TY - JOUR T1 - Xanthones Content in Swertia multicaulis D. Don from Nepal. AU - Timsina,Binu, AU - Kindlmann,Pavel, AU - Rokaya,Maan B, AU - Vrchotová,Naděžda, AU - Tříska,Jan, AU - Horník,Štěpán, AU - Sýkora,Jan, Y1 - 2018/05/03/ PY - 2018/04/10/received PY - 2018/04/23/revised PY - 2018/05/01/accepted PY - 2018/5/13/entrez PY - 2018/5/13/pubmed PY - 2018/9/27/medline KW - Gentianaceae KW - HPLC KW - LC–MS KW - NMR KW - Swertia KW - phytochemistry KW - secondary metabolites JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 5 N2 - The medicinal plant Swertia multicaulis D. Don was collected in Rasuwa District (Nepal) and the xanthone content of its ethyl acetate extracts was studied. The total amount of xanthones in S. multicaulis determined by HPLC reaches almost 13 g of xanthones per 1 kg of dry matter. The identification of xanthones in S. multicaulis was achieved by a combination of HPLC, LC⁻MS and LC⁻NMR. The final assignment of the individual chemical structures was provided by NMR, supported by preparative HPLC. In eight chromatographic peaks, four major xanthones were identified—1,3-dihydroxy-5,8-dimethoxyxanthone, 1-hydroxy-3,5,8-trimethoxyxanthone, bellidifolin (1,5,8-tri-hydroxy-3-methoxyxanthone), and decussatin (1-hydroxy-3,7,8-trimethoxyxanthone). SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/29751500/Xanthones_Content_in_Swertia_multicaulis_D__Don_from_Nepal_ DB - PRIME DP - Unbound Medicine ER -