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A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia.
Eur J Nutr. 2019 Jun; 58(4):1615-1624.EJ

Abstract

PURPOSE

The primary and secondary objectives were to investigate the triglyceride (TG) and LDL-cholesterol (LDL-C) lowering effects of a spread with added plant sterols (PS) and fish oil as compared to a placebo spread.

METHODS

This study had a randomized, double-blind, placebo-controlled, parallel group design with two intervention arms. Following a 2-week placebo run-in period, 260 healthy individuals with modestly elevated blood TG (≥ 1.4 mmol/L) and LDL-C (≥ 3.4 mmol/L) concentrations consumed either the placebo or intervention spread for 4 weeks. The intervention spread contained 2.0 g/day PS and 1.0 g/day eicosapentaenoic acid (EPA) + docosahexanoic acid (DHA) from fish oil. Fasting serum lipids and apolipoproteins (Apo) (exploratory) were measured at the end of the run-in and intervention phases.

RESULTS

Four-week consumption of the intervention spread resulted in significantly lower TG (- 10.6%, 95% CI - 16.0 to - 4.9%; P < 0.001) and LDL-C concentrations (- 5.2%; 95% CI - 7.8 to - 2.4%) as compared to placebo. Total cholesterol (- 3.9%; 95% CI - 6.1 to - 1.5%), non-HDL-C (- 5.4%; 95% CI - 8.1 to - 2.7%), remnant-cholesterol (- 8.1%; 95% CI - 3.4 to - 12.5%), ApoAII (- 2.9%; 95% CI - 5.5 to - 0.2%), ApoCIII (- 7.7%; 95% CI - 12.1 to - 3.1%) and ApoB (- 3.2%; 95% CI - 5.9 to - 0.4%) concentrations were also significantly lower, as compared to placebo. No significant treatment effects were found for HDL-cholesterol, ApoAI, ApoCII, Apo E or ApoB/ApoAI.

CONCLUSIONS

Four-week consumption of the intervention spread led to significant and clinically relevant decreases in serum TG, LDL-C and other blood lipid concentrations. The study was registered at clinicaltrials.gov (NCT02728583).

Authors+Show Affiliations

Unilever Research and Development Vlaardingen, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands. wendy.blom@unilever.com. , PO Box 114, 3130 AC, Vlaardingen, The Netherlands. wendy.blom@unilever.com.Unilever Research and Development Vlaardingen, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands.Unilever Research and Development Vlaardingen, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands.Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.Unilever Research and Development Vlaardingen, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29725824

Citation

Blom, Wendy A M., et al. "A Low-fat Spread With Added Plant Sterols and Fish Omega-3 Fatty Acids Lowers Serum Triglyceride and LDL-cholesterol Concentrations in Individuals With Modest Hypercholesterolaemia and Hypertriglyceridaemia." European Journal of Nutrition, vol. 58, no. 4, 2019, pp. 1615-1624.
Blom WAM, Koppenol WP, Hiemstra H, et al. A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. Eur J Nutr. 2019;58(4):1615-1624.
Blom, W. A. M., Koppenol, W. P., Hiemstra, H., Stojakovic, T., Scharnagl, H., & Trautwein, E. A. (2019). A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. European Journal of Nutrition, 58(4), 1615-1624. https://doi.org/10.1007/s00394-018-1706-1
Blom WAM, et al. A Low-fat Spread With Added Plant Sterols and Fish Omega-3 Fatty Acids Lowers Serum Triglyceride and LDL-cholesterol Concentrations in Individuals With Modest Hypercholesterolaemia and Hypertriglyceridaemia. Eur J Nutr. 2019;58(4):1615-1624. PubMed PMID: 29725824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. AU - Blom,Wendy A M, AU - Koppenol,Wieneke P, AU - Hiemstra,Harry, AU - Stojakovic,Tatjana, AU - Scharnagl,Hubert, AU - Trautwein,Elke A, Y1 - 2018/05/03/ PY - 2018/02/06/received PY - 2018/04/27/accepted PY - 2018/5/5/pubmed PY - 2020/1/23/medline PY - 2018/5/5/entrez KW - DHA KW - EPA KW - Fish oil KW - Human intervention KW - LDL-cholesterol KW - Plant sterols KW - Triglyceride SP - 1615 EP - 1624 JF - European journal of nutrition JO - Eur J Nutr VL - 58 IS - 4 N2 - PURPOSE: The primary and secondary objectives were to investigate the triglyceride (TG) and LDL-cholesterol (LDL-C) lowering effects of a spread with added plant sterols (PS) and fish oil as compared to a placebo spread. METHODS: This study had a randomized, double-blind, placebo-controlled, parallel group design with two intervention arms. Following a 2-week placebo run-in period, 260 healthy individuals with modestly elevated blood TG (≥ 1.4 mmol/L) and LDL-C (≥ 3.4 mmol/L) concentrations consumed either the placebo or intervention spread for 4 weeks. The intervention spread contained 2.0 g/day PS and 1.0 g/day eicosapentaenoic acid (EPA) + docosahexanoic acid (DHA) from fish oil. Fasting serum lipids and apolipoproteins (Apo) (exploratory) were measured at the end of the run-in and intervention phases. RESULTS: Four-week consumption of the intervention spread resulted in significantly lower TG (- 10.6%, 95% CI - 16.0 to - 4.9%; P < 0.001) and LDL-C concentrations (- 5.2%; 95% CI - 7.8 to - 2.4%) as compared to placebo. Total cholesterol (- 3.9%; 95% CI - 6.1 to - 1.5%), non-HDL-C (- 5.4%; 95% CI - 8.1 to - 2.7%), remnant-cholesterol (- 8.1%; 95% CI - 3.4 to - 12.5%), ApoAII (- 2.9%; 95% CI - 5.5 to - 0.2%), ApoCIII (- 7.7%; 95% CI - 12.1 to - 3.1%) and ApoB (- 3.2%; 95% CI - 5.9 to - 0.4%) concentrations were also significantly lower, as compared to placebo. No significant treatment effects were found for HDL-cholesterol, ApoAI, ApoCII, Apo E or ApoB/ApoAI. CONCLUSIONS: Four-week consumption of the intervention spread led to significant and clinically relevant decreases in serum TG, LDL-C and other blood lipid concentrations. The study was registered at clinicaltrials.gov (NCT02728583). SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/29725824/A_low_fat_spread_with_added_plant_sterols_and_fish_omega_3_fatty_acids_lowers_serum_triglyceride_and_LDL_cholesterol_concentrations_in_individuals_with_modest_hypercholesterolaemia_and_hypertriglyceridaemia_ L2 - https://dx.doi.org/10.1007/s00394-018-1706-1 DB - PRIME DP - Unbound Medicine ER -