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Influence of maternal adiposity, preterm birth and birth weight centiles on early childhood obesity in an Indigenous Australian pregnancy-through-to-early-childhood cohort study.
J Dev Orig Health Dis. 2019 02; 10(1):39-47.JD

Abstract

Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from the Gomeroi gaaynggal cohort, associations between prematurity, Gestation Related-Optimal Weight (GROW) centiles, maternal adiposity (percentage body fat, visceral fat area), maternal non-fasting plasma glucose levels (measured at mean gestational age of 23.1 weeks) and offspring BMI and adiposity (abdominal circumference, subscapular skinfold thickness) in early childhood (mean age 23.4 months). Maternal non-fasting plasma glucose concentrations were positively associated with infant birth weight (P=0.005) and GROW customized birth weight centiles (P=0.008). There was a significant association between maternal percentage body fat (P=0.02) and visceral fat area (P=0.00) with infant body weight in early childhood. Body mass index (BMI) in early childhood was significantly higher in offspring born preterm compared with those born at term (P=0.03). GROW customized birth weight centiles was significantly associated with body weight (P=0.01), BMI (P=0.007) and abdominal circumference (P=0.039) at early childhood. Our findings suggest that being born preterm, large for gestational age or exposed to an obesogenic intrauterine environment and higher maternal non-fasting plasma glucose concentrations are associated with increased obesity risk in early childhood. Future strategies should aim to reduce the prevalence of overweight/obesity in women of child-bearing age and emphasize the importance of optimal glycemia during pregnancy, particularly in Indigenous women.

Authors+Show Affiliations

1Priority Research Centre in Reproductive Sciences,University of Newcastle,Callaghan, NSW,Australia.1Priority Research Centre in Reproductive Sciences,University of Newcastle,Callaghan, NSW,Australia.3Gomeroi gaaynggal Centre, Faculty of Health and Medicine,University of Newcastle,Callaghan, NSW,Australia.3Gomeroi gaaynggal Centre, Faculty of Health and Medicine,University of Newcastle,Callaghan, NSW,Australia.3Gomeroi gaaynggal Centre, Faculty of Health and Medicine,University of Newcastle,Callaghan, NSW,Australia.5Adelaide Medical School and Robinson Research Institute,University of Adelaide,Adelaide,South Australia, Australia.6Aboriginal Health,Baker IDI Heart and Diabetes Institute,Melbourne, Victoria,Australia.7Aboriginal Research Unit,South Australian Health & Medical Research Institute,Adelaide,South Australia, Australia.1Priority Research Centre in Reproductive Sciences,University of Newcastle,Callaghan, NSW,Australia.1Priority Research Centre in Reproductive Sciences,University of Newcastle,Callaghan, NSW,Australia.4Department of Rural Health,University of Newcastle,Tamworth, NSW,Australia.9Priority Research Centre of Physical Activity and Nutrition,University of Newcastle,Callaghan, NSW,Australia.1Priority Research Centre in Reproductive Sciences,University of Newcastle,Callaghan, NSW,Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29764530

Citation

Pringle, K G., et al. "Influence of Maternal Adiposity, Preterm Birth and Birth Weight Centiles On Early Childhood Obesity in an Indigenous Australian Pregnancy-through-to-early-childhood Cohort Study." Journal of Developmental Origins of Health and Disease, vol. 10, no. 1, 2019, pp. 39-47.
Pringle KG, Lee YQ, Weatherall L, et al. Influence of maternal adiposity, preterm birth and birth weight centiles on early childhood obesity in an Indigenous Australian pregnancy-through-to-early-childhood cohort study. J Dev Orig Health Dis. 2019;10(1):39-47.
Pringle, K. G., Lee, Y. Q., Weatherall, L., Keogh, L., Diehm, C., Roberts, C. T., Eades, S., Brown, A., Smith, R., Lumbers, E. R., Brown, L. J., Collins, C. E., & Rae, K. M. (2019). Influence of maternal adiposity, preterm birth and birth weight centiles on early childhood obesity in an Indigenous Australian pregnancy-through-to-early-childhood cohort study. Journal of Developmental Origins of Health and Disease, 10(1), 39-47. https://doi.org/10.1017/S2040174418000302
Pringle KG, et al. Influence of Maternal Adiposity, Preterm Birth and Birth Weight Centiles On Early Childhood Obesity in an Indigenous Australian Pregnancy-through-to-early-childhood Cohort Study. J Dev Orig Health Dis. 2019;10(1):39-47. PubMed PMID: 29764530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of maternal adiposity, preterm birth and birth weight centiles on early childhood obesity in an Indigenous Australian pregnancy-through-to-early-childhood cohort study. AU - Pringle,K G, AU - Lee,Y Q, AU - Weatherall,L, AU - Keogh,L, AU - Diehm,C, AU - Roberts,C T, AU - Eades,S, AU - Brown,A, AU - Smith,R, AU - Lumbers,E R, AU - Brown,L J, AU - Collins,C E, AU - Rae,K M, Y1 - 2018/05/16/ PY - 2018/5/17/pubmed PY - 2020/3/24/medline PY - 2018/5/17/entrez KW - Indigenous KW - childhood obesity KW - maternal obesity KW - pregnancy KW - preterm birth SP - 39 EP - 47 JF - Journal of developmental origins of health and disease JO - J Dev Orig Health Dis VL - 10 IS - 1 N2 - Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from the Gomeroi gaaynggal cohort, associations between prematurity, Gestation Related-Optimal Weight (GROW) centiles, maternal adiposity (percentage body fat, visceral fat area), maternal non-fasting plasma glucose levels (measured at mean gestational age of 23.1 weeks) and offspring BMI and adiposity (abdominal circumference, subscapular skinfold thickness) in early childhood (mean age 23.4 months). Maternal non-fasting plasma glucose concentrations were positively associated with infant birth weight (P=0.005) and GROW customized birth weight centiles (P=0.008). There was a significant association between maternal percentage body fat (P=0.02) and visceral fat area (P=0.00) with infant body weight in early childhood. Body mass index (BMI) in early childhood was significantly higher in offspring born preterm compared with those born at term (P=0.03). GROW customized birth weight centiles was significantly associated with body weight (P=0.01), BMI (P=0.007) and abdominal circumference (P=0.039) at early childhood. Our findings suggest that being born preterm, large for gestational age or exposed to an obesogenic intrauterine environment and higher maternal non-fasting plasma glucose concentrations are associated with increased obesity risk in early childhood. Future strategies should aim to reduce the prevalence of overweight/obesity in women of child-bearing age and emphasize the importance of optimal glycemia during pregnancy, particularly in Indigenous women. SN - 2040-1752 UR - https://www.unboundmedicine.com/medline/citation/29764530/Influence_of_maternal_adiposity_preterm_birth_and_birth_weight_centiles_on_early_childhood_obesity_in_an_Indigenous_Australian_pregnancy_through_to_early_childhood_cohort_study_ L2 - https://www.cambridge.org/core/product/identifier/S2040174418000302/type/journal_article DB - PRIME DP - Unbound Medicine ER -