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Orodispersible Films: A Systematic Patent Review.
Recent Pat Drug Deliv Formul. 2018; 12(2):110-120.RP

Abstract

BACKGROUND

Nowadays, Oral Film Technology (OFT) has gained much attention among all the oral drug delivery systems. Fast dissolving film, fast disintegrating film, and orodispersible film are some synonymous words for this dosage form. Without a need of liquid for administration, this dosage form dissolves in the mouth. Typically, fast dissolving film dissolves from 1 to 30 seconds.

OBJECTIVE

At the root of its originality, many researchers patented their work on the aspect of orodispersible films using different drugs, polymers, excipients and employing various methods of preparation. The review focuses on details related to orodispersible films and their patents from 1979-2017, collected from various sources like USPTO, Google patent, Espacenet, Intellectual Property India.

RESULTS

For the ease of discussion, collected patents are segregated on the basis of drugs, polymers, and method of preparation. It was found that many researchers are shifting towards fast dissolving films for better patient compliance, extended efficacy, high bioavailability, fast dissolution, and disintegration. With the help of polymers blend suitable for the drug release and improved method of preparation various parameters like tensile strength, thickness, and pH etc. can be controlled.

CONCLUSION

It was observed that judicial selection of polymers and polymers blends and methods of preparation are key parameters in the formulation of orodispersible film.

Authors+Show Affiliations

School of Pharmacy & Technology Management, SVKM`s NMIMS, Shirpur, Maharashtra, India.School of Pharmacy & Technology Management, SVKM`s NMIMS, Shirpur, Maharashtra, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29745346

Citation

Gijare, Chaitrali, and Ashwini Deshpande. "Orodispersible Films: a Systematic Patent Review." Recent Patents On Drug Delivery & Formulation, vol. 12, no. 2, 2018, pp. 110-120.
Gijare C, Deshpande A. Orodispersible Films: A Systematic Patent Review. Recent Pat Drug Deliv Formul. 2018;12(2):110-120.
Gijare, C., & Deshpande, A. (2018). Orodispersible Films: A Systematic Patent Review. Recent Patents On Drug Delivery & Formulation, 12(2), 110-120. https://doi.org/10.2174/1872211312666180509100216
Gijare C, Deshpande A. Orodispersible Films: a Systematic Patent Review. Recent Pat Drug Deliv Formul. 2018;12(2):110-120. PubMed PMID: 29745346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orodispersible Films: A Systematic Patent Review. AU - Gijare,Chaitrali, AU - Deshpande,Ashwini, PY - 2018/01/16/received PY - 2018/04/27/revised PY - 2018/04/29/accepted PY - 2018/5/11/pubmed PY - 2018/11/10/medline PY - 2018/5/11/entrez KW - Orodispersible films KW - efficacy KW - gelatin capsules KW - patents KW - patient compliance KW - polymers. SP - 110 EP - 120 JF - Recent patents on drug delivery & formulation JO - Recent Pat Drug Deliv Formul VL - 12 IS - 2 N2 - BACKGROUND: Nowadays, Oral Film Technology (OFT) has gained much attention among all the oral drug delivery systems. Fast dissolving film, fast disintegrating film, and orodispersible film are some synonymous words for this dosage form. Without a need of liquid for administration, this dosage form dissolves in the mouth. Typically, fast dissolving film dissolves from 1 to 30 seconds. OBJECTIVE: At the root of its originality, many researchers patented their work on the aspect of orodispersible films using different drugs, polymers, excipients and employing various methods of preparation. The review focuses on details related to orodispersible films and their patents from 1979-2017, collected from various sources like USPTO, Google patent, Espacenet, Intellectual Property India. RESULTS: For the ease of discussion, collected patents are segregated on the basis of drugs, polymers, and method of preparation. It was found that many researchers are shifting towards fast dissolving films for better patient compliance, extended efficacy, high bioavailability, fast dissolution, and disintegration. With the help of polymers blend suitable for the drug release and improved method of preparation various parameters like tensile strength, thickness, and pH etc. can be controlled. CONCLUSION: It was observed that judicial selection of polymers and polymers blends and methods of preparation are key parameters in the formulation of orodispersible film. SN - 2212-4039 UR - https://www.unboundmedicine.com/medline/citation/29745346/Orodispersible_Films:_A_Systematic_Patent_Review_ L2 - http://www.eurekaselect.com/161983/article DB - PRIME DP - Unbound Medicine ER -