Tags

Type your tag names separated by a space and hit enter

Role of sperm DNA fragmentation in male factor infertility: A systematic review.
Arab J Urol 2018; 16(1):21-34AJ

Abstract

Objective

To summarise the latest evidence on the role of sperm DNA fragmentation (SDF) in male factor infertility, as SDF has been emerging as a valuable tool for male infertility evaluation.

Methods

A search of PubMed was conducted using the keywords 'sperm DNA fragmentation' and 'male infertility'. Studies in languages other than English were excluded. All identified studies were screened and clinical studies in humans were included.

Results

In all, 150 articles were included for analysis. Current evidence supports the association between high SDF and poor reproductive outcomes for natural conception and intrauterine insemination. Although the relationship between high SDF and in vitro fertilisation and intracytoplasmic sperm injection is less clear, the negative implication of high SDF on pregnancy loss is evident. Various treatment strategies have been attempted with varying success. The predictive value of SDF testing on outcomes of natural pregnancy and assisted reproduction illustrates its value in clinical practice.

Conclusion

The significant role of SDF in male factor infertility is supported by current evidence. The beneficial role of SDF testing in selection of varicocelectomy candidates, evaluation of patients with unexplained infertility and recurrent pregnancy loss, selection of the most appropriate assisted reproductive technique with highest success rate for infertile couples, and assessment of infertile men with modifiable lifestyle factors or gonadotoxin exposure has been recently proposed.

Authors+Show Affiliations

Division of Urology, Department of Surgery, Kwong Wah Hospital, Yaumatei, Hong Kong.American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29713533

Citation

Cho, Chak-Lam, and Ashok Agarwal. "Role of Sperm DNA Fragmentation in Male Factor Infertility: a Systematic Review." Arab Journal of Urology, vol. 16, no. 1, 2018, pp. 21-34.
Cho CL, Agarwal A. Role of sperm DNA fragmentation in male factor infertility: A systematic review. Arab J Urol. 2018;16(1):21-34.
Cho, C. L., & Agarwal, A. (2018). Role of sperm DNA fragmentation in male factor infertility: A systematic review. Arab Journal of Urology, 16(1), pp. 21-34. doi:10.1016/j.aju.2017.11.002.
Cho CL, Agarwal A. Role of Sperm DNA Fragmentation in Male Factor Infertility: a Systematic Review. Arab J Urol. 2018;16(1):21-34. PubMed PMID: 29713533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of sperm DNA fragmentation in male factor infertility: A systematic review. AU - Cho,Chak-Lam, AU - Agarwal,Ashok, Y1 - 2017/12/06/ PY - 2017/11/03/received PY - 2017/11/07/accepted PY - 2018/5/2/entrez PY - 2018/5/2/pubmed PY - 2018/5/2/medline KW - ART, assisted reproductive technology KW - ASRM, American Society for Reproductive Medicine KW - Assisted reproductive technology (ART) KW - Comet, single cell gel electrophoresis assay KW - EAU, European Association of Urology KW - ICSI, intracytoplasmic sperm injection KW - IMSI, intracytoplasmic morphologically selected sperm injection KW - IUI, intrauterine insemination KW - IVF, in vitro fertilisation KW - MACS, magnetic cell sorting KW - Male infertility KW - OR, odds ratio KW - PICSI, physiological ICSI with hyaluronic acid binding assay KW - ROS, reactive oxygen species KW - RR, relative risk KW - SCD, sperm chromatin dispersion KW - SCSA, sperm chromatin structure assay KW - SDF, sperm DNA fragmentation KW - Sperm DNA fragmentation (SDF) KW - TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelling SP - 21 EP - 34 JF - Arab journal of urology JO - Arab J Urol VL - 16 IS - 1 N2 - Objective: To summarise the latest evidence on the role of sperm DNA fragmentation (SDF) in male factor infertility, as SDF has been emerging as a valuable tool for male infertility evaluation. Methods: A search of PubMed was conducted using the keywords 'sperm DNA fragmentation' and 'male infertility'. Studies in languages other than English were excluded. All identified studies were screened and clinical studies in humans were included. Results: In all, 150 articles were included for analysis. Current evidence supports the association between high SDF and poor reproductive outcomes for natural conception and intrauterine insemination. Although the relationship between high SDF and in vitro fertilisation and intracytoplasmic sperm injection is less clear, the negative implication of high SDF on pregnancy loss is evident. Various treatment strategies have been attempted with varying success. The predictive value of SDF testing on outcomes of natural pregnancy and assisted reproduction illustrates its value in clinical practice. Conclusion: The significant role of SDF in male factor infertility is supported by current evidence. The beneficial role of SDF testing in selection of varicocelectomy candidates, evaluation of patients with unexplained infertility and recurrent pregnancy loss, selection of the most appropriate assisted reproductive technique with highest success rate for infertile couples, and assessment of infertile men with modifiable lifestyle factors or gonadotoxin exposure has been recently proposed. SN - 2090-598X UR - https://www.unboundmedicine.com/medline/citation/29713533/Role_of_sperm_DNA_fragmentation_in_male_factor_infertility:_A_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2090-598X(17)30136-5 DB - PRIME DP - Unbound Medicine ER -