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The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner.
Oxid Med Cell Longev 2018; 2018:7924021OM

Abstract

Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread gynecological diseases with a 10-15% prevalence in the general female population, rising up to 30-45% in patients with infertility. Although it was first described in 1860, its etiology and pathogenesis are still unclear. It is now accepted that inflammation plays a central role in the development and progression of endometriosis. In particular, it is marked by an inflammatory process associated with the overproduction of an array of inflammatory mediators such as prostaglandins, metalloproteinases, cytokines, and chemokines. In addition, the growth and adhesion of endometrial cells in the peritoneal cavity due to reactive oxygen species (ROS) and free radicals lead to disease onset, its ensuing symptoms-among which pain and infertility. The aim of our review is to evaluate the role of oxidative stress and ROS in the pathogenesis of endometriosis and the efficacy of antioxidant therapy in the treatment and mitigation of its symptoms.

Authors+Show Affiliations

Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.Department of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, Via Álvaro del Portillo 21, 00128 Rome, Italy.Department of Medicine, Surgery and Health Sciences, University of Trieste, Ospedale di Cattinara, Strada di Fiume 447, 34149 Trieste, Italy.Unit of Psychodiagnostics and Clinical Psychology, University of Catania, Via Santa Sofia 78, 95124 Catania, Italy.Department of Woman and Child Health, University of Padua, Via Giustiniani 3, 35128 Padua, Italy.Department of Woman and Child Health, University of Padua, Via Giustiniani 3, 35128 Padua, Italy.Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, 95124 Catania, Italy.Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, 95124 Catania, Italy.Department of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, Via Álvaro del Portillo 21, 00128 Rome, Italy.Department of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, Via Álvaro del Portillo 21, 00128 Rome, Italy.Department of General Surgery and Medical Surgical Specialties, University of Catania, Via Santa Sofia 78, 95124 Catania, Italy.Unit of Gynecology and Obstetrics, Desenzano del Garda Hospital, Section of Gavardo, Via A. Gosa 74, 25085 Gavardo, Italy.Department of Obstetrics and Gynecology, Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29743986

Citation

Vitale, Salvatore Giovanni, et al. "The Role of Oxidative Stress and Membrane Transport Systems During Endometriosis: a Fresh Look at a Busy Corner." Oxidative Medicine and Cellular Longevity, vol. 2018, 2018, p. 7924021.
Vitale SG, Capriglione S, Peterlunger I, et al. The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxid Med Cell Longev. 2018;2018:7924021.
Vitale, S. G., Capriglione, S., Peterlunger, I., La Rosa, V. L., Vitagliano, A., Noventa, M., ... Zito, G. (2018). The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxidative Medicine and Cellular Longevity, 2018, p. 7924021. doi:10.1155/2018/7924021.
Vitale SG, et al. The Role of Oxidative Stress and Membrane Transport Systems During Endometriosis: a Fresh Look at a Busy Corner. Oxid Med Cell Longev. 2018;2018:7924021. PubMed PMID: 29743986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. AU - Vitale,Salvatore Giovanni, AU - Capriglione,Stella, AU - Peterlunger,Isabel, AU - La Rosa,Valentina Lucia, AU - Vitagliano,Amerigo, AU - Noventa,Marco, AU - Valenti,Gaetano, AU - Sapia,Fabrizio, AU - Angioli,Roberto, AU - Lopez,Salvatore, AU - Sarpietro,Giuseppe, AU - Rossetti,Diego, AU - Zito,Gabriella, Y1 - 2018/03/21/ PY - 2017/08/17/received PY - 2018/02/18/accepted PY - 2018/5/11/entrez PY - 2018/5/11/pubmed PY - 2018/9/18/medline SP - 7924021 EP - 7924021 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2018 N2 - Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread gynecological diseases with a 10-15% prevalence in the general female population, rising up to 30-45% in patients with infertility. Although it was first described in 1860, its etiology and pathogenesis are still unclear. It is now accepted that inflammation plays a central role in the development and progression of endometriosis. In particular, it is marked by an inflammatory process associated with the overproduction of an array of inflammatory mediators such as prostaglandins, metalloproteinases, cytokines, and chemokines. In addition, the growth and adhesion of endometrial cells in the peritoneal cavity due to reactive oxygen species (ROS) and free radicals lead to disease onset, its ensuing symptoms-among which pain and infertility. The aim of our review is to evaluate the role of oxidative stress and ROS in the pathogenesis of endometriosis and the efficacy of antioxidant therapy in the treatment and mitigation of its symptoms. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/29743986/The_Role_of_Oxidative_Stress_and_Membrane_Transport_Systems_during_Endometriosis:_A_Fresh_Look_at_a_Busy_Corner_ L2 - https://dx.doi.org/10.1155/2018/7924021 DB - PRIME DP - Unbound Medicine ER -