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Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia.
J Pediatr Gastroenterol Nutr. 2018 Jun; 66 Suppl 3:S52-S55.JP

Abstract

BACKGROUND

A subset of children with functional gastrointestinal disorders (FGIDs), which includes functional dyspepsia, may have duodenal disaccharidase deficiencies.

OBJECTIVES

To determine the frequency, demographics, and clinical characteristics associated with duodenal disaccharidase deficiencies in children with functional dyspepsia.

METHODS

Children ages 4 to 18 years undergoing esophagogastroduodenoscopy (EGD) evaluation for dyspepsia were enrolled in either a retrospective (study 1) or prospective (study 2) evaluation. Those with histologic abnormalities were excluded. Duodenal biopsies were obtained for disaccharidase enzyme analysis. In the retrospective study, both demographic and clinical characteristics were obtained via chart review. In the prospective study, parents completed the Rome II Questionnaire on Gastrointestinal Symptoms before the EGD.

RESULTS

One hundred and twenty-nine children (n = 101, study 1; n = 28, study 2) were included. Mean age was 11.2 ± 3.8 (SD) years in study 1 and 10.6 ± 3.2 years in study 2. Forty-eight (47.5%) of subjects in study 1 and 13 (46.4%) of subjects in study 2 had at least 1 disaccharidase deficiency identified. All of those with a disaccharidase deficiency in both studies had lactase deficiency with 8 (7.9%) and 5 (17.9%) of those in studies 1 and 2, respectively, having an additional disaccharidase deficiency. The second most common disaccharidase deficiency pattern was that of pan-disaccharidase deficiency (PDD) in both studies. In study 1 (where both race and ethnicity were captured), self-identified Hispanic (vs non-Hispanic, P < 0.05) and non-white (vs white, P < 0.01) children were more likely to have lactase deficiency. Age, sex, and type of gastrointestinal symptom were not associated with presence or absence of a disaccharidase deficiency.

CONCLUSIONS

Approximately half of children with functional dyspepsia undergoing EGD were identified as having a disaccharidase deficiency (predominantly lactase deficiency). Race/ethnicity may be associated with the likelihood of identifying a disaccharidase deficiency. Other clinical characteristics were not able to distinguish those with versus without a disaccharidase deficiency.

Authors+Show Affiliations

Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine. Texas Children's Hospital.Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine. Texas Children's Hospital. USDA/ARS Children's Nutrition Research Center, Houston, TX.Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine. Texas Children's Hospital.Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine. Texas Children's Hospital.University of Buffalo, Department of Pediatrics, Buffalo, NY.Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine. Texas Children's Hospital. USDA/ARS Children's Nutrition Research Center, Houston, TX.Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine. Texas Children's Hospital. Children's Hospital of San Antonio, San Antonio, TX.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29762379

Citation

Chumpitazi, Bruno P., et al. "Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia." Journal of Pediatric Gastroenterology and Nutrition, vol. 66 Suppl 3, 2018, pp. S52-S55.
Chumpitazi BP, Robayo-Torres CC, Tsai CM, et al. Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia. J Pediatr Gastroenterol Nutr. 2018;66 Suppl 3:S52-S55.
Chumpitazi, B. P., Robayo-Torres, C. C., Tsai, C. M., Opekun, A. R., Baker, S. S., Nichols, B. L., & Gilger, M. A. (2018). Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia. Journal of Pediatric Gastroenterology and Nutrition, 66 Suppl 3, S52-S55. https://doi.org/10.1097/MPG.0000000000001859
Chumpitazi BP, et al. Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia. J Pediatr Gastroenterol Nutr. 2018;66 Suppl 3:S52-S55. PubMed PMID: 29762379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia. AU - Chumpitazi,Bruno P, AU - Robayo-Torres,Claudia C, AU - Tsai,Cynthia M, AU - Opekun,Antone R, AU - Baker,Susan S, AU - Nichols,Buford L, AU - Gilger,Mark A, PY - 2018/5/16/entrez PY - 2018/5/16/pubmed PY - 2019/4/24/medline SP - S52 EP - S55 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 66 Suppl 3 N2 - BACKGROUND: A subset of children with functional gastrointestinal disorders (FGIDs), which includes functional dyspepsia, may have duodenal disaccharidase deficiencies. OBJECTIVES: To determine the frequency, demographics, and clinical characteristics associated with duodenal disaccharidase deficiencies in children with functional dyspepsia. METHODS: Children ages 4 to 18 years undergoing esophagogastroduodenoscopy (EGD) evaluation for dyspepsia were enrolled in either a retrospective (study 1) or prospective (study 2) evaluation. Those with histologic abnormalities were excluded. Duodenal biopsies were obtained for disaccharidase enzyme analysis. In the retrospective study, both demographic and clinical characteristics were obtained via chart review. In the prospective study, parents completed the Rome II Questionnaire on Gastrointestinal Symptoms before the EGD. RESULTS: One hundred and twenty-nine children (n = 101, study 1; n = 28, study 2) were included. Mean age was 11.2 ± 3.8 (SD) years in study 1 and 10.6 ± 3.2 years in study 2. Forty-eight (47.5%) of subjects in study 1 and 13 (46.4%) of subjects in study 2 had at least 1 disaccharidase deficiency identified. All of those with a disaccharidase deficiency in both studies had lactase deficiency with 8 (7.9%) and 5 (17.9%) of those in studies 1 and 2, respectively, having an additional disaccharidase deficiency. The second most common disaccharidase deficiency pattern was that of pan-disaccharidase deficiency (PDD) in both studies. In study 1 (where both race and ethnicity were captured), self-identified Hispanic (vs non-Hispanic, P < 0.05) and non-white (vs white, P < 0.01) children were more likely to have lactase deficiency. Age, sex, and type of gastrointestinal symptom were not associated with presence or absence of a disaccharidase deficiency. CONCLUSIONS: Approximately half of children with functional dyspepsia undergoing EGD were identified as having a disaccharidase deficiency (predominantly lactase deficiency). Race/ethnicity may be associated with the likelihood of identifying a disaccharidase deficiency. Other clinical characteristics were not able to distinguish those with versus without a disaccharidase deficiency. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/29762379/Demographic_and_Clinical_Correlates_of_Mucosal_Disaccharidase_Deficiencies_in_Children_With_Functional_Dyspepsia_ L2 - http://dx.doi.org/10.1097/MPG.0000000000001859 DB - PRIME DP - Unbound Medicine ER -