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Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway.
Int J Med Sci 2018; 15(6):645-652IJ

Abstract

The highly conserved Hippo signaling pathway is one of the most important pathways involved in tumorigenesis and progress. Previous studies show that YAP, the transcriptional coactivator of Hippo pathway, is expressed highly in many clinical bladder cancer tissues and plays crucial role on bladder cancer progress. To find the YAP-specific target drug and its molecular mechanism in bladder cancer, we apply Verteporfin (VP), a YAP specific inhibitor to function as anti-bladder cancer drug and discover that VP is able to inhibit bladder cancer cell growth and invasion in a dosage dependent manner. Moreover, we demonstrate that VP may inhibit bladder cancer cell growth and invasion via repressing target genes' expression of the Hippo signaling pathway. In further study, we provide evidence that VP is able to inhibit excessive YAP induced bladder cancer cell growth and invasion. To address the repressive function of VP against YAP in bladder cancer, we check the target genes' expression and find VP can dramatically repress YAP overexpression induced Hippo pathway target genes' expression. Taken together, we discover that VP inhibits YAP-induced bladder cancer cell growth and invasion via repressing the target genes' expression of Hippo signaling pathway.

Authors+Show Affiliations

State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen 518039, PR China. Department of Biomedical Sciences, City University of Hong Kong, Hong Kong.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen 518039, PR China. Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou 515063, PR China.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen 518039, PR China.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen 518039, PR China.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center of Shenzhen University, Shenzhen 518039, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29725256

Citation

Dong, Liang, et al. "Verteporfin Inhibits YAP-induced Bladder Cancer Cell Growth and Invasion Via Hippo Signaling Pathway." International Journal of Medical Sciences, vol. 15, no. 6, 2018, pp. 645-652.
Dong L, Lin F, Wu W, et al. Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway. Int J Med Sci. 2018;15(6):645-652.
Dong, L., Lin, F., Wu, W., Liu, Y., & Huang, W. (2018). Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway. International Journal of Medical Sciences, 15(6), pp. 645-652. doi:10.7150/ijms.23460.
Dong L, et al. Verteporfin Inhibits YAP-induced Bladder Cancer Cell Growth and Invasion Via Hippo Signaling Pathway. Int J Med Sci. 2018;15(6):645-652. PubMed PMID: 29725256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway. AU - Dong,Liang, AU - Lin,Fan, AU - Wu,Wanjun, AU - Liu,Yuchen, AU - Huang,Weiren, Y1 - 2018/04/03/ PY - 2017/10/23/received PY - 2018/03/02/accepted PY - 2018/5/5/entrez PY - 2018/5/5/pubmed PY - 2018/9/18/medline KW - Verteporfin KW - YAP KW - bladder cancer KW - cell growth and invasion SP - 645 EP - 652 JF - International journal of medical sciences JO - Int J Med Sci VL - 15 IS - 6 N2 - The highly conserved Hippo signaling pathway is one of the most important pathways involved in tumorigenesis and progress. Previous studies show that YAP, the transcriptional coactivator of Hippo pathway, is expressed highly in many clinical bladder cancer tissues and plays crucial role on bladder cancer progress. To find the YAP-specific target drug and its molecular mechanism in bladder cancer, we apply Verteporfin (VP), a YAP specific inhibitor to function as anti-bladder cancer drug and discover that VP is able to inhibit bladder cancer cell growth and invasion in a dosage dependent manner. Moreover, we demonstrate that VP may inhibit bladder cancer cell growth and invasion via repressing target genes' expression of the Hippo signaling pathway. In further study, we provide evidence that VP is able to inhibit excessive YAP induced bladder cancer cell growth and invasion. To address the repressive function of VP against YAP in bladder cancer, we check the target genes' expression and find VP can dramatically repress YAP overexpression induced Hippo pathway target genes' expression. Taken together, we discover that VP inhibits YAP-induced bladder cancer cell growth and invasion via repressing the target genes' expression of Hippo signaling pathway. SN - 1449-1907 UR - https://www.unboundmedicine.com/medline/citation/29725256/Verteporfin_inhibits_YAP_induced_bladder_cancer_cell_growth_and_invasion_via_Hippo_signaling_pathway_ L2 - http://www.medsci.org/v15p0645.htm DB - PRIME DP - Unbound Medicine ER -