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Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation.
Nutrients 2018; 10(5)N

Abstract

Publications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharmacological agent, and give scant consideration of it being a nutrient. This limits their potential to detect beneficial effects in participants with vitamin D deficiency. An increasing body of evidence from both observational studies and clinical trials supports the presence of thresholds in vitamin D status below which disease risk increases and vitamin supplementation has beneficial effects. Future supplementation trials which seek to replicate these findings should recruit sufficient numbers of participants with low vitamin D levels, and not give low-dose vitamin D to the placebo group. If the presence of vitamin D thresholds for beneficial effects is confirmed, this would strengthen the need for vitamin D fortification of foods.

Authors+Show Affiliations

School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. r.scragg@auckland.ac.nz.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29751504

Citation

Scragg, Robert. "Emerging Evidence of Thresholds for Beneficial Effects From Vitamin D Supplementation." Nutrients, vol. 10, no. 5, 2018.
Scragg R. Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation. Nutrients. 2018;10(5).
Scragg, R. (2018). Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation. Nutrients, 10(5), doi:10.3390/nu10050561.
Scragg R. Emerging Evidence of Thresholds for Beneficial Effects From Vitamin D Supplementation. Nutrients. 2018 May 3;10(5) PubMed PMID: 29751504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation. A1 - Scragg,Robert, Y1 - 2018/05/03/ PY - 2018/03/15/received PY - 2018/04/29/revised PY - 2018/04/30/accepted PY - 2018/5/13/entrez PY - 2018/5/13/pubmed PY - 2018/11/20/medline KW - dose–response KW - randomized controlled trials KW - thresholds KW - vitamin D supplementation JF - Nutrients JO - Nutrients VL - 10 IS - 5 N2 - Publications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharmacological agent, and give scant consideration of it being a nutrient. This limits their potential to detect beneficial effects in participants with vitamin D deficiency. An increasing body of evidence from both observational studies and clinical trials supports the presence of thresholds in vitamin D status below which disease risk increases and vitamin supplementation has beneficial effects. Future supplementation trials which seek to replicate these findings should recruit sufficient numbers of participants with low vitamin D levels, and not give low-dose vitamin D to the placebo group. If the presence of vitamin D thresholds for beneficial effects is confirmed, this would strengthen the need for vitamin D fortification of foods. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29751504/Emerging_Evidence_of_Thresholds_for_Beneficial_Effects_from_Vitamin_D_Supplementation_ L2 - http://www.mdpi.com/resolver?pii=nu10050561 DB - PRIME DP - Unbound Medicine ER -