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The association between ambient PM2.5 exposure and the risk of preterm birth in China: A retrospective cohort study.
Sci Total Environ. 2018 Aug 15; 633:1453-1459.ST

Abstract

BACKGROUND

The relationship between PM2.5 exposure and preterm birth remains unclear.

OBJECTIVES

To explore the effect of exposure to PM2.5 on preterm birth in China.

METHODS

The birth outcomes of 426,246 pregnant women enrolled between January 2014 and December 2014 in NFPCP (National Free Pre-pregnancy Checkups Project) were collected, and their individual PM2.5 exposure values were estimated from the China National Environmental Monitoring Centre. The time of gestational exposure to PM2.5 was divided into four periods (the first trimester, the second trimester, the third trimester and the entire pregnancy). The average concentration and the corresponding quartiles of PM2.5 were calculated in these periods by the daily average PM2.5 data. Cox proportional hazards regression was used and he effects of maternal age, education level, occupation, second-hand smoking, alcohol use, pre-pregnancy BMI, baby's sex, number of previous pregnancies, coastal areas and season of conception were adjusted for.

RESULTS

A total of 426,246 singleton births were included, among which 35,261 (8.3%) were preterm birth. Effect of each 10μg/m3 increase of PM2.5 on preterm birth was most significant during the third trimester (HR, 1.06; 95%CI, 1.06-1.07), and also significant during the first trimester (HR, 1.04; 95%CI, 1.03-1.04), the second trimester (HR, 1.02; 95%CI, 1.02-1.02) and the entire pregnancy (HR, 1.06; 95%CI, 1.05-1.06). Compared with the lowest quartile of PM2.5, other quartiles increased the risk of preterm birth, and were most significant during the third trimester (HR, 1.87; 95%CI, 1.69-2.06). Subgroup analysis showed that compared with other subgroups, women who were older than 30years, had low education level, worked as farmers, had male baby, had previous pregnancies, not live in coastal areas and pregnant in winter were more sensitive to PM2.5 exposure.

CONCLUSIONS

Ambient PM2.5 exposure during pregnancy played an important role in the pregnancy process and increased the risk of preterm birth.

Authors+Show Affiliations

National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China.National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China; Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, China.National Research Institute for Family Planning, China.National Research Institute for Family Planning, China.National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China.Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, China.Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, China.National Research Institute for Family Planning, China.National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China.National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China.Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, China.Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, China.Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, China.National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China.National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China.National Research Institute for Family Planning, China.National Research Institute for Family Planning, China.National Research Institute for Family Planning, China; Graduate School of Peking Union Medical College, China; Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, China. Electronic address: NFPCC_ma@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29758897

Citation

Guo, Tongjun, et al. "The Association Between Ambient PM2.5 Exposure and the Risk of Preterm Birth in China: a Retrospective Cohort Study." The Science of the Total Environment, vol. 633, 2018, pp. 1453-1459.
Guo T, Wang Y, Zhang H, et al. The association between ambient PM2.5 exposure and the risk of preterm birth in China: A retrospective cohort study. Sci Total Environ. 2018;633:1453-1459.
Guo, T., Wang, Y., Zhang, H., Zhang, Y., Zhao, J., Wang, Q., Shen, H., Wang, Y., Xie, X., Wang, L., Xu, Z., Zhang, Y., Yan, D., He, Y., Yang, Y., Xu, J., Peng, Z., & Ma, X. (2018). The association between ambient PM2.5 exposure and the risk of preterm birth in China: A retrospective cohort study. The Science of the Total Environment, 633, 1453-1459. https://doi.org/10.1016/j.scitotenv.2018.03.328
Guo T, et al. The Association Between Ambient PM2.5 Exposure and the Risk of Preterm Birth in China: a Retrospective Cohort Study. Sci Total Environ. 2018 Aug 15;633:1453-1459. PubMed PMID: 29758897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between ambient PM2.5 exposure and the risk of preterm birth in China: A retrospective cohort study. AU - Guo,Tongjun, AU - Wang,Yuanyuan, AU - Zhang,Hongguang, AU - Zhang,Ya, AU - Zhao,Jun, AU - Wang,Qiaomei, AU - Shen,Haiping, AU - Wang,Yan, AU - Xie,Xiaoxu, AU - Wang,Long, AU - Xu,Zongyu, AU - Zhang,Yiping, AU - Yan,Donghai, AU - He,Yuan, AU - Yang,Ying, AU - Xu,Jihong, AU - Peng,Zuoqi, AU - Ma,Xu, Y1 - 2018/04/04/ PY - 2017/12/31/received PY - 2018/03/05/revised PY - 2018/03/26/accepted PY - 2018/5/16/entrez PY - 2018/5/16/pubmed PY - 2018/7/14/medline KW - Air pollution KW - Exposure period KW - PM2.5 KW - Preterm birth SP - 1453 EP - 1459 JF - The Science of the total environment JO - Sci. Total Environ. VL - 633 N2 - BACKGROUND: The relationship between PM2.5 exposure and preterm birth remains unclear. OBJECTIVES: To explore the effect of exposure to PM2.5 on preterm birth in China. METHODS: The birth outcomes of 426,246 pregnant women enrolled between January 2014 and December 2014 in NFPCP (National Free Pre-pregnancy Checkups Project) were collected, and their individual PM2.5 exposure values were estimated from the China National Environmental Monitoring Centre. The time of gestational exposure to PM2.5 was divided into four periods (the first trimester, the second trimester, the third trimester and the entire pregnancy). The average concentration and the corresponding quartiles of PM2.5 were calculated in these periods by the daily average PM2.5 data. Cox proportional hazards regression was used and he effects of maternal age, education level, occupation, second-hand smoking, alcohol use, pre-pregnancy BMI, baby's sex, number of previous pregnancies, coastal areas and season of conception were adjusted for. RESULTS: A total of 426,246 singleton births were included, among which 35,261 (8.3%) were preterm birth. Effect of each 10μg/m3 increase of PM2.5 on preterm birth was most significant during the third trimester (HR, 1.06; 95%CI, 1.06-1.07), and also significant during the first trimester (HR, 1.04; 95%CI, 1.03-1.04), the second trimester (HR, 1.02; 95%CI, 1.02-1.02) and the entire pregnancy (HR, 1.06; 95%CI, 1.05-1.06). Compared with the lowest quartile of PM2.5, other quartiles increased the risk of preterm birth, and were most significant during the third trimester (HR, 1.87; 95%CI, 1.69-2.06). Subgroup analysis showed that compared with other subgroups, women who were older than 30years, had low education level, worked as farmers, had male baby, had previous pregnancies, not live in coastal areas and pregnant in winter were more sensitive to PM2.5 exposure. CONCLUSIONS: Ambient PM2.5 exposure during pregnancy played an important role in the pregnancy process and increased the risk of preterm birth. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/29758897/The_association_between_ambient_PM2_5_exposure_and_the_risk_of_preterm_birth_in_China:_A_retrospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(18)31088-X DB - PRIME DP - Unbound Medicine ER -