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Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis.
Biochem Biophys Res Commun 2018; 501(2):380-386BB

Abstract

Homeobox-containing 1 (HMBOX1) has been described as a transcription factor involved in the occurrence of some tumors, but its roles in ovarian cancer have never been reported. Here we aimed to investigate the roles of HMBOX1 on high-grade serous ovarian carcinoma (HGSOC). In this present study, HMBOX1 expression was decreased in HGSOC tissues and ovarian cancer cell lines (HO8910 and A2780) compared with ovarian surface epithelial tissues or normal human ovarian surface epithelial cell line (HOSEpiC). The cell proliferation of HOSEpiC was weaker than ovarian cancer cell lines. By altering the expression of HMBOX1 in A2780 and HOSEpiC, we demonstrated that HMBOX1 inhibited the cell proliferation and promoted the cell apoptosis. Furthermore, our study revealed that HMBOX1 downregulated the expression of anti-apoptotic proteins (Bcl-2, Bcl-xL), raised the expression of pro-apoptotic-regulated proteins (Bad, Bax), apoptotic executionior (Caspase3), and P53. In conclusion, HMBOX1 played important roles in occurrence of HGSOC through regulation of proliferation and apoptosis, which implied that HMBOX1 might serve as a new therapeutic target for HGSOC.

Authors+Show Affiliations

Institute of Diagnostics, School of Medicine, Shandong University, Ji'nan, Shandong, China.Institute of Diagnostics, School of Medicine, Shandong University, Ji'nan, Shandong, China.Institute of Yantai, China Agricultural University, Beijing, China.Institute of Diagnostics, School of Medicine, Shandong University, Ji'nan, Shandong, China.National Research Center for Assisted Reproductive Technology and Reproduction Genetics, Ji'nan, Shandong, China.Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong, China; Key Laboratory of Gynecologic Oncology of Shandong Province, Qilu Hospital, Shandong University, Jinan, Shandong, China.Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji'nan, Shandong, China; Key Laboratory of Gynecologic Oncology of Shandong Province, Qilu Hospital, Shandong University, Jinan, Shandong, China.Institute of Diagnostics, School of Medicine, Shandong University, Ji'nan, Shandong, China. Electronic address: lunan@sdu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29709478

Citation

Yu, Yun-Liang, et al. "Low Expression Level of HMBOX1 in High-grade Serous Ovarian Cancer Accelerates Cell Proliferation By Inhibiting Cell Apoptosis." Biochemical and Biophysical Research Communications, vol. 501, no. 2, 2018, pp. 380-386.
Yu YL, Diao NN, Li YZ, et al. Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis. Biochem Biophys Res Commun. 2018;501(2):380-386.
Yu, Y. L., Diao, N. N., Li, Y. Z., Meng, X. H., Jiao, W. L., Feng, J. B., ... Lu, N. (2018). Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis. Biochemical and Biophysical Research Communications, 501(2), pp. 380-386. doi:10.1016/j.bbrc.2018.04.203.
Yu YL, et al. Low Expression Level of HMBOX1 in High-grade Serous Ovarian Cancer Accelerates Cell Proliferation By Inhibiting Cell Apoptosis. Biochem Biophys Res Commun. 2018 06 22;501(2):380-386. PubMed PMID: 29709478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis. AU - Yu,Yun-Liang, AU - Diao,Nan-Nan, AU - Li,Yu-Zheng, AU - Meng,Xiao-Hui, AU - Jiao,Wen-Lin, AU - Feng,Jin-Bo, AU - Liu,Zhen-Ping, AU - Lu,Nan, Y1 - 2018/05/10/ PY - 2018/04/12/received PY - 2018/04/26/accepted PY - 2018/5/2/pubmed PY - 2018/11/6/medline PY - 2018/5/1/entrez KW - Apoptosis KW - HMBOX1 KW - High-grade serous ovarian cancer KW - Proliferation SP - 380 EP - 386 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 501 IS - 2 N2 - Homeobox-containing 1 (HMBOX1) has been described as a transcription factor involved in the occurrence of some tumors, but its roles in ovarian cancer have never been reported. Here we aimed to investigate the roles of HMBOX1 on high-grade serous ovarian carcinoma (HGSOC). In this present study, HMBOX1 expression was decreased in HGSOC tissues and ovarian cancer cell lines (HO8910 and A2780) compared with ovarian surface epithelial tissues or normal human ovarian surface epithelial cell line (HOSEpiC). The cell proliferation of HOSEpiC was weaker than ovarian cancer cell lines. By altering the expression of HMBOX1 in A2780 and HOSEpiC, we demonstrated that HMBOX1 inhibited the cell proliferation and promoted the cell apoptosis. Furthermore, our study revealed that HMBOX1 downregulated the expression of anti-apoptotic proteins (Bcl-2, Bcl-xL), raised the expression of pro-apoptotic-regulated proteins (Bad, Bax), apoptotic executionior (Caspase3), and P53. In conclusion, HMBOX1 played important roles in occurrence of HGSOC through regulation of proliferation and apoptosis, which implied that HMBOX1 might serve as a new therapeutic target for HGSOC. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/29709478/Low_expression_level_of_HMBOX1_in_high_grade_serous_ovarian_cancer_accelerates_cell_proliferation_by_inhibiting_cell_apoptosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(18)31000-3 DB - PRIME DP - Unbound Medicine ER -