P < 0.05). Moreover, exercise in obesity reduced body weight (P < 0.05), and exercise with dietary conversion was effective in reducing body weight (P < 0.05) and fat mass (P < 0.05) after 8-week training. 8-week detraining restored the increased protein level to the pre-exercise state, but, the previous exercise effect in body weight and fat mass (P < 0.05) of the HFNDT group remained until the end of 4-week detraining. 4-week retraining was effective in increasing the protein levels of soleus muscle AMPK, PGC-1α, blood Metrnl (P < 0.05), and reducing in body weight (P < 0.05) and fat mass (P < 0.05), when retraining with dietary change. CONCLUSIONS: The results of this study suggest that regular exercise is indispensable to reduce body weight and fat mass through upregulation of the muscle energy-sensing network and Metrnl protein levels, and retraining with dietary change is necessary to obtain the retraining effects more quickly. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/29703203/Effects_of_detraining_and_retraining_on_muscle_energy_sensing_network_and_meteorin_like_levels_in_obese_mice_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0751-3 DB - PRIME DP - Unbound Medicine ER -