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Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer.
Ann Nucl Med 2018; 32(6):418-424AN

Abstract

OBJECTIVE

To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq).

PATIENTS AND METHODS

In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks. Thyroid-stimulating hormone-induced thyroglobulin (Tg) levels and I-131 uptake by the remnant thyroid tissue were also evaluated. A response-evaluation whole-body scan (WBS) was performed 6-8 months after RAI to determine the outcome of the therapy.

RESULTS

Post-LID urinary iodine levels of the strict LID group tended to be lower than those of the self-managed LID group. Twenty-five cases (56%) showed absence of uptake, whereas 20 cases (44%) showed residual uptake on the response-evaluation WBS. There were no significant differences between "absence" and "residual" groups in urinary iodine concentrations and Tg levels (p = 0.253 and p = 0.234, respectively). However, significant differences were observed in I-131 uptake by the thyroid bed (p = 0.035).

CONCLUSIONS

For patients following the current Japanese method of a 2-week LID, the urinary iodine concentration was not a predictive factor for the successful outcome of RAI. In contrast, low I-131 uptake by the thyroid bed, revealed by the scintigram after RAI, may serve as a favorable predictive factor.

Authors+Show Affiliations

Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. itoshj@med.nagoya-u.ac.jp.Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, 461-8673, Japan.Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29766463

Citation

Ito, Shinji, et al. "Predictive Factors for the Outcomes of Initial I-131 Low-dose Ablation Therapy to Japanese Patients With Differentiated Thyroid Cancer." Annals of Nuclear Medicine, vol. 32, no. 6, 2018, pp. 418-424.
Ito S, Iwano S, Kato K, et al. Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer. Ann Nucl Med. 2018;32(6):418-424.
Ito, S., Iwano, S., Kato, K., & Naganawa, S. (2018). Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer. Annals of Nuclear Medicine, 32(6), pp. 418-424. doi:10.1007/s12149-018-1261-0.
Ito S, et al. Predictive Factors for the Outcomes of Initial I-131 Low-dose Ablation Therapy to Japanese Patients With Differentiated Thyroid Cancer. Ann Nucl Med. 2018;32(6):418-424. PubMed PMID: 29766463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer. AU - Ito,Shinji, AU - Iwano,Shingo, AU - Kato,Katsuhiko, AU - Naganawa,Shinji, Y1 - 2018/05/15/ PY - 2018/03/07/received PY - 2018/05/07/accepted PY - 2018/5/17/pubmed PY - 2019/5/14/medline PY - 2018/5/17/entrez KW - Differentiated thyroid cancer KW - I-131 remmnant ablation KW - Low dose of I-131 KW - Low-iodine diet KW - Urinary iodine SP - 418 EP - 424 JF - Annals of nuclear medicine JO - Ann Nucl Med VL - 32 IS - 6 N2 - OBJECTIVE: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). PATIENTS AND METHODS: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks. Thyroid-stimulating hormone-induced thyroglobulin (Tg) levels and I-131 uptake by the remnant thyroid tissue were also evaluated. A response-evaluation whole-body scan (WBS) was performed 6-8 months after RAI to determine the outcome of the therapy. RESULTS: Post-LID urinary iodine levels of the strict LID group tended to be lower than those of the self-managed LID group. Twenty-five cases (56%) showed absence of uptake, whereas 20 cases (44%) showed residual uptake on the response-evaluation WBS. There were no significant differences between "absence" and "residual" groups in urinary iodine concentrations and Tg levels (p = 0.253 and p = 0.234, respectively). However, significant differences were observed in I-131 uptake by the thyroid bed (p = 0.035). CONCLUSIONS: For patients following the current Japanese method of a 2-week LID, the urinary iodine concentration was not a predictive factor for the successful outcome of RAI. In contrast, low I-131 uptake by the thyroid bed, revealed by the scintigram after RAI, may serve as a favorable predictive factor. SN - 1864-6433 UR - https://www.unboundmedicine.com/medline/citation/29766463/Predictive_factors_for_the_outcomes_of_initial_I_131_low_dose_ablation_therapy_to_Japanese_patients_with_differentiated_thyroid_cancer_ L2 - https://dx.doi.org/10.1007/s12149-018-1261-0 DB - PRIME DP - Unbound Medicine ER -