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Bioactive mushroom polysaccharides as antitumor: an overview.
Nat Prod Res. 2019 Sep; 33(18):2668-2680.NP

Abstract

Immuno-therapies are gaining more importance to treat certain forms of cancer. The goal of therapies is to enhance person's own IgG, IgA, IgM, IgD, IgE and macrophages to combat with neoplastic cells hence the effectiveness of the immune system. Since, early civilization mushrooms are considered as potent food as well as medicine. Mushrooms are well known for their bioactive compounds such as chizophyllan, lentinan, grifolan, PSP (polysaccharide-peptide complex) and PSK (polysaccharide-protein complex) which are considered as medicines against melignancy. They prevent oncogenesis by the direct effect on tumor metastasis and exhibits antitumor effects by the induction of immune response in host. Mushroom polysaccharides have promising future for treatment of cancers due to their mode of action and efficacy. Also there are some hurdles during this treatment, but it will start a new era of safer and effective medicine based on mushroom polysaccharides.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Pandya U
a Department of Microbiology , Samarpan Science and Commerce College , Gandhinagar , India.
Dhuldhaj U
b School of Life Sciences , Swami Ramanand Teerth Marathwada University , Nanded , India.
Sahay NS
c Sadbhav SRISTI Sanshodhan Natural Products Laboratory , SRISTI, AES Boys Hostel Campus , Navrangpura, Ahmedabad , India.

MeSH

AgaricalesAnimalsAntineoplastic AgentsHumansImmunologic FactorsImmunotherapyLentinanNeoplasmsPolysaccharidesProteoglycansbeta-Glucans

Pub Type(s)

Journal Article
Video-Audio Media

Language

eng

PubMed ID

29726720

Citation

Pandya, Urja, et al. "Bioactive Mushroom Polysaccharides as Antitumor: an Overview." Natural Product Research, vol. 33, no. 18, 2019, pp. 2668-2680.
Pandya U, Dhuldhaj U, Sahay NS. Bioactive mushroom polysaccharides as antitumor: an overview. Nat Prod Res. 2019;33(18):2668-2680.
Pandya, U., Dhuldhaj, U., & Sahay, N. S. (2019). Bioactive mushroom polysaccharides as antitumor: an overview. Natural Product Research, 33(18), 2668-2680. https://doi.org/10.1080/14786419.2018.1466129
Pandya U, Dhuldhaj U, Sahay NS. Bioactive Mushroom Polysaccharides as Antitumor: an Overview. Nat Prod Res. 2019;33(18):2668-2680. PubMed PMID: 29726720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive mushroom polysaccharides as antitumor: an overview. AU - Pandya,Urja, AU - Dhuldhaj,Umesh, AU - Sahay,Nirmal S, Y1 - 2018/05/04/ PY - 2018/5/5/pubmed PY - 2019/9/21/medline PY - 2018/5/5/entrez KW - Antitumor KW - immuno-therapy KW - mushroom KW - polysaccharides SP - 2668 EP - 2680 JF - Natural product research JO - Nat Prod Res VL - 33 IS - 18 N2 - Immuno-therapies are gaining more importance to treat certain forms of cancer. The goal of therapies is to enhance person's own IgG, IgA, IgM, IgD, IgE and macrophages to combat with neoplastic cells hence the effectiveness of the immune system. Since, early civilization mushrooms are considered as potent food as well as medicine. Mushrooms are well known for their bioactive compounds such as chizophyllan, lentinan, grifolan, PSP (polysaccharide-peptide complex) and PSK (polysaccharide-protein complex) which are considered as medicines against melignancy. They prevent oncogenesis by the direct effect on tumor metastasis and exhibits antitumor effects by the induction of immune response in host. Mushroom polysaccharides have promising future for treatment of cancers due to their mode of action and efficacy. Also there are some hurdles during this treatment, but it will start a new era of safer and effective medicine based on mushroom polysaccharides. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/29726720/Bioactive_mushroom_polysaccharides_as_antitumor:_an_overview_ DB - PRIME DP - Unbound Medicine ER -