Tags

Type your tag names separated by a space and hit enter

Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated from Nepeta cadmea: An Endemic Plant for Turkey.
J Food Sci. 2018 Jun; 83(6):1552-1559.JF

Abstract

Nepeta cadmea Boiss. is a species endemic to Turkey that belongs to the Nepeta genus. Several species of this genus are used in folk medicine. This study was designed to investigate the phenolic compounds, antioxidant, anthelmintic, and cytotoxic activities of various extracts (ethanol, methanol, acetone, and water) of N. cadmea. The antioxidant activities of these extracts were analyzed using scavenging methods (DPPH, ABTS, and H2 O2 scavenging activity), the β-carotene/linoleic acid test system, the phosphomolybdenum method, and metal chelating activity. Among the 4 different extracts of N. cadmea that were evaluated, the water extract showed the highest amount of radical scavenging (DPPH, 25.54 μg/mL and ABTS, 14.51 μg/mL) and antioxidant activities (β-carotene, 86.91%). In the metal chelating and H2 O2 scavenging activities, the acetone extract was statistically different from the other extracts. For the phosphomolybdenum method, the antioxidant capacity of the extracts was in the range of 8.15 to 80.40 μg/mg. The phenolic content of the ethanol extract was examined using HPLC and determined some phenolics: epicatechin, chlorogenic, and caffeic acids. With regard to the anthelmintic properties, dose-dependent activity was observed in each of the extracts of N. cadmea. All the extracts exhibited high cytotoxic activities. The results will provide additional information for further studies on the biological activities of N. cadmea, while also helping us to understand the importance of this species. Furthermore, based on the results obtained, N. cadmea may be considered as a potentially useful supplement for the human diet, as well as a natural antioxidant for medicinal applications.

PRACTICAL APPLICATION

The plants of the Nepeta genus have been extensively used as traditional herbal medicines. Nepeta cadmea Boiss., one of the species belonging to the Nepeta genus, is a species endemic to Turkey. In our study, we demonstrated the antioxidant capacities, total phenolic, flavonoid, tannin content, anthelmintic, and cytotoxic activities of various extracts of Nepeta cadmea. The present study could well supply valuable data for future investigations and further information on the potential use of this endemic plant for humans, in both dietary and pharmacological applications.

Authors+Show Affiliations

Dept. of Science and Mathematics, Faculty of Education, Pamukkale Univ., Denizli, Turkey.Dept. of Biology, Faculty of Arts and Science, Pamukkale Univ., Denizli, Turkey.Dept. of Biology, Faculty of Arts and Science, Pamukkale Univ., Denizli, Turkey.Dept. of Biology, Faculty of Arts and Science, Pamukkale Univ., Denizli, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29746001

Citation

Kaska, Arzu, et al. "Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated From Nepeta Cadmea: an Endemic Plant for Turkey." Journal of Food Science, vol. 83, no. 6, 2018, pp. 1552-1559.
Kaska A, Deniz N, Çiçek M, et al. Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated from Nepeta cadmea: An Endemic Plant for Turkey. J Food Sci. 2018;83(6):1552-1559.
Kaska, A., Deniz, N., Çiçek, M., & Mammadov, R. (2018). Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated from Nepeta cadmea: An Endemic Plant for Turkey. Journal of Food Science, 83(6), 1552-1559. https://doi.org/10.1111/1750-3841.14167
Kaska A, et al. Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated From Nepeta Cadmea: an Endemic Plant for Turkey. J Food Sci. 2018;83(6):1552-1559. PubMed PMID: 29746001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of Antioxidant Properties, Phenolic Compounds, Anthelmintic, and Cytotoxic Activities of Various Extracts Isolated from Nepeta cadmea: An Endemic Plant for Turkey. AU - Kaska,Arzu, AU - Deniz,Nahide, AU - Çiçek,Mehmet, AU - Mammadov,Ramazan, Y1 - 2018/05/10/ PY - 2017/10/01/received PY - 2018/03/04/revised PY - 2018/03/29/accepted PY - 2018/5/11/pubmed PY - 2018/10/5/medline PY - 2018/5/11/entrez KW - HPLC KW - Nepeta cadmea KW - biological activities KW - medicinal plant KW - phenolic content SP - 1552 EP - 1559 JF - Journal of food science JO - J. Food Sci. VL - 83 IS - 6 N2 - : Nepeta cadmea Boiss. is a species endemic to Turkey that belongs to the Nepeta genus. Several species of this genus are used in folk medicine. This study was designed to investigate the phenolic compounds, antioxidant, anthelmintic, and cytotoxic activities of various extracts (ethanol, methanol, acetone, and water) of N. cadmea. The antioxidant activities of these extracts were analyzed using scavenging methods (DPPH, ABTS, and H2 O2 scavenging activity), the β-carotene/linoleic acid test system, the phosphomolybdenum method, and metal chelating activity. Among the 4 different extracts of N. cadmea that were evaluated, the water extract showed the highest amount of radical scavenging (DPPH, 25.54 μg/mL and ABTS, 14.51 μg/mL) and antioxidant activities (β-carotene, 86.91%). In the metal chelating and H2 O2 scavenging activities, the acetone extract was statistically different from the other extracts. For the phosphomolybdenum method, the antioxidant capacity of the extracts was in the range of 8.15 to 80.40 μg/mg. The phenolic content of the ethanol extract was examined using HPLC and determined some phenolics: epicatechin, chlorogenic, and caffeic acids. With regard to the anthelmintic properties, dose-dependent activity was observed in each of the extracts of N. cadmea. All the extracts exhibited high cytotoxic activities. The results will provide additional information for further studies on the biological activities of N. cadmea, while also helping us to understand the importance of this species. Furthermore, based on the results obtained, N. cadmea may be considered as a potentially useful supplement for the human diet, as well as a natural antioxidant for medicinal applications. PRACTICAL APPLICATION: The plants of the Nepeta genus have been extensively used as traditional herbal medicines. Nepeta cadmea Boiss., one of the species belonging to the Nepeta genus, is a species endemic to Turkey. In our study, we demonstrated the antioxidant capacities, total phenolic, flavonoid, tannin content, anthelmintic, and cytotoxic activities of various extracts of Nepeta cadmea. The present study could well supply valuable data for future investigations and further information on the potential use of this endemic plant for humans, in both dietary and pharmacological applications. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/29746001/Evaluation_of_Antioxidant_Properties_Phenolic_Compounds_Anthelmintic_and_Cytotoxic_Activities_of_Various_Extracts_Isolated_from_Nepeta_cadmea:_An_Endemic_Plant_for_Turkey_ L2 - https://doi.org/10.1111/1750-3841.14167 DB - PRIME DP - Unbound Medicine ER -