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Impact of serum 25-OH vitamin D level on lower urinary tract symptoms in men: a step towards reducing overactive bladder.
BJU Int. 2018 10; 122(4):667-672.BI

Abstract

OBJECTIVES

To evaluate the impact of serum vitamin D level on male lower urinary tract symptoms (LUTS).

PATIENTS AND METHODS

Men with LUTS who visited the outpatient clinic of the urology department at one of two hospitals between March 2014 and April 2017 were eligible for inclusion in the study. The impact of vitamin D on LUTS was evaluated using multivariate analysis to adjust for age, body mass index, prostate-specific antigen, testosterone, glycated haemoglobin, physical activity and prostate volume. To exclude the effect of seasons, we also analysed the impact during each season.

RESULTS

Vitamin D level was lowest in winter. According to the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS), the severity of LUTS peaked in winter. There were no seasonal differences between prostate volume, maximum urinary flow rate (Qmax) and post-void residual urine volume (PVR). For all patients, multivariate analysis showed that lower vitamin D level was significantly associated with higher total OABSS, whereas it was not associated with prostate volume, Qmax , PVR or total IPSS. In winter, lower vitamin D level was significantly associated with higher total OABSS based on multivariate analysis, whereas it was not during other seasons. In patients with vitamin D deficiency, the total OABSS significantly decreased after vitamin D replacement. The greatest improvement in total OABSS was associated with lower pre-treatment total OABSS and higher post-treatment vitamin D level.

CONCLUSIONS

Vitamin D deficiency in men with LUTS may play a role in aggravated overactive bladder (OAB) symptoms, especially in winter. Increasing vitamin D level in patients with vitamin D deficiency appears to alleviate OAB symptoms.

Authors+Show Affiliations

Department of Urology, Boramae Medical Centre, Seoul National University, Seoul, Korea.Department of Biostatistics, Boramae Medical Centre, Seoul National University, Seoul, Korea.Department of Urology, Dongguk University Ilsan Medical Centre, Goyang, Korea.Department of Endocrinology and Metabolism, Dongguk University Ilsan Medical Centre, Goyang, Korea.Department of Urology, Boramae Medical Centre, Seoul National University, Seoul, Korea.Department of Urology, Boramae Medical Centre, Seoul National University, Seoul, Korea.Department of Urology, Boramae Medical Centre, Seoul National University, Seoul, Korea.Department of Urology, Boramae Medical Centre, Seoul National University, Seoul, Korea.Department of Urology, Dongguk University Ilsan Medical Centre, Goyang, Korea.Department of Urology, Boramae Medical Centre, Seoul National University, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29745000

Citation

Yoo, Sangjun, et al. "Impact of Serum 25-OH Vitamin D Level On Lower Urinary Tract Symptoms in Men: a Step Towards Reducing Overactive Bladder." BJU International, vol. 122, no. 4, 2018, pp. 667-672.
Yoo S, Oh S, Kim HS, et al. Impact of serum 25-OH vitamin D level on lower urinary tract symptoms in men: a step towards reducing overactive bladder. BJU Int. 2018;122(4):667-672.
Yoo, S., Oh, S., Kim, H. S., Choi, H. S., Park, J., Cho, S. Y., Son, H., Jeong, H., Lee, H. W., & Cho, M. C. (2018). Impact of serum 25-OH vitamin D level on lower urinary tract symptoms in men: a step towards reducing overactive bladder. BJU International, 122(4), 667-672. https://doi.org/10.1111/bju.14387
Yoo S, et al. Impact of Serum 25-OH Vitamin D Level On Lower Urinary Tract Symptoms in Men: a Step Towards Reducing Overactive Bladder. BJU Int. 2018;122(4):667-672. PubMed PMID: 29745000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of serum 25-OH vitamin D level on lower urinary tract symptoms in men: a step towards reducing overactive bladder. AU - Yoo,Sangjun, AU - Oh,Sohee, AU - Kim,Hyung Suk, AU - Choi,Han Seok, AU - Park,Juhyun, AU - Cho,Sung Yong, AU - Son,Hwancheol, AU - Jeong,Hyeon, AU - Lee,Hae Won, AU - Cho,Min Chul, Y1 - 2018/05/31/ PY - 2018/5/11/pubmed PY - 2019/3/27/medline PY - 2018/5/11/entrez KW - overactive KW - prostatic hyperplasia KW - seasons KW - urinary bladder KW - vitamin D SP - 667 EP - 672 JF - BJU international JO - BJU Int VL - 122 IS - 4 N2 - OBJECTIVES: To evaluate the impact of serum vitamin D level on male lower urinary tract symptoms (LUTS). PATIENTS AND METHODS: Men with LUTS who visited the outpatient clinic of the urology department at one of two hospitals between March 2014 and April 2017 were eligible for inclusion in the study. The impact of vitamin D on LUTS was evaluated using multivariate analysis to adjust for age, body mass index, prostate-specific antigen, testosterone, glycated haemoglobin, physical activity and prostate volume. To exclude the effect of seasons, we also analysed the impact during each season. RESULTS: Vitamin D level was lowest in winter. According to the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS), the severity of LUTS peaked in winter. There were no seasonal differences between prostate volume, maximum urinary flow rate (Qmax) and post-void residual urine volume (PVR). For all patients, multivariate analysis showed that lower vitamin D level was significantly associated with higher total OABSS, whereas it was not associated with prostate volume, Qmax , PVR or total IPSS. In winter, lower vitamin D level was significantly associated with higher total OABSS based on multivariate analysis, whereas it was not during other seasons. In patients with vitamin D deficiency, the total OABSS significantly decreased after vitamin D replacement. The greatest improvement in total OABSS was associated with lower pre-treatment total OABSS and higher post-treatment vitamin D level. CONCLUSIONS: Vitamin D deficiency in men with LUTS may play a role in aggravated overactive bladder (OAB) symptoms, especially in winter. Increasing vitamin D level in patients with vitamin D deficiency appears to alleviate OAB symptoms. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/29745000/Impact_of_serum_25_OH_vitamin_D_level_on_lower_urinary_tract_symptoms_in_men:_a_step_towards_reducing_overactive_bladder_ L2 - https://doi.org/10.1111/bju.14387 DB - PRIME DP - Unbound Medicine ER -