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Magnesium sulfate versus esomeprazole impact on the neonates of preeclamptic rats.
Eur J Obstet Gynecol Reprod Biol. 2018 Jun; 225:236-242.EJ

Abstract

OBJECTIVE

Preeclampsia represents a major complication of pregnancy, associated with greater maternal and fetal complications. We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats.

STUDY DESIGN

Preeclampsia was induced in pregnant rats with NG-nitro-l-arginine methyl ester (L-NAME) starting from day 10-till end of pregnancy. Pregnant rats were divided into four groups: control pregnant; untreated preeclampsia; preeclamptic rats treated with MgSO4 and preeclamptic treated with esomeprazole. Treatment was started on day 14 and continued until end of pregnancy. Systolic blood pressure, gestation duration, the total number of pups/fetal resorption, pups birth weight, and histopathology examination of the pup's organs were recorded.

RESULTS

In comparison with the L-NAME group, the MgSO4 and esomeprazole treatment reduced the values of systolic blood pressure; MgSO4 normalized gestational duration while esomeprazole prolonged it (post-term pregnancy); both restored number of delivered pups; with no statistical differences between the numbers of died pups between the four groups studied while with esomeprazole, out of 10 pregnant females, 2 of them had complete intrauterine fetal resorption; esomeprazole normalized birth weight and histological structure of fetal liver, kidney, and brain. On the other side, MgSO4 treatment gave rise to lower than normal birth weight and minimal tissue damage.

CONCLUSION

Esomeprazole and MgSO4 improved systolic blood pressure, prevented preterm labor and restored numbers of pups delivered and fetal weight. Esomeprazole prolonged gestational period post-term with subsequent improving reproductive outcome.

Authors+Show Affiliations

Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Egypt. Electronic address: amaninabil@kasralainy.edu.eg.Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Egypt.Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Egypt.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29758543

Citation

Shafik, Amani N., et al. "Magnesium Sulfate Versus Esomeprazole Impact On the Neonates of Preeclamptic Rats." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 225, 2018, pp. 236-242.
Shafik AN, Khattab MA, Osman AH. Magnesium sulfate versus esomeprazole impact on the neonates of preeclamptic rats. Eur J Obstet Gynecol Reprod Biol. 2018;225:236-242.
Shafik, A. N., Khattab, M. A., & Osman, A. H. (2018). Magnesium sulfate versus esomeprazole impact on the neonates of preeclamptic rats. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 225, 236-242. https://doi.org/10.1016/j.ejogrb.2018.05.004
Shafik AN, Khattab MA, Osman AH. Magnesium Sulfate Versus Esomeprazole Impact On the Neonates of Preeclamptic Rats. Eur J Obstet Gynecol Reprod Biol. 2018;225:236-242. PubMed PMID: 29758543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnesium sulfate versus esomeprazole impact on the neonates of preeclamptic rats. AU - Shafik,Amani N, AU - Khattab,Mahmoud A, AU - Osman,Ahmed H, Y1 - 2018/05/08/ PY - 2018/01/15/received PY - 2018/05/04/revised PY - 2018/05/07/accepted PY - 2018/5/15/pubmed PY - 2018/10/12/medline PY - 2018/5/15/entrez KW - Esomeprazole KW - Histopathology KW - Magnesium sulfate KW - Neonate KW - Preeclampsia SP - 236 EP - 242 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 225 N2 - OBJECTIVE: Preeclampsia represents a major complication of pregnancy, associated with greater maternal and fetal complications. We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats. STUDY DESIGN: Preeclampsia was induced in pregnant rats with NG-nitro-l-arginine methyl ester (L-NAME) starting from day 10-till end of pregnancy. Pregnant rats were divided into four groups: control pregnant; untreated preeclampsia; preeclamptic rats treated with MgSO4 and preeclamptic treated with esomeprazole. Treatment was started on day 14 and continued until end of pregnancy. Systolic blood pressure, gestation duration, the total number of pups/fetal resorption, pups birth weight, and histopathology examination of the pup's organs were recorded. RESULTS: In comparison with the L-NAME group, the MgSO4 and esomeprazole treatment reduced the values of systolic blood pressure; MgSO4 normalized gestational duration while esomeprazole prolonged it (post-term pregnancy); both restored number of delivered pups; with no statistical differences between the numbers of died pups between the four groups studied while with esomeprazole, out of 10 pregnant females, 2 of them had complete intrauterine fetal resorption; esomeprazole normalized birth weight and histological structure of fetal liver, kidney, and brain. On the other side, MgSO4 treatment gave rise to lower than normal birth weight and minimal tissue damage. CONCLUSION: Esomeprazole and MgSO4 improved systolic blood pressure, prevented preterm labor and restored numbers of pups delivered and fetal weight. Esomeprazole prolonged gestational period post-term with subsequent improving reproductive outcome. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/29758543/Magnesium_sulfate_versus_esomeprazole_impact_on_the_neonates_of_preeclamptic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(18)30218-5 DB - PRIME DP - Unbound Medicine ER -