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A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma.

Abstract

Circulating saturated (SFA) and monounsaturated fatty acids (MUFA), which are predominantly derived from endogenous metabolism, may influence non-Hodgkin lymphoma (NHL) risk by modulating inflammation or lymphocyte membrane stability. However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre-diagnosis red blood cell (RBC) specimens in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T-NHL), B cell NHL (B-NHL) and three individual B-NHLs: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B-NHLs other than CLL/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70, 0.95) for 20:0, 0.82 (0.70, 0.95) for 22:0 and 0.82 (0.70, 0.96) for 23:0 VLCSFA. Also, both VLCSFA and MUFA levels were inversely associated with T-NHL [ORs (95% CIs) per SD: VLCSFA, 0.63 (0.40, 0.99); MUFA, 0.63 (0.40, 0.99)]. The findings of inverse associations for VLCSFAs with B-NHLs other than CLL/SLL and for VLCSFA and MUFA with T-NHL suggest an influence of fatty acid metabolism on lymphomagenesis.

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  • Authors+Show Affiliations

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    Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

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    Slone Epidemiology Center, Boston University, Boston, MA.

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    Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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    Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

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    Department of Medicine and the Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA.

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    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.

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    Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA. AbbVie Pharmaceuticals, North Chicago, IL.

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    Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA. Centro de Investigación e Innovación en Nutrición Translacional y Salud, Universidad Hispanoamericana, San José, Costa Rica.

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    Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

    ,

    Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

    Source

    International journal of cancer 143:8 2018 10 15 pg 1914-1922

    MeSH

    Aged
    Fatty Acids
    Fatty Acids, Monounsaturated
    Female
    Follow-Up Studies
    Humans
    Logistic Models
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Odds Ratio
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    29756258

    Citation

    Chiu, Yu-Han, et al. "A Prospective Analysis of Circulating Saturated and Monounsaturated Fatty Acids and Risk of non-Hodgkin Lymphoma." International Journal of Cancer, vol. 143, no. 8, 2018, pp. 1914-1922.
    Chiu YH, Bertrand KA, Zhang S, et al. A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma. Int J Cancer. 2018;143(8):1914-1922.
    Chiu, Y. H., Bertrand, K. A., Zhang, S., Laden, F., Epstein, M. M., Rosner, B. A., ... Birmann, B. M. (2018). A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma. International Journal of Cancer, 143(8), pp. 1914-1922. doi:10.1002/ijc.31602.
    Chiu YH, et al. A Prospective Analysis of Circulating Saturated and Monounsaturated Fatty Acids and Risk of non-Hodgkin Lymphoma. Int J Cancer. 2018 10 15;143(8):1914-1922. PubMed PMID: 29756258.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma. AU - Chiu,Yu-Han, AU - Bertrand,Kimberly A, AU - Zhang,Shumin, AU - Laden,Francine, AU - Epstein,Mara M, AU - Rosner,Bernard A, AU - Chiuve,Stephanie, AU - Campos,Hannia, AU - Giovannucci,Edward L, AU - Chavarro,Jorge E, AU - Birmann,Brenda M, Y1 - 2018/08/10/ PY - 2017/10/29/received PY - 2018/04/09/revised PY - 2018/04/27/accepted PY - 2019/10/15/pmc-release PY - 2018/5/15/pubmed PY - 2019/1/27/medline PY - 2018/5/15/entrez KW - de novo lipogenesis KW - erythrocyte KW - fatty acids KW - non-Hodgkin lymphoma SP - 1914 EP - 1922 JF - International journal of cancer JO - Int. J. Cancer VL - 143 IS - 8 N2 - Circulating saturated (SFA) and monounsaturated fatty acids (MUFA), which are predominantly derived from endogenous metabolism, may influence non-Hodgkin lymphoma (NHL) risk by modulating inflammation or lymphocyte membrane stability. However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre-diagnosis red blood cell (RBC) specimens in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T-NHL), B cell NHL (B-NHL) and three individual B-NHLs: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B-NHLs other than CLL/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70, 0.95) for 20:0, 0.82 (0.70, 0.95) for 22:0 and 0.82 (0.70, 0.96) for 23:0 VLCSFA. Also, both VLCSFA and MUFA levels were inversely associated with T-NHL [ORs (95% CIs) per SD: VLCSFA, 0.63 (0.40, 0.99); MUFA, 0.63 (0.40, 0.99)]. The findings of inverse associations for VLCSFAs with B-NHLs other than CLL/SLL and for VLCSFA and MUFA with T-NHL suggest an influence of fatty acid metabolism on lymphomagenesis. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/29756258/A_prospective_analysis_of_circulating_saturated_and_monounsaturated_fatty_acids_and_risk_of_non_Hodgkin_lymphoma_ L2 - https://doi.org/10.1002/ijc.31602 DB - PRIME DP - Unbound Medicine ER -