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Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children <5 years of age, Ghana, 2009-2016.
Vaccine. 2018 11 12; 36(47):7131-7134.V

Abstract

INTRODUCTION

Ghana introduced monovalent rotavirus vaccine in April 2012. We sought to determine the long-term impact of routine rotavirus vaccination on rotavirus gastroenteritis hospitalizations in Ghana during the first 4 years following rotavirus vaccine introduction.

METHODS

Active sentinel surveillance for acute gastroenteritis hospitalizations among children <5 years of age was conducted at two sites from July 2009 through June 2016. Stool specimens were collected from enrolled children and tested by enzyme immunoassay. Changes in the proportion of all-cause gastroenteritis hospitalizations due to rotavirus pre- (July 2009-June 2012) and post-vaccine introduction (July 2012-June 2016) were compared using chi-square test.

RESULTS

The proportion of acute gastroenteritis hospitalizations due to rotavirus among children <5 years of age significantly declined by 42% from a pre-vaccine median of 50% (343/684) to a post-vaccine median of 29% (118/396) (p < 0.001). The age distribution of rotavirus hospitalizations shifted toward older ages with 64% (759/1197) of rotavirus hospitalizations occurring in children <12 months of age pre-vaccine introduction to 47% (212/453) occurring in children <12 months of age post-vaccine introduction (p < 0.001).

DISCUSSION

The decline in rotavirus hospitalizations following rotavirus vaccine introduction have been sustained over the first 4 years of the vaccination program in Ghana. Continued vaccination against rotavirus will ensure that this burden remains low.

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Authors+Show Affiliations

Enweronu-Laryea CC
University of Ghana School of Medicine and Dentistry, Accra, Ghana. Electronic address: ccelaryea@ug.edu.gh.
Armah G
Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Sagoe KW
School of Basic and Allied Health Sciences, University of Ghana, Ghana.
Ansong D
School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Addo-Yobo E
School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Diamenu SK
World Health Organization Country Office, Accra, Ghana.
Mwenda JM
World Health Organization Regional Office for Africa, Brazzaville, Congo.
Parashar UD
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Tate JE
Centers for Disease Control and Prevention, Atlanta, GA, USA.

MeSH

Acute DiseaseAge DistributionChild, PreschoolFecesGastroenteritisGhanaHospitalizationHumansImmunization ProgramsImmunoenzyme TechniquesInfantRotavirusRotavirus InfectionsRotavirus VaccinesSentinel Surveillance

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

29752020

Citation

Enweronu-Laryea, Christabel C., et al. "Sustained Impact of Rotavirus Vaccine Introduction On Rotavirus Gastroenteritis Hospitalizations in Children <5 Years of Age, Ghana, 2009-2016." Vaccine, vol. 36, no. 47, 2018, pp. 7131-7134.
Enweronu-Laryea CC, Armah G, Sagoe KW, et al. Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children <5 years of age, Ghana, 2009-2016. Vaccine. 2018;36(47):7131-7134.
Enweronu-Laryea, C. C., Armah, G., Sagoe, K. W., Ansong, D., Addo-Yobo, E., Diamenu, S. K., Mwenda, J. M., Parashar, U. D., & Tate, J. E. (2018). Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children <5 years of age, Ghana, 2009-2016. Vaccine, 36(47), 7131-7134. https://doi.org/10.1016/j.vaccine.2018.02.058
Enweronu-Laryea CC, et al. Sustained Impact of Rotavirus Vaccine Introduction On Rotavirus Gastroenteritis Hospitalizations in Children <5 Years of Age, Ghana, 2009-2016. Vaccine. 2018 11 12;36(47):7131-7134. PubMed PMID: 29752020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children <5 years of age, Ghana, 2009-2016. AU - Enweronu-Laryea,Christabel C, AU - Armah,George, AU - Sagoe,Kwamena W, AU - Ansong,Daniel, AU - Addo-Yobo,Emmanuel, AU - Diamenu,Stanley K, AU - Mwenda,Jason M, AU - Parashar,Umesh D, AU - Tate,Jacqueline E, Y1 - 2018/05/08/ PY - 2018/01/17/received PY - 2018/02/07/revised PY - 2018/02/15/accepted PY - 2018/5/13/pubmed PY - 2019/2/15/medline PY - 2018/5/13/entrez KW - Ghana KW - Rotavirus KW - Rotavirus vaccine SP - 7131 EP - 7134 JF - Vaccine JO - Vaccine VL - 36 IS - 47 N2 - INTRODUCTION: Ghana introduced monovalent rotavirus vaccine in April 2012. We sought to determine the long-term impact of routine rotavirus vaccination on rotavirus gastroenteritis hospitalizations in Ghana during the first 4 years following rotavirus vaccine introduction. METHODS: Active sentinel surveillance for acute gastroenteritis hospitalizations among children <5 years of age was conducted at two sites from July 2009 through June 2016. Stool specimens were collected from enrolled children and tested by enzyme immunoassay. Changes in the proportion of all-cause gastroenteritis hospitalizations due to rotavirus pre- (July 2009-June 2012) and post-vaccine introduction (July 2012-June 2016) were compared using chi-square test. RESULTS: The proportion of acute gastroenteritis hospitalizations due to rotavirus among children <5 years of age significantly declined by 42% from a pre-vaccine median of 50% (343/684) to a post-vaccine median of 29% (118/396) (p < 0.001). The age distribution of rotavirus hospitalizations shifted toward older ages with 64% (759/1197) of rotavirus hospitalizations occurring in children <12 months of age pre-vaccine introduction to 47% (212/453) occurring in children <12 months of age post-vaccine introduction (p < 0.001). DISCUSSION: The decline in rotavirus hospitalizations following rotavirus vaccine introduction have been sustained over the first 4 years of the vaccination program in Ghana. Continued vaccination against rotavirus will ensure that this burden remains low. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/29752020/Sustained_impact_of_rotavirus_vaccine_introduction_on_rotavirus_gastroenteritis_hospitalizations_in_children_<5_years_of_age_Ghana_2009_2016_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(18)30245-7 DB - PRIME DP - Unbound Medicine ER -