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Antinociceptive effectiveness of Tithonia tubaeformis in a vincristine model of chemotherapy-induced painful neuropathy in mice.
Biomed Pharmacother. 2018 Jul; 103:1043-1051.BP

Abstract

BACKGROUND

Chemotherapy induced peripheral neuropathy (CIPN) is a painful side-effect of commonly used chemotherapeutic agents that profoundly impair the quality of life of patients as the current pharmacotherapeutic strategies are inefficient in providing adequate pain relief. Complementary and alternative medicine (CAM) therapies are preferred by patients with neuropathic pain as they experience insufficient control of pain with conventional medications. This study describes the antinociceptive effect of Tithonia tubaeformis (Jacq.) Cass. in a vincristine mouse model of established CIPN.

METHODS

Tithonia tubaeformis hydromethanolic extract was tested for preliminary qualitative phytochemical analysis and acute oral toxicity test in mice. The antinociceptive effect was investigated using the abdominal constriction (writhing) and tail immersion tests (25-200 mg/kg). The anti-neuropathic effect was determined in the vincristine mouse model, established by daily administration of vincristine (0.1 mg/kg/day, i.p) for consecutive 14 days. Acute treatment with Tithonia tubaeformis (100 and 200 mg/kg) and the positive control, gabapentin (75 mg/kg) was carried out on the 15th day of the last vincrsitine dose and the animals were tested for allodynia and thermal hyperalgesia at 30-120 min post extract/drug administration.

RESULTS

Vincristine produced significant temporal tactile allodynia and thermal hyperalgesia (P < 0.01 and P < 0.001 on day 7 and 14) and was maintained for the subsequent day (P < 0.001 during 30-120 min). Tithonia tubaeformis was effective in attenuating the vincristine-induced allodynia and thermal hyperalgesia at 100 mg/kg (P < 0.05, P < 0.01) and 200 mg/kg (P < 0.01, P < 0.001). Similarly, gabapentin also showed a robust antinociceptive effect in counteracting the vincristine associated behavioral alterations.

CONCLUSIONS

Tithonia tubaeformis can be an effective CAM therapeutic remedy for established CIPN due to its potential antinociceptive effect in attenuating vincristine-induced neuropathy.

Authors+Show Affiliations

Department of Pharmacy, University of Peshawar, Peshawar, Pakistan. Electronic address: noorianawaz@yahoo.com.Department of Pharmacy, University of Peshawar, Peshawar, Pakistan. Electronic address: saeedrph2000@yahoo.com.Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29710662

Citation

Nawaz, Noor Ul Ain, et al. "Antinociceptive Effectiveness of Tithonia Tubaeformis in a Vincristine Model of Chemotherapy-induced Painful Neuropathy in Mice." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 103, 2018, pp. 1043-1051.
Nawaz NUA, Saeed M, Rauf K, et al. Antinociceptive effectiveness of Tithonia tubaeformis in a vincristine model of chemotherapy-induced painful neuropathy in mice. Biomed Pharmacother. 2018;103:1043-1051.
Nawaz, N. U. A., Saeed, M., Rauf, K., Usman, M., Arif, M., Ullah, Z., & Raziq, N. (2018). Antinociceptive effectiveness of Tithonia tubaeformis in a vincristine model of chemotherapy-induced painful neuropathy in mice. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 103, 1043-1051. https://doi.org/10.1016/j.biopha.2018.04.115
Nawaz NUA, et al. Antinociceptive Effectiveness of Tithonia Tubaeformis in a Vincristine Model of Chemotherapy-induced Painful Neuropathy in Mice. Biomed Pharmacother. 2018;103:1043-1051. PubMed PMID: 29710662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive effectiveness of Tithonia tubaeformis in a vincristine model of chemotherapy-induced painful neuropathy in mice. AU - Nawaz,Noor Ul Ain, AU - Saeed,Muhammad, AU - Rauf,Khalid, AU - Usman,Muhammad, AU - Arif,Mehreen, AU - Ullah,Zaki, AU - Raziq,Naila, Y1 - 2018/04/25/ PY - 2017/12/05/received PY - 2018/04/12/revised PY - 2018/04/16/accepted PY - 2018/5/2/pubmed PY - 2018/11/14/medline PY - 2018/5/2/entrez KW - Analgesic KW - CAM therapy KW - Chemotherapy KW - Hyperalgesia KW - Neuropathy KW - Tithonia species SP - 1043 EP - 1051 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 103 N2 - BACKGROUND: Chemotherapy induced peripheral neuropathy (CIPN) is a painful side-effect of commonly used chemotherapeutic agents that profoundly impair the quality of life of patients as the current pharmacotherapeutic strategies are inefficient in providing adequate pain relief. Complementary and alternative medicine (CAM) therapies are preferred by patients with neuropathic pain as they experience insufficient control of pain with conventional medications. This study describes the antinociceptive effect of Tithonia tubaeformis (Jacq.) Cass. in a vincristine mouse model of established CIPN. METHODS: Tithonia tubaeformis hydromethanolic extract was tested for preliminary qualitative phytochemical analysis and acute oral toxicity test in mice. The antinociceptive effect was investigated using the abdominal constriction (writhing) and tail immersion tests (25-200 mg/kg). The anti-neuropathic effect was determined in the vincristine mouse model, established by daily administration of vincristine (0.1 mg/kg/day, i.p) for consecutive 14 days. Acute treatment with Tithonia tubaeformis (100 and 200 mg/kg) and the positive control, gabapentin (75 mg/kg) was carried out on the 15th day of the last vincrsitine dose and the animals were tested for allodynia and thermal hyperalgesia at 30-120 min post extract/drug administration. RESULTS: Vincristine produced significant temporal tactile allodynia and thermal hyperalgesia (P < 0.01 and P < 0.001 on day 7 and 14) and was maintained for the subsequent day (P < 0.001 during 30-120 min). Tithonia tubaeformis was effective in attenuating the vincristine-induced allodynia and thermal hyperalgesia at 100 mg/kg (P < 0.05, P < 0.01) and 200 mg/kg (P < 0.01, P < 0.001). Similarly, gabapentin also showed a robust antinociceptive effect in counteracting the vincristine associated behavioral alterations. CONCLUSIONS: Tithonia tubaeformis can be an effective CAM therapeutic remedy for established CIPN due to its potential antinociceptive effect in attenuating vincristine-induced neuropathy. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/29710662/Antinociceptive_effectiveness_of_Tithonia_tubaeformis_in_a_vincristine_model_of_chemotherapy_induced_painful_neuropathy_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)36658-1 DB - PRIME DP - Unbound Medicine ER -