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Quantitative and functional change in T cells of primiparous mice following injection of benzo(a)pyrene at the second trimester of pregnancy.
Immunopharmacol Immunotoxicol. 1988; 10(2):195-217.II

Abstract

Progeny from benzo(a)pyrene (BP) exposed (150 micrograms/g body weight) primiparous mothers, injected during the second trimester of pregnancy, are severely compromised immunologically. In view of maternal-fetal associations, we studied, during pregnancy and postpartum, the quantitative and functional status of the maternal T cell population in the thymus and/or spleen. In the thymus, there is an exacerbated depression in the amounts of thymocytes, (theta +, Lyt 1+, Lyt 2+ cells) during pregnancy relative to the corn oil-injected controls, which is sustained postpartum. In the spleen, while there are inconsistencies in the level of theta + cells, The Lyt 1+ are depressed postpartum relative to virgins, but the Lyt 2+ are enhanced during pregnancy and postpartum, reaching levels greater than 700-fold of controls. In controls, while the number of Lyt 1+ cells was higher than BP-exposed mice or virgins during pregnancy, they virtually disappeared postpartum. A similar but reversed image is mirrored by the Lyt 2+ cells, i.e., they were virtually absent during pregnancy but increased postpartum. Splenic allogeneic and syngeneic mixed lymphocyte responses were subnormal. The data show that BP disrupts the maternal T cell repertoire, leading to an accumulation of Lyt 1-2+ cells, and suggest that splenic disruption may be due to changes in the differentiation potential of T precursor cells. These changes not only are most likely to affect maternal defenses, but also may have a direct bearing on the establishment of progeny immune status.

Authors+Show Affiliations

Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310-1495.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2971711

Citation

Urso, P, and R A. Johnson. "Quantitative and Functional Change in T Cells of Primiparous Mice Following Injection of Benzo(a)pyrene at the Second Trimester of Pregnancy." Immunopharmacology and Immunotoxicology, vol. 10, no. 2, 1988, pp. 195-217.
Urso P, Johnson RA. Quantitative and functional change in T cells of primiparous mice following injection of benzo(a)pyrene at the second trimester of pregnancy. Immunopharmacol Immunotoxicol. 1988;10(2):195-217.
Urso, P., & Johnson, R. A. (1988). Quantitative and functional change in T cells of primiparous mice following injection of benzo(a)pyrene at the second trimester of pregnancy. Immunopharmacology and Immunotoxicology, 10(2), 195-217.
Urso P, Johnson RA. Quantitative and Functional Change in T Cells of Primiparous Mice Following Injection of Benzo(a)pyrene at the Second Trimester of Pregnancy. Immunopharmacol Immunotoxicol. 1988;10(2):195-217. PubMed PMID: 2971711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative and functional change in T cells of primiparous mice following injection of benzo(a)pyrene at the second trimester of pregnancy. AU - Urso,P, AU - Johnson,R A, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 195 EP - 217 JF - Immunopharmacology and immunotoxicology JO - Immunopharmacol Immunotoxicol VL - 10 IS - 2 N2 - Progeny from benzo(a)pyrene (BP) exposed (150 micrograms/g body weight) primiparous mothers, injected during the second trimester of pregnancy, are severely compromised immunologically. In view of maternal-fetal associations, we studied, during pregnancy and postpartum, the quantitative and functional status of the maternal T cell population in the thymus and/or spleen. In the thymus, there is an exacerbated depression in the amounts of thymocytes, (theta +, Lyt 1+, Lyt 2+ cells) during pregnancy relative to the corn oil-injected controls, which is sustained postpartum. In the spleen, while there are inconsistencies in the level of theta + cells, The Lyt 1+ are depressed postpartum relative to virgins, but the Lyt 2+ are enhanced during pregnancy and postpartum, reaching levels greater than 700-fold of controls. In controls, while the number of Lyt 1+ cells was higher than BP-exposed mice or virgins during pregnancy, they virtually disappeared postpartum. A similar but reversed image is mirrored by the Lyt 2+ cells, i.e., they were virtually absent during pregnancy but increased postpartum. Splenic allogeneic and syngeneic mixed lymphocyte responses were subnormal. The data show that BP disrupts the maternal T cell repertoire, leading to an accumulation of Lyt 1-2+ cells, and suggest that splenic disruption may be due to changes in the differentiation potential of T precursor cells. These changes not only are most likely to affect maternal defenses, but also may have a direct bearing on the establishment of progeny immune status. SN - 0892-3973 UR - https://www.unboundmedicine.com/medline/citation/2971711/Quantitative_and_functional_change_in_T_cells_of_primiparous_mice_following_injection_of_benzo_a_pyrene_at_the_second_trimester_of_pregnancy_ L2 - http://www.tandfonline.com/doi/full/10.3109/08923978809014333 DB - PRIME DP - Unbound Medicine ER -