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Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study.
Eur Respir J. 2018 06; 51(6)ER

Abstract

We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93-1.06) per allele score. A 25 nmol·L-1 increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54-1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.

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Authors+Show Affiliations

Sun YQ
Dept of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Brumpton BM
K.G. Jebsen Center for Genetic Epidemiology, Dept of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. Dept of Thoracic Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Bonilla C
MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Lewis SJ
MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Burgess S
MRC Biostatistics Unit, University of Cambridge, Cambridge, UK. Cardiovascular Epidemiology Unit, Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Skorpen F
Dept of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Chen Y
School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Nilsen TIL
Dept of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. Clinic of Anesthesia and Intensive Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Romundstad PR
Dept of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Mai XM
Dept of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

MeSH

AdultAgedAllelesFemaleGenetic Predisposition to DiseaseHumansIncidenceLinear ModelsLung NeoplasmsMaleMendelian Randomization AnalysisMiddle AgedNorwayPolymorphism, Single NucleotideProspective StudiesRegistriesVitamin D

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29748306

Citation

Sun, Yi-Qian, et al. "Serum 25-hydroxyvitamin D Levels and Risk of Lung Cancer and Histologic Types: a Mendelian Randomisation Analysis of the HUNT Study." The European Respiratory Journal, vol. 51, no. 6, 2018.
Sun YQ, Brumpton BM, Bonilla C, et al. Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study. Eur Respir J. 2018;51(6).
Sun, Y. Q., Brumpton, B. M., Bonilla, C., Lewis, S. J., Burgess, S., Skorpen, F., Chen, Y., Nilsen, T. I. L., Romundstad, P. R., & Mai, X. M. (2018). Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study. The European Respiratory Journal, 51(6). https://doi.org/10.1183/13993003.00329-2018
Sun YQ, et al. Serum 25-hydroxyvitamin D Levels and Risk of Lung Cancer and Histologic Types: a Mendelian Randomisation Analysis of the HUNT Study. Eur Respir J. 2018;51(6) PubMed PMID: 29748306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study. AU - Sun,Yi-Qian, AU - Brumpton,Ben M, AU - Bonilla,Carolina, AU - Lewis,Sarah J, AU - Burgess,Stephen, AU - Skorpen,Frank, AU - Chen,Yue, AU - Nilsen,Tom I L, AU - Romundstad,Pål Richard, AU - Mai,Xiao-Mei, Y1 - 2018/06/07/ PY - 2018/02/14/received PY - 2018/04/22/accepted PY - 2018/5/12/pubmed PY - 2019/6/6/medline PY - 2018/5/12/entrez JF - The European respiratory journal JO - Eur Respir J VL - 51 IS - 6 N2 - We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93-1.06) per allele score. A 25 nmol·L-1 increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54-1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/29748306/Serum_25_hydroxyvitamin_D_levels_and_risk_of_lung_cancer_and_histologic_types:_a_Mendelian_randomisation_analysis_of_the_HUNT_study_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=29748306 DB - PRIME DP - Unbound Medicine ER -