Tags

Type your tag names separated by a space and hit enter

Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater.
J Gastrointest Surg 2018; 22(7):1171-1178JG

Abstract

OBJECTIVES

To investigate immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of ampulla of Vater and identify clinicopathological characteristics associated with the histological types and patient survival.

METHODS

Immunohistochemical markers included MUC1, MUC2, MUC5AC, CDX2, CK7, and CK20. The data were analyzed by univariate and multivariate methods. The two-step cluster method was used to determine the best immunohistochemical markers to discriminate the intestinal from the pancreatobiliary type.

RESULTS

This study identified 9 (33.3%) intestinal and 21 (66.7%) pancreatobiliary tumors. CK7 and CDX2 achieved the highest value (= 1) as predictor markers, while CK20, MUC1, and MUC2 showed degrees of importance equal to 0.77, 0.71, and 0.68, respectively. MUC5AC did not reach 0.50 of importance. In the univariate analysis, lymph node involvement, staging (TNM), and angiolymphatic and perineural invasions were associated with histological types. The independent clinicopathological variable in the multivariate model to predict the histological type was angiolymphatic invasion (p = 0.005), OR = 17 (95% CI 2.33 to 123.83). The final model showed positive nodes (N1) associated with shorter survival (HR = 9.5; p = 0.006). Overall survival at 12, 36, and 60 months was 88.5, 67.0, and 47.6%, respectively.

CONCLUSIONS

CDX2 and CK7 were the immunohistochemical markers that best discriminated the intestinal from the pancreatobiliary type. Lymph node involvement had a high impact on survival and proved to be more frequent in the pancreatobiliary type.

Authors+Show Affiliations

Department of Surgery, Medical School, UFMG, Belo Horizonte, Rua Sergipe, 67 apto 2401, Bairro Funcionários, Belo Horizonte, CEP 30130 170, Brazil.Department of Epidemiology, Medical School, UFMG, Belo Horizonte, Minas Gerais, Brazil.Department of Histopathology, Medical School, UFMG, Belo Horizonte, Minas Gerais, Brazil.Department of Surgery, Medical School, UFMG, Belo Horizonte, Rua Sergipe, 67 apto 2401, Bairro Funcionários, Belo Horizonte, CEP 30130 170, Brazil.Department of Histopathology, Medical School, UFMG, Belo Horizonte, Minas Gerais, Brazil.Department of Surgery, Medical School, UFMG, Belo Horizonte, Rua Sergipe, 67 apto 2401, Bairro Funcionários, Belo Horizonte, CEP 30130 170, Brazil. vivianresende.ufmg@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29736668

Citation

da Silveira Santos, João Paulo Lemos, et al. "Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of the Ampulla of Vater." Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, vol. 22, no. 7, 2018, pp. 1171-1178.
da Silveira Santos JPL, Machado CJ, Junior EP, et al. Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater. J Gastrointest Surg. 2018;22(7):1171-1178.
da Silveira Santos, J. P. L., Machado, C. J., Junior, E. P., Rodrigues, J. B. S. R., Vidigal, P. T., & Resende, V. (2018). Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater. Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, 22(7), pp. 1171-1178. doi:10.1007/s11605-018-3797-7.
da Silveira Santos JPL, et al. Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of the Ampulla of Vater. J Gastrointest Surg. 2018;22(7):1171-1178. PubMed PMID: 29736668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater. AU - da Silveira Santos,João Paulo Lemos, AU - Machado,Carla Jorge, AU - Junior,Eduardo Paulino, AU - Rodrigues,João Bernardo Sancio Rocha, AU - Vidigal,Paula Teixeira, AU - Resende,Vivian, Y1 - 2018/05/07/ PY - 2018/03/16/received PY - 2018/04/24/accepted PY - 2018/5/8/pubmed PY - 2019/9/10/medline PY - 2018/5/9/entrez KW - Adenocarcinoma KW - Ampulla of Vater KW - Immunohistochemistry KW - Survival SP - 1171 EP - 1178 JF - Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract JO - J. Gastrointest. Surg. VL - 22 IS - 7 N2 - OBJECTIVES: To investigate immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of ampulla of Vater and identify clinicopathological characteristics associated with the histological types and patient survival. METHODS: Immunohistochemical markers included MUC1, MUC2, MUC5AC, CDX2, CK7, and CK20. The data were analyzed by univariate and multivariate methods. The two-step cluster method was used to determine the best immunohistochemical markers to discriminate the intestinal from the pancreatobiliary type. RESULTS: This study identified 9 (33.3%) intestinal and 21 (66.7%) pancreatobiliary tumors. CK7 and CDX2 achieved the highest value (= 1) as predictor markers, while CK20, MUC1, and MUC2 showed degrees of importance equal to 0.77, 0.71, and 0.68, respectively. MUC5AC did not reach 0.50 of importance. In the univariate analysis, lymph node involvement, staging (TNM), and angiolymphatic and perineural invasions were associated with histological types. The independent clinicopathological variable in the multivariate model to predict the histological type was angiolymphatic invasion (p = 0.005), OR = 17 (95% CI 2.33 to 123.83). The final model showed positive nodes (N1) associated with shorter survival (HR = 9.5; p = 0.006). Overall survival at 12, 36, and 60 months was 88.5, 67.0, and 47.6%, respectively. CONCLUSIONS: CDX2 and CK7 were the immunohistochemical markers that best discriminated the intestinal from the pancreatobiliary type. Lymph node involvement had a high impact on survival and proved to be more frequent in the pancreatobiliary type. SN - 1873-4626 UR - https://www.unboundmedicine.com/medline/citation/29736668/Immunohistochemical_Predictors_for_Intestinal_and_Pancreatobiliary_Types_of_Adenocarcinoma_of_The_Ampulla_of_Vater_ L2 - https://dx.doi.org/10.1007/s11605-018-3797-7 DB - PRIME DP - Unbound Medicine ER -