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Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy - Tainan birth cohort study (TBCS).
Sci Total Environ. 2018 Apr 01; 619-620:1058-1065.ST

Abstract

An increasing number of studies have revealed that phthalate exposure alters thyroid hormone homeostasis in the general population, but there is insufficient evidence of the effect of longitudinal maternal phthalate exposure on maternal and fetal thyroid hormones during pregnancy. We longitudinally assessed the effect of prenatal phthalate exposure in pregnant women on umbilical cord and maternal thyroid hormones at three trimesters during pregnancy. We recruited 98 pregnant women and collected urine and blood samples at three trimesters in an obstetrics clinic in Southern Taiwan from 2013 to 2014. We analyzed the concentrations of 11 urinary phthalate metabolites, including monoethylhexyl phthalate, mono-(2-ethyl-5-oxo-hexyl) phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl phthalate, monoisobutyl phthalate (MiBP), monoethyl phthalate (MEP), using online liquid chromatography-tandem mass spectrometry. The cord and maternal serum levels of thyroxine (T4), free T4, triiodothyronine (T3), thyroid-stimulating hormone (TSH), and thyroxine-binding globulin were measured using an electrochemiluminescence immunoassay. A mixed-model analysis was utilized to assess the effect of longitudinal phthalate exposure on thyroid hormones and adjusted for significant covariates. We found that urinary MiBP (β=-0.065, 95% confidence interval (CI): -0.124, -0.005), and MEOHP (β=-0.083, 95% CI: -0.157, -0.009) were significantly negatively associated with serum TSH. Urinary MECPP was inversely related to serum T3 (β=-0.027, 95% CI: -0.047, -0.006). Urinary MEP (β=0.014, 95% CI: -0.001, 0.028) and MiBP (β=0.033, 95% CI: 0.018, 0.049) were positively related to free T4. We found that cord serum T3 (β=0.067, 95% CI: 0.003, 0.131) and free T4 (β=0.031, 95% CI: 0.001, 0.062) levels had significant positive associations with maternal ΣDBPm levels at the second trimester. We concluded that different phthalates exposure windows during gestation may alter cord and serum thyroid hormone homoeostasis.

Authors+Show Affiliations

School of Public Health, National Defense Medical Center, Taipei, Taiwan.Department of Obstetric and Gynecology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan.Center for Environmental and Respiratory Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. Electronic address: pchuang@nhri.org.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29734584

Citation

Huang, Han-Bin, et al. "Longitudinal Assessment of Prenatal Phthalate Exposure On Serum and Cord Thyroid Hormones Homeostasis During Pregnancy - Tainan Birth Cohort Study (TBCS)." The Science of the Total Environment, vol. 619-620, 2018, pp. 1058-1065.
Huang HB, Kuo PL, Chang JW, et al. Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy - Tainan birth cohort study (TBCS). Sci Total Environ. 2018;619-620:1058-1065.
Huang, H. B., Kuo, P. L., Chang, J. W., Jaakkola, J. J. K., Liao, K. W., & Huang, P. C. (2018). Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy - Tainan birth cohort study (TBCS). The Science of the Total Environment, 619-620, 1058-1065. https://doi.org/10.1016/j.scitotenv.2017.11.048
Huang HB, et al. Longitudinal Assessment of Prenatal Phthalate Exposure On Serum and Cord Thyroid Hormones Homeostasis During Pregnancy - Tainan Birth Cohort Study (TBCS). Sci Total Environ. 2018 Apr 1;619-620:1058-1065. PubMed PMID: 29734584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal assessment of prenatal phthalate exposure on serum and cord thyroid hormones homeostasis during pregnancy - Tainan birth cohort study (TBCS). AU - Huang,Han-Bin, AU - Kuo,Pao-Lin, AU - Chang,Jung-Wei, AU - Jaakkola,Jouni J K, AU - Liao,Kai-Wei, AU - Huang,Po-Chin, Y1 - 2017/11/29/ PY - 2017/08/24/received PY - 2017/10/23/revised PY - 2017/11/04/accepted PY - 2018/5/9/entrez PY - 2018/5/8/pubmed PY - 2018/6/8/medline KW - Cord blood KW - Phthalate metabolites KW - Pregnant women KW - Taiwanese KW - Thyroid hormones KW - Urine SP - 1058 EP - 1065 JF - The Science of the total environment JO - Sci Total Environ VL - 619-620 N2 - An increasing number of studies have revealed that phthalate exposure alters thyroid hormone homeostasis in the general population, but there is insufficient evidence of the effect of longitudinal maternal phthalate exposure on maternal and fetal thyroid hormones during pregnancy. We longitudinally assessed the effect of prenatal phthalate exposure in pregnant women on umbilical cord and maternal thyroid hormones at three trimesters during pregnancy. We recruited 98 pregnant women and collected urine and blood samples at three trimesters in an obstetrics clinic in Southern Taiwan from 2013 to 2014. We analyzed the concentrations of 11 urinary phthalate metabolites, including monoethylhexyl phthalate, mono-(2-ethyl-5-oxo-hexyl) phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl phthalate, monoisobutyl phthalate (MiBP), monoethyl phthalate (MEP), using online liquid chromatography-tandem mass spectrometry. The cord and maternal serum levels of thyroxine (T4), free T4, triiodothyronine (T3), thyroid-stimulating hormone (TSH), and thyroxine-binding globulin were measured using an electrochemiluminescence immunoassay. A mixed-model analysis was utilized to assess the effect of longitudinal phthalate exposure on thyroid hormones and adjusted for significant covariates. We found that urinary MiBP (β=-0.065, 95% confidence interval (CI): -0.124, -0.005), and MEOHP (β=-0.083, 95% CI: -0.157, -0.009) were significantly negatively associated with serum TSH. Urinary MECPP was inversely related to serum T3 (β=-0.027, 95% CI: -0.047, -0.006). Urinary MEP (β=0.014, 95% CI: -0.001, 0.028) and MiBP (β=0.033, 95% CI: 0.018, 0.049) were positively related to free T4. We found that cord serum T3 (β=0.067, 95% CI: 0.003, 0.131) and free T4 (β=0.031, 95% CI: 0.001, 0.062) levels had significant positive associations with maternal ΣDBPm levels at the second trimester. We concluded that different phthalates exposure windows during gestation may alter cord and serum thyroid hormone homoeostasis. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/29734584/Longitudinal_assessment_of_prenatal_phthalate_exposure_on_serum_and_cord_thyroid_hormones_homeostasis_during_pregnancy___Tainan_birth_cohort_study__TBCS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(17)33106-6 DB - PRIME DP - Unbound Medicine ER -