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The impact of nontraditional lipid profiles on left ventricular geometric abnormalities in general Chinese population.
BMC Cardiovasc Disord. 2018 05 08; 18(1):88.BC

Abstract

BACKGROUND

Despite current interest in the unfavorable impact of nontraditional lipid profiles on cardiovascular disease, information regarding its relations to abnormal left ventricular (LV) geometry has not been systemically elucidated. This study sought to understand predictive implication of nontraditional lipid profiles in specific LV geometric patterns in the general population of rural China.

METHODS

Analyses were based upon a cross-sectional study of 10,756 participants (mean age 53.8 years; 54.0% females) who underwent assessment of biochemical, anthropometric, and blood pressure variables in rural areas of China. Participants were classified into four groups of LV morphologic pattern according to left ventricular mass index (LVMI) and relative wall thickness with quantitative echocardiographic data.

RESULTS

By multivariable-adjusted linear regression models, nontraditional lipid profiles were positive determinants of concentricity index and LV wall thickness (all P < 0.05), with modest effects on LVMI. Non-high-density lipoprotein cholesterol (non-HDL-C) emerged as an independent correlate of concentric LV hypertrophy (LVH) (adjusted odds ratio [OR]: 1.174 per 1 SD increment in non-HDL-C, 95% confidence interval [CI]: 1.075-1.281), followed by low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (1.158 [1.059-1.266]), total cholesterol (TC)/HDL-C ratio (1.150 [1.050-1.260]), and triglyceride (TG)/HDL-C ratio (1.134 [1.030-1.249]). The ORs for concentric LVH by tertiles further provided insight into that excess risk was associated with the highest tertile of nontraditional lipid profiles. The areas under the ROC curves to predict concentric LVH were statistically identical among nontraditional lipid parameters.

CONCLUSION

Nontraditional lipid profiles, easily measured in the everyday routine examination, were responsible for increased risk of concentric LVH, potentially providing enhanced clinical utility at no additional cost, which emphasized the beneficial effect of these markers to supplement and improve CVD risk stratification.

Authors+Show Affiliations

Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. sunyingxian1962@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29739326

Citation

Wang, Haoyu, et al. "The Impact of Nontraditional Lipid Profiles On Left Ventricular Geometric Abnormalities in General Chinese Population." BMC Cardiovascular Disorders, vol. 18, no. 1, 2018, p. 88.
Wang H, Li Z, Guo X, et al. The impact of nontraditional lipid profiles on left ventricular geometric abnormalities in general Chinese population. BMC Cardiovasc Disord. 2018;18(1):88.
Wang, H., Li, Z., Guo, X., Chen, Y., Chang, Y., Chen, S., & Sun, Y. (2018). The impact of nontraditional lipid profiles on left ventricular geometric abnormalities in general Chinese population. BMC Cardiovascular Disorders, 18(1), 88. https://doi.org/10.1186/s12872-018-0829-x
Wang H, et al. The Impact of Nontraditional Lipid Profiles On Left Ventricular Geometric Abnormalities in General Chinese Population. BMC Cardiovasc Disord. 2018 05 8;18(1):88. PubMed PMID: 29739326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of nontraditional lipid profiles on left ventricular geometric abnormalities in general Chinese population. AU - Wang,Haoyu, AU - Li,Zhao, AU - Guo,Xiaofan, AU - Chen,Yintao, AU - Chang,Ye, AU - Chen,Shuang, AU - Sun,Yingxian, Y1 - 2018/05/08/ PY - 2018/01/08/received PY - 2018/05/03/accepted PY - 2018/5/10/entrez PY - 2018/5/10/pubmed PY - 2019/3/15/medline KW - General population KW - Left ventricular geometry KW - Left ventricular hypertrophy KW - Lipids KW - Nontraditional lipid profiles SP - 88 EP - 88 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 18 IS - 1 N2 - BACKGROUND: Despite current interest in the unfavorable impact of nontraditional lipid profiles on cardiovascular disease, information regarding its relations to abnormal left ventricular (LV) geometry has not been systemically elucidated. This study sought to understand predictive implication of nontraditional lipid profiles in specific LV geometric patterns in the general population of rural China. METHODS: Analyses were based upon a cross-sectional study of 10,756 participants (mean age 53.8 years; 54.0% females) who underwent assessment of biochemical, anthropometric, and blood pressure variables in rural areas of China. Participants were classified into four groups of LV morphologic pattern according to left ventricular mass index (LVMI) and relative wall thickness with quantitative echocardiographic data. RESULTS: By multivariable-adjusted linear regression models, nontraditional lipid profiles were positive determinants of concentricity index and LV wall thickness (all P < 0.05), with modest effects on LVMI. Non-high-density lipoprotein cholesterol (non-HDL-C) emerged as an independent correlate of concentric LV hypertrophy (LVH) (adjusted odds ratio [OR]: 1.174 per 1 SD increment in non-HDL-C, 95% confidence interval [CI]: 1.075-1.281), followed by low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (1.158 [1.059-1.266]), total cholesterol (TC)/HDL-C ratio (1.150 [1.050-1.260]), and triglyceride (TG)/HDL-C ratio (1.134 [1.030-1.249]). The ORs for concentric LVH by tertiles further provided insight into that excess risk was associated with the highest tertile of nontraditional lipid profiles. The areas under the ROC curves to predict concentric LVH were statistically identical among nontraditional lipid parameters. CONCLUSION: Nontraditional lipid profiles, easily measured in the everyday routine examination, were responsible for increased risk of concentric LVH, potentially providing enhanced clinical utility at no additional cost, which emphasized the beneficial effect of these markers to supplement and improve CVD risk stratification. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/29739326/The_impact_of_nontraditional_lipid_profiles_on_left_ventricular_geometric_abnormalities_in_general_Chinese_population_ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-018-0829-x DB - PRIME DP - Unbound Medicine ER -