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Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats.
Neuropsychopharmacology. 2018 07; 43(8):1753-1762.N

Abstract

Amphetamine maintenance is effective clinically to reduce the consumption of the monoamine uptake inhibitor cocaine but not of the monoamine releaser methamphetamine, and its effectiveness in treating the abuse of other psychostimulants is not known. The mechanisms for differential amphetamine-maintenance effectiveness to treat different types of psychostimulant abuse are also not known. Accordingly, the present study compared the effects of amphetamine maintenance on abuse-related behavioral and neurochemical effects of cocaine, methamphetamine, and the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV) in rats. In behavioral studies, rats were trained to lever press for electrical brain stimulation in an intracranial self-stimulation (ICSS) procedure. In neurochemical studies, nucleus accumbens (NAc) levels of dopamine (DA) and serotonin (5-HT) were monitored by in vivo microdialysis. Cocaine, methamphetamine, and MDPV each produced dose-dependent ICSS facilitation and increases in NAc DA; cocaine and methamphetamine also increased NAc 5-HT. Amphetamine maintenance (0.32 mg/kg/h × 7 days) produced (1) sustained increases in basal ICSS and NAc DA with no change in NAc 5-HT, (2) blockade of cocaine but not methamphetamine effects on ICSS and NAc DA, and (3) no blockade of cocaine- or methamphetamine-induced increases in NAc 5-HT. Amphetamine maintenance blocked the increases in NAc DA produced by the selective DA uptake inhibitor MDPV, but it did not block MDPV-induced ICSS facilitation. These results show different effects of amphetamine maintenance on behavioral and neurochemical effects of different psychostimulants. The selective effectiveness of amphetamine maintenance to treat cocaine abuse may reflect attenuation of cocaine-induced increases in NAc DA while preserving cocaine-induced increases in NAc 5-HT.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA. sidney.negus@vcuhealth.org.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29703999

Citation

Johnson, Amy R., et al. "Amphetamine Maintenance Differentially Modulates Effects of Cocaine, Methylenedioxypyrovalerone (MDPV), and Methamphetamine On Intracranial Self-stimulation and Nucleus Accumbens Dopamine in Rats." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 43, no. 8, 2018, pp. 1753-1762.
Johnson AR, Banks ML, Selley DE, et al. Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology. 2018;43(8):1753-1762.
Johnson, A. R., Banks, M. L., Selley, D. E., & Negus, S. S. (2018). Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 43(8), 1753-1762. https://doi.org/10.1038/s41386-018-0071-3
Johnson AR, et al. Amphetamine Maintenance Differentially Modulates Effects of Cocaine, Methylenedioxypyrovalerone (MDPV), and Methamphetamine On Intracranial Self-stimulation and Nucleus Accumbens Dopamine in Rats. Neuropsychopharmacology. 2018;43(8):1753-1762. PubMed PMID: 29703999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. AU - Johnson,Amy R, AU - Banks,Matthew L, AU - Selley,Dana E, AU - Negus,S Stevens, Y1 - 2018/04/19/ PY - 2018/01/02/received PY - 2018/04/10/accepted PY - 2018/02/26/revised PY - 2018/4/29/pubmed PY - 2019/2/15/medline PY - 2018/4/29/entrez SP - 1753 EP - 1762 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 43 IS - 8 N2 - Amphetamine maintenance is effective clinically to reduce the consumption of the monoamine uptake inhibitor cocaine but not of the monoamine releaser methamphetamine, and its effectiveness in treating the abuse of other psychostimulants is not known. The mechanisms for differential amphetamine-maintenance effectiveness to treat different types of psychostimulant abuse are also not known. Accordingly, the present study compared the effects of amphetamine maintenance on abuse-related behavioral and neurochemical effects of cocaine, methamphetamine, and the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV) in rats. In behavioral studies, rats were trained to lever press for electrical brain stimulation in an intracranial self-stimulation (ICSS) procedure. In neurochemical studies, nucleus accumbens (NAc) levels of dopamine (DA) and serotonin (5-HT) were monitored by in vivo microdialysis. Cocaine, methamphetamine, and MDPV each produced dose-dependent ICSS facilitation and increases in NAc DA; cocaine and methamphetamine also increased NAc 5-HT. Amphetamine maintenance (0.32 mg/kg/h × 7 days) produced (1) sustained increases in basal ICSS and NAc DA with no change in NAc 5-HT, (2) blockade of cocaine but not methamphetamine effects on ICSS and NAc DA, and (3) no blockade of cocaine- or methamphetamine-induced increases in NAc 5-HT. Amphetamine maintenance blocked the increases in NAc DA produced by the selective DA uptake inhibitor MDPV, but it did not block MDPV-induced ICSS facilitation. These results show different effects of amphetamine maintenance on behavioral and neurochemical effects of different psychostimulants. The selective effectiveness of amphetamine maintenance to treat cocaine abuse may reflect attenuation of cocaine-induced increases in NAc DA while preserving cocaine-induced increases in NAc 5-HT. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/29703999/Amphetamine_maintenance_differentially_modulates_effects_of_cocaine_methylenedioxypyrovalerone__MDPV__and_methamphetamine_on_intracranial_self_stimulation_and_nucleus_accumbens_dopamine_in_rats_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29703999/ DB - PRIME DP - Unbound Medicine ER -