Tags

Type your tag names separated by a space and hit enter

Long-lasting remission in a case of Cronkhite-Canada syndrome.
BMJ Case Rep. 2018 May 08; 2018BC

Abstract

Cronkhite-Canada syndrome is a rare disease characterised by diffuse gastrointestinal polyposis, diarrhoea, weight loss, skin hyperpigmentation, onychodystrophy and alopecia. More than 500 cases have been described in the medical literature so far. The disease is probably caused by immune-mediated inflammatory mechanisms, and the diagnosis is based on clinical history, physical examination, endoscopic findings and histology. Differentiating this condition from other clinical entities presenting with similar signs and symptoms may be challenging. We present here the case of a 70-year-old Sardinian man where apparently the syndrome was induced by a mental strain triggered by a work-related accident. Continuous treatment with low-dose of antidepressant, anti-inflammatory and immunosuppressive medications in addition to nutritional support was remarkably effective and resulted in sustained (longer than 8 years) disappearance of clinical manifestations as well as the persistence of physical and psychological well-being. This case argues against the poor prognosis previously ascribed to patients with this syndrome.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.Royal Free Unit for Endoscopy and Centre for Gastroenterology, The Royal Free Hospital, London, United Kingdom.Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29739761

Citation

Dore, Maria Pina, et al. "Long-lasting Remission in a Case of Cronkhite-Canada Syndrome." BMJ Case Reports, vol. 2018, 2018.
Dore MP, Satta R, Murino A, et al. Long-lasting remission in a case of Cronkhite-Canada syndrome. BMJ Case Rep. 2018;2018.
Dore, M. P., Satta, R., Murino, A., & Pes, G. M. (2018). Long-lasting remission in a case of Cronkhite-Canada syndrome. BMJ Case Reports, 2018. https://doi.org/10.1136/bcr-2017-223527
Dore MP, et al. Long-lasting Remission in a Case of Cronkhite-Canada Syndrome. BMJ Case Rep. 2018 May 8;2018 PubMed PMID: 29739761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-lasting remission in a case of Cronkhite-Canada syndrome. AU - Dore,Maria Pina, AU - Satta,Rosanna, AU - Murino,Alberto, AU - Pes,Giovanni Mario, Y1 - 2018/05/08/ PY - 2018/5/10/entrez PY - 2018/5/10/pubmed PY - 2018/10/4/medline KW - endoscopy KW - gastrointestinal system JF - BMJ case reports JO - BMJ Case Rep VL - 2018 N2 - Cronkhite-Canada syndrome is a rare disease characterised by diffuse gastrointestinal polyposis, diarrhoea, weight loss, skin hyperpigmentation, onychodystrophy and alopecia. More than 500 cases have been described in the medical literature so far. The disease is probably caused by immune-mediated inflammatory mechanisms, and the diagnosis is based on clinical history, physical examination, endoscopic findings and histology. Differentiating this condition from other clinical entities presenting with similar signs and symptoms may be challenging. We present here the case of a 70-year-old Sardinian man where apparently the syndrome was induced by a mental strain triggered by a work-related accident. Continuous treatment with low-dose of antidepressant, anti-inflammatory and immunosuppressive medications in addition to nutritional support was remarkably effective and resulted in sustained (longer than 8 years) disappearance of clinical manifestations as well as the persistence of physical and psychological well-being. This case argues against the poor prognosis previously ascribed to patients with this syndrome. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/29739761/Long_lasting_remission_in_a_case_of_Cronkhite_Canada_syndrome_ L2 - https://casereports.bmj.com/cgi/pmidlookup?view=long&pmid=29739761 DB - PRIME DP - Unbound Medicine ER -