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Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children.
J Clin Endocrinol Metab. 2018 07 01; 103(7):2670-2679.JC

Abstract

Context

The associations of serum 25-hydroxyvitamin D [25(OH)D] with plasma lipids remain controversial in children.

Objective

To examine the associations and interactions of 25(OH)D and related gene variants with lipids in children.

Design

Cross-sectional.

Setting

Kuopio, Finland.

Participants

Population sample of 419 prepubertal white children aged 6 to 8 years.

Main Outcome Measures

25(OH)D, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides.

Results

Serum 25(OH)D was negatively associated with total cholesterol (β = -0.141, P = 0.004), LDL cholesterol (β = -0.112, P = 0.023), HDL cholesterol (β = -0.150, P = 0.002), and triglycerides (β = -0.104, P = 0.035) adjusted for age and sex. Associations of 25(OH)D with total cholesterol, LDL cholesterol, and HDL cholesterol remained after adjustment for adiposity, physical activity, sedentary behavior, diet, daylight time, and parental education. Children in the highest quartile of 25(OH)D had the lowest total cholesterol (P = 0.022) and LDL cholesterol (P = 0.026) adjusted for age and sex. Cytochrome P450 family 2 subfamily R member 1 (CYP2R1) rs12794714, CYP2R1 rs10741657, and vitamin D binding protein (DBP) rs2282679 were associated with 25(OH)D adjusted for age and sex. CYP2R1 rs12794714 was associated with total cholesterol and LDL cholesterol and C10orf88 rs6599638 with HDL cholesterol adjusted for age, sex, and 25(OH)D. The gene variants did not explain or modify the associations of 25(OH)D with lipids.

Conclusions

25(OH)D was independently and inversely associated with total cholesterol, LDL cholesterol, and HDL cholesterol. CYP2R1 rs12794714, CYP2R1 rs10741657, and DBP rs2282679 were associated with 25(OH)D. CYP2R1 rs12794714 was associated with total cholesterol and LDL cholesterol and chromosome 10 open reading frame 88 (C10orf88) rs6599638 with HDL cholesterol independent of 25(OH)D. None of the gene variants modified the associations of 25(OH)D with lipids. Further studies are needed to detect the mechanisms for the associations of 25(OH)D with lipids.

Authors+Show Affiliations

Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. Social and Health Center, City of Varkaus, Varkaus, Finland.Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. Department of Adolescent Psychiatry, Kuopio University Hospital, Kuopio, Finland. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland.Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland.Department of Pediatrics, North Karelia Central Hospital, Joensuu, Finland.Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. University of Eastern Finland Library Kuopio, Kuopio, Finland.Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29750416

Citation

Soininen, Sonja, et al. "Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children." The Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 7, 2018, pp. 2670-2679.
Soininen S, Eloranta AM, Viitasalo A, et al. Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children. J Clin Endocrinol Metab. 2018;103(7):2670-2679.
Soininen, S., Eloranta, A. M., Viitasalo, A., Dion, G., Erkkilä, A., Sidoroff, V., Lindi, V., Mahonen, A., & Lakka, T. A. (2018). Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children. The Journal of Clinical Endocrinology and Metabolism, 103(7), 2670-2679. https://doi.org/10.1210/jc.2018-00335
Soininen S, et al. Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children. J Clin Endocrinol Metab. 2018 07 1;103(7):2670-2679. PubMed PMID: 29750416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-Hydroxyvitamin D, Plasma Lipids, and Associated Gene Variants in Prepubertal Children. AU - Soininen,Sonja, AU - Eloranta,Aino-Maija, AU - Viitasalo,Anna, AU - Dion,Geneviève, AU - Erkkilä,Arja, AU - Sidoroff,Virpi, AU - Lindi,Virpi, AU - Mahonen,Anitta, AU - Lakka,Timo A, PY - 2018/02/10/received PY - 2018/05/04/accepted PY - 2018/5/12/pubmed PY - 2019/1/5/medline PY - 2018/5/12/entrez SP - 2670 EP - 2679 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 103 IS - 7 N2 - Context: The associations of serum 25-hydroxyvitamin D [25(OH)D] with plasma lipids remain controversial in children. Objective: To examine the associations and interactions of 25(OH)D and related gene variants with lipids in children. Design: Cross-sectional. Setting: Kuopio, Finland. Participants: Population sample of 419 prepubertal white children aged 6 to 8 years. Main Outcome Measures: 25(OH)D, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. Results: Serum 25(OH)D was negatively associated with total cholesterol (β = -0.141, P = 0.004), LDL cholesterol (β = -0.112, P = 0.023), HDL cholesterol (β = -0.150, P = 0.002), and triglycerides (β = -0.104, P = 0.035) adjusted for age and sex. Associations of 25(OH)D with total cholesterol, LDL cholesterol, and HDL cholesterol remained after adjustment for adiposity, physical activity, sedentary behavior, diet, daylight time, and parental education. Children in the highest quartile of 25(OH)D had the lowest total cholesterol (P = 0.022) and LDL cholesterol (P = 0.026) adjusted for age and sex. Cytochrome P450 family 2 subfamily R member 1 (CYP2R1) rs12794714, CYP2R1 rs10741657, and vitamin D binding protein (DBP) rs2282679 were associated with 25(OH)D adjusted for age and sex. CYP2R1 rs12794714 was associated with total cholesterol and LDL cholesterol and C10orf88 rs6599638 with HDL cholesterol adjusted for age, sex, and 25(OH)D. The gene variants did not explain or modify the associations of 25(OH)D with lipids. Conclusions: 25(OH)D was independently and inversely associated with total cholesterol, LDL cholesterol, and HDL cholesterol. CYP2R1 rs12794714, CYP2R1 rs10741657, and DBP rs2282679 were associated with 25(OH)D. CYP2R1 rs12794714 was associated with total cholesterol and LDL cholesterol and chromosome 10 open reading frame 88 (C10orf88) rs6599638 with HDL cholesterol independent of 25(OH)D. None of the gene variants modified the associations of 25(OH)D with lipids. Further studies are needed to detect the mechanisms for the associations of 25(OH)D with lipids. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/29750416/Serum_25_Hydroxyvitamin_D_Plasma_Lipids_and_Associated_Gene_Variants_in_Prepubertal_Children_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2018-00335 DB - PRIME DP - Unbound Medicine ER -