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Multicenter trial of a monophasic oral contraceptive containing ethinyl estradiol and desogestrel.
Acta Obstet Gynecol Scand. 1988; 67(2):171-4.AO

Abstract

A clinical trial was conducted at 47 centers in 11 countries to assess the efficacy and acceptability of a monophasic oral contraceptive containing 30 micrograms ethinyl estradiol and 150 micrograms desogestrel. 1,613 women took part for a total of 23,258 cycles. One pregnancy occurred in a cycle where two consecutive tablets had been forgotten. Cycle control was excellent, with reported decreases in the duration and amount of withdrawal bleeding during consecutive treatment cycles and a low incidence of irregular bleeding. Blood pressure was not affected during 2 years of use. The incidence of minor side effects was already low in the first treatment cycle and decreased further in the subsequent cycles. The combination (Marvelon) was shown to be a very reliable and acceptable oral contraceptive.

Authors+Show Affiliations

Organon International B.V., Oss, The Netherlands.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

2972160

Citation

Rekers, H. "Multicenter Trial of a Monophasic Oral Contraceptive Containing Ethinyl Estradiol and Desogestrel." Acta Obstetricia Et Gynecologica Scandinavica, vol. 67, no. 2, 1988, pp. 171-4.
Rekers H. Multicenter trial of a monophasic oral contraceptive containing ethinyl estradiol and desogestrel. Acta Obstet Gynecol Scand. 1988;67(2):171-4.
Rekers, H. (1988). Multicenter trial of a monophasic oral contraceptive containing ethinyl estradiol and desogestrel. Acta Obstetricia Et Gynecologica Scandinavica, 67(2), 171-4.
Rekers H. Multicenter Trial of a Monophasic Oral Contraceptive Containing Ethinyl Estradiol and Desogestrel. Acta Obstet Gynecol Scand. 1988;67(2):171-4. PubMed PMID: 2972160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multicenter trial of a monophasic oral contraceptive containing ethinyl estradiol and desogestrel. A1 - Rekers,H, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez KW - Biology KW - Clinical Research KW - Contraception KW - Contraception Continuation KW - Contraception Failure KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin--side effects KW - Contraceptive Agents--side effects KW - Contraceptive Methods KW - Contraceptive Usage KW - Endocrine System KW - Family Planning KW - Hormones--side effects KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Physiology KW - Progestational Hormones KW - Progesterone--side effects KW - Reproductive Control Agents KW - Research Methodology SP - 171 EP - 4 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 67 IS - 2 N2 - A clinical trial was conducted at 47 centers in 11 countries to assess the efficacy and acceptability of a monophasic oral contraceptive containing 30 micrograms ethinyl estradiol and 150 micrograms desogestrel. 1,613 women took part for a total of 23,258 cycles. One pregnancy occurred in a cycle where two consecutive tablets had been forgotten. Cycle control was excellent, with reported decreases in the duration and amount of withdrawal bleeding during consecutive treatment cycles and a low incidence of irregular bleeding. Blood pressure was not affected during 2 years of use. The incidence of minor side effects was already low in the first treatment cycle and decreased further in the subsequent cycles. The combination (Marvelon) was shown to be a very reliable and acceptable oral contraceptive. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/2972160/Multicenter_trial_of_a_monophasic_oral_contraceptive_containing_ethinyl_estradiol_and_desogestrel_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6349&date=1988&volume=67&issue=2&spage=171 DB - PRIME DP - Unbound Medicine ER -