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C19-Norditerpenoid Alkaloids from Aconitum szechenyianum.
Molecules. 2018 May 08; 23(5)M

Abstract

Three new C19-norditerpenoid alkaloids (1⁻3), along with two known C19-norditerpenoid alkaloids (4,5), have been isolated from Aconitum szechenyianum. Based on extensive spectroscopic techniques (1D, 2D-NMR, IR, and MS) and chemical methods, their structures were established as szechenyianine D (1), szechenyianine E (2), szechenyianine F (3), 8-O-methyl-14-benzoylaconine (4), and spicatine A (5). The immunosuppressive effects of compounds 1⁻5 were studied using a ConA-induced or LPS-induced splenocyte proliferation model. In vitro tests showed that Compounds 2, 4, and 5 suppressed ConA-induced or LPS-induced splenocyte proliferation in a concentration-dependent manner. The CC50/IC50 values of 2, 4, and 5 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis.

Authors+Show Affiliations

The College of Life Sciences, Northwest University, Xi'an 710069, China. songbei168@126.com. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China. songbei168@126.com.Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. jin872459317@126.com.The College of Life Sciences, Northwest University, Xi'an 710069, China. lyz1990yeah@163.com.Shaanxi Institute for Food and Drug Control, Xi'an 710065, China. wf88-88@163.com.Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. yangyifu@mail.shcnc.ac.cn.Department of Pharmacy, Xi'an Medical University, Xi'an 710021, China. polaris_101025@163.com.Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China. songxiaom@126.com.Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China. jlliu@nwu.edu.cn.The College of Life Sciences, Northwest University, Xi'an 710069, China. liuxingjian1981@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29738430

Citation

Song, Bei, et al. "C19-Norditerpenoid Alkaloids From Aconitum Szechenyianum." Molecules (Basel, Switzerland), vol. 23, no. 5, 2018.
Song B, Jin B, Li Y, et al. C19-Norditerpenoid Alkaloids from Aconitum szechenyianum. Molecules. 2018;23(5).
Song, B., Jin, B., Li, Y., Wang, F., Yang, Y., Cui, Y., Song, X., Yue, Z., & Liu, J. (2018). C19-Norditerpenoid Alkaloids from Aconitum szechenyianum. Molecules (Basel, Switzerland), 23(5). https://doi.org/10.3390/molecules23051108
Song B, et al. C19-Norditerpenoid Alkaloids From Aconitum Szechenyianum. Molecules. 2018 May 8;23(5) PubMed PMID: 29738430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C19-Norditerpenoid Alkaloids from Aconitum szechenyianum. AU - Song,Bei, AU - Jin,Bingliang, AU - Li,Yuze, AU - Wang,Fei, AU - Yang,Yifu, AU - Cui,Yuwen, AU - Song,Xiaomei, AU - Yue,Zhenggang, AU - Liu,Jianli, Y1 - 2018/05/08/ PY - 2018/03/05/received PY - 2018/04/25/revised PY - 2018/04/25/accepted PY - 2018/5/9/entrez PY - 2018/5/9/pubmed PY - 2018/9/21/medline KW - Aconitum szechenyianum KW - C19-norditerpenoid alkaloids KW - immunosuppressive effects JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 5 N2 - Three new C19-norditerpenoid alkaloids (1⁻3), along with two known C19-norditerpenoid alkaloids (4,5), have been isolated from Aconitum szechenyianum. Based on extensive spectroscopic techniques (1D, 2D-NMR, IR, and MS) and chemical methods, their structures were established as szechenyianine D (1), szechenyianine E (2), szechenyianine F (3), 8-O-methyl-14-benzoylaconine (4), and spicatine A (5). The immunosuppressive effects of compounds 1⁻5 were studied using a ConA-induced or LPS-induced splenocyte proliferation model. In vitro tests showed that Compounds 2, 4, and 5 suppressed ConA-induced or LPS-induced splenocyte proliferation in a concentration-dependent manner. The CC50/IC50 values of 2, 4, and 5 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29738430/C19_Norditerpenoid_Alkaloids_from_Aconitum_szechenyianum_ L2 - https://www.mdpi.com/resolver?pii=molecules23051108 DB - PRIME DP - Unbound Medicine ER -