Tags

Type your tag names separated by a space and hit enter

[Drugs for intravenous induction of anesthesia: barbiturates].
Anaesthesist. 2018 07; 67(7):535-552.A

Abstract

The discovery of barbituric acid and research on its derivatives have long been of importance in advancements in modern anesthesia. Decades of clinical use of barbiturates worldwide and their abuse has led to an enormous amount of knowledge. Thiopental and methohexital are ultra-short acting derivatives of barbiturates. Their clinical application has been accompanied by an enormous increase in the knowledge of the pharmacology of cerebrally active drugs, in particular gamma-aminobutyric acid (GABAA) receptor and GABA-induced effects on nerve cell membranes. Despite the development of newer substances, thiopental still has a firm place in clinical applications. Currently it is mainly used in obstetrics for induction of cesarean sections under general anesthesia. A disadvantage, when properly used to induce anesthesia, is usually only the prolonged elimination kinetics of barbiturates. It is beneficial that barbiturates do not require side effect provoking solubilizers.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Dumps C
Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland. christian.dumps@klinikum-augsburg.de.
Halbeck E
Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.
Bolkenius D
Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

MeSH

Anesthesia, IntravenousAnesthesia, ObstetricalBarbituratesCesarean SectionGABA-A Receptor AgonistsHumansMethohexitalReceptors, GABA-AThiopental

Pub Type(s)

Journal Article
Review

Language

ger

PubMed ID

29744526

Citation

Dumps, C, et al. "[Drugs for Intravenous Induction of Anesthesia: Barbiturates]." Der Anaesthesist, vol. 67, no. 7, 2018, pp. 535-552.
Dumps C, Halbeck E, Bolkenius D. [Drugs for intravenous induction of anesthesia: barbiturates]. Anaesthesist. 2018;67(7):535-552.
Dumps, C., Halbeck, E., & Bolkenius, D. (2018). [Drugs for intravenous induction of anesthesia: barbiturates]. Der Anaesthesist, 67(7), 535-552. https://doi.org/10.1007/s00101-018-0440-7
Dumps C, Halbeck E, Bolkenius D. [Drugs for Intravenous Induction of Anesthesia: Barbiturates]. Anaesthesist. 2018;67(7):535-552. PubMed PMID: 29744526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Drugs for intravenous induction of anesthesia: barbiturates]. AU - Dumps,C, AU - Halbeck,E, AU - Bolkenius,D, PY - 2018/5/11/pubmed PY - 2020/1/7/medline PY - 2018/5/11/entrez KW - Cesarean section KW - Methohexital KW - Pharmacodynamics KW - Pharmacokinetics KW - Thiopental SP - 535 EP - 552 JF - Der Anaesthesist JO - Anaesthesist VL - 67 IS - 7 N2 - The discovery of barbituric acid and research on its derivatives have long been of importance in advancements in modern anesthesia. Decades of clinical use of barbiturates worldwide and their abuse has led to an enormous amount of knowledge. Thiopental and methohexital are ultra-short acting derivatives of barbiturates. Their clinical application has been accompanied by an enormous increase in the knowledge of the pharmacology of cerebrally active drugs, in particular gamma-aminobutyric acid (GABAA) receptor and GABA-induced effects on nerve cell membranes. Despite the development of newer substances, thiopental still has a firm place in clinical applications. Currently it is mainly used in obstetrics for induction of cesarean sections under general anesthesia. A disadvantage, when properly used to induce anesthesia, is usually only the prolonged elimination kinetics of barbiturates. It is beneficial that barbiturates do not require side effect provoking solubilizers. SN - 1432-055X UR - https://www.unboundmedicine.com/medline/citation/29744526/[Drugs_for_intravenous_induction_of_anesthesia:_barbiturates]_ DB - PRIME DP - Unbound Medicine ER -