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Improving influenza vaccines: challenges to effective implementation.
Curr Opin Immunol. 2018 08; 53:88-95.CO

Abstract

Influenza virus causes contagious respiratory illness and remains a major burden on healthcare systems and the economy. Seasonal influenza vaccine is the most cost-effective way to combat the disease. However, underestimation of disease severity and controversy over vaccine safety and effectiveness hampers public confidence in vaccination. Action is needed to restore public confidence and improve vaccine uptake. Tailoring seasonal influenza vaccines according to immune responsiveness and infection/vaccination history of different populations can improve vaccine efficacy and effectiveness. Steady progress has been made in next generation influenza vaccine designs aiming at broad and long-lasting protective immunity in pre-clinical and clinical studies. However, substantial research and regulatory effort is required before reaching the goal of a truly universal vaccine.

Authors+Show Affiliations

Influenza Centre, Department of Clinical Science, University of Bergen, Norway; K.G. Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Norway.Influenza Centre, Department of Clinical Science, University of Bergen, Norway; K.G. Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Norway.Influenza Centre, Department of Clinical Science, University of Bergen, Norway; K.G. Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Norway.Influenza Centre, Department of Clinical Science, University of Bergen, Norway; K.G. Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Norway; Department of Research and Development, Haukeland University Hospital, Bergen, Norway. Electronic address: rebecca.cox@uib.no.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29719276

Citation

Zhou, Fan, et al. "Improving Influenza Vaccines: Challenges to Effective Implementation." Current Opinion in Immunology, vol. 53, 2018, pp. 88-95.
Zhou F, Trieu MC, Davies R, et al. Improving influenza vaccines: challenges to effective implementation. Curr Opin Immunol. 2018;53:88-95.
Zhou, F., Trieu, M. C., Davies, R., & Cox, R. J. (2018). Improving influenza vaccines: challenges to effective implementation. Current Opinion in Immunology, 53, 88-95. https://doi.org/10.1016/j.coi.2018.04.010
Zhou F, et al. Improving Influenza Vaccines: Challenges to Effective Implementation. Curr Opin Immunol. 2018;53:88-95. PubMed PMID: 29719276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improving influenza vaccines: challenges to effective implementation. AU - Zhou,Fan, AU - Trieu,Mai-Chi, AU - Davies,Richard, AU - Cox,Rebecca Jane, Y1 - 2018/04/30/ PY - 2018/02/23/received PY - 2018/04/08/revised PY - 2018/04/13/accepted PY - 2018/5/3/pubmed PY - 2019/6/27/medline PY - 2018/5/3/entrez SP - 88 EP - 95 JF - Current opinion in immunology JO - Curr Opin Immunol VL - 53 N2 - Influenza virus causes contagious respiratory illness and remains a major burden on healthcare systems and the economy. Seasonal influenza vaccine is the most cost-effective way to combat the disease. However, underestimation of disease severity and controversy over vaccine safety and effectiveness hampers public confidence in vaccination. Action is needed to restore public confidence and improve vaccine uptake. Tailoring seasonal influenza vaccines according to immune responsiveness and infection/vaccination history of different populations can improve vaccine efficacy and effectiveness. Steady progress has been made in next generation influenza vaccine designs aiming at broad and long-lasting protective immunity in pre-clinical and clinical studies. However, substantial research and regulatory effort is required before reaching the goal of a truly universal vaccine. SN - 1879-0372 UR - https://www.unboundmedicine.com/medline/citation/29719276/Improving_influenza_vaccines:_challenges_to_effective_implementation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-7915(18)30030-X DB - PRIME DP - Unbound Medicine ER -