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Cocaine impairs serial-feature negative learning and blood-brain barrier integrity.

Abstract

Previous research has shown that diets high in fat and sugar [a.k.a., Western diets (WD)] can impair performance of rats on hippocampal-dependent learning and memory problems, an effect that is accompanied by selective increases in hippocampal blood brain barrier (BBB) permeability. Based on these types of findings, it has been proposed that overeating of a WD (and its resulting obesity) may be, in part, a consequence of impairments in these anatomical substrates and cognitive processes. Given that drug use (and addiction) represents another behavioral excess, the present experiments assessed if similar outcomes might occur with drug exposure by evaluating the effects of cocaine administration on hippocampal-dependent memory and on the integrity of the BBB. Experiment 1 of the present series of studies found that systemic cocaine administration in rats also appears to have disruptive effects on the same hippocampal-dependent learning and memory mechanism that has been proposed to underlie the inhibition of food intake. Experiment 2 demonstrated that the same regimen of cocaine exposure that produced disruptions in learning and memory in Experiment 1 also produced increased BBB permeability in the hippocampus, but not in the striatum. Although the predominant focus of previous research investigating the etiologies of substance use and abuse has been on the brain circuits that underlie the motivational properties of drugs, the current investigation implicates the possible involvement of hippocampal memory systems in such behaviors. It is important to note that these positions are not mutually exclusive and that neuroadaptations in these two circuits might occur in parallel that generate dysregulated drug use in a manner similar to that of excessive eating.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States. Electronic address: terryd@american.edu.

    ,

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States.

    ,

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States.

    ,

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States.

    ,

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States.

    ,

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States.

    ,

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States.

    Center for Behavioral Neuroscience, Department of Psychology, American University, Washington, DC 20016, United States. Electronic address: alriley@american.edu.

    Source

    MeSH

    Animals
    Blood-Brain Barrier
    Cocaine
    Discrimination Learning
    Hippocampus
    Learning
    Male
    Memory
    Permeability
    Rats
    Rats, Sprague-Dawley

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    29753886

    Citation

    Davidson, Terry L., et al. "Cocaine Impairs Serial-feature Negative Learning and Blood-brain Barrier Integrity." Pharmacology, Biochemistry, and Behavior, vol. 170, 2018, pp. 56-63.
    Davidson TL, Hargrave SL, Kearns DN, et al. Cocaine impairs serial-feature negative learning and blood-brain barrier integrity. Pharmacol Biochem Behav. 2018;170:56-63.
    Davidson, T. L., Hargrave, S. L., Kearns, D. N., Clasen, M. M., Jones, S., Wakeford, A. G. P., ... Riley, A. L. (2018). Cocaine impairs serial-feature negative learning and blood-brain barrier integrity. Pharmacology, Biochemistry, and Behavior, 170, pp. 56-63. doi:10.1016/j.pbb.2018.05.005.
    Davidson TL, et al. Cocaine Impairs Serial-feature Negative Learning and Blood-brain Barrier Integrity. Pharmacol Biochem Behav. 2018;170:56-63. PubMed PMID: 29753886.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cocaine impairs serial-feature negative learning and blood-brain barrier integrity. AU - Davidson,Terry L, AU - Hargrave,Sara L, AU - Kearns,David N, AU - Clasen,Matthew M, AU - Jones,Sabrina, AU - Wakeford,Alison G P, AU - Sample,Camille H, AU - Riley,Anthony L, Y1 - 2018/05/10/ PY - 2018/02/12/received PY - 2018/05/07/revised PY - 2018/05/09/accepted PY - 2018/5/14/pubmed PY - 2019/3/23/medline PY - 2018/5/14/entrez KW - Blood brain barrier KW - Cocaine, hippocampal-dependent memory KW - Western diet SP - 56 EP - 63 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 170 N2 - Previous research has shown that diets high in fat and sugar [a.k.a., Western diets (WD)] can impair performance of rats on hippocampal-dependent learning and memory problems, an effect that is accompanied by selective increases in hippocampal blood brain barrier (BBB) permeability. Based on these types of findings, it has been proposed that overeating of a WD (and its resulting obesity) may be, in part, a consequence of impairments in these anatomical substrates and cognitive processes. Given that drug use (and addiction) represents another behavioral excess, the present experiments assessed if similar outcomes might occur with drug exposure by evaluating the effects of cocaine administration on hippocampal-dependent memory and on the integrity of the BBB. Experiment 1 of the present series of studies found that systemic cocaine administration in rats also appears to have disruptive effects on the same hippocampal-dependent learning and memory mechanism that has been proposed to underlie the inhibition of food intake. Experiment 2 demonstrated that the same regimen of cocaine exposure that produced disruptions in learning and memory in Experiment 1 also produced increased BBB permeability in the hippocampus, but not in the striatum. Although the predominant focus of previous research investigating the etiologies of substance use and abuse has been on the brain circuits that underlie the motivational properties of drugs, the current investigation implicates the possible involvement of hippocampal memory systems in such behaviors. It is important to note that these positions are not mutually exclusive and that neuroadaptations in these two circuits might occur in parallel that generate dysregulated drug use in a manner similar to that of excessive eating. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/29753886/Cocaine_impairs_serial_feature_negative_learning_and_blood_brain_barrier_integrity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(18)30076-5 DB - PRIME DP - Unbound Medicine ER -