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Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity.
Endocr Res 2018; 43(4):275-283ER

Abstract

AIM OF THE STUDY

The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population.

METHODS

We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood. Serum FGF21 was measured during the first and third trimesters. Placentas were collected at delivery.

RESULTS

Maternal FGF21 concentrations were positively correlated with body mass index and adiposity, but not lean mass or glucose homeostasis. FGF21 concentrations significantly increased from the first to third trimester of pregnancy (0.105 vs. 0.256 ng/mL, p < 0.0001). Changes in FGF21 concentrations across pregnancy were not associated with changes in body weight or composition but inversely with the change in fasting glucose. FGF21 mRNA levels in placenta were very low and do not likely contribute to FGF21 in the maternal circulation.

CONCLUSIONS

FGF21 increases throughout pregnancy in our healthy cohort with overweight and obesity, independent of the placenta, and does not appear to be sensing the changes in energy balance (reflected in the change in maternal energy stores), but changes in macronutrient status. Thus, we propose FGF21 may be a potential signal of maternal nutrient status in pregnancy.

Authors+Show Affiliations

a Reproductive Endocrinology and Women's Health Laboratory , Pennington Biomedical Research Center-Louisiana State University , Baton Rouge , LA , USA.b Neurosignaling Laboratory , Pennington Biomedical Research Center-Louisiana State University , Baton Rouge , LA , USA.c Adipocyte Biology Laboratory , Pennington Biomedical Research Center-Louisiana State University , Baton Rouge , LA , USA.a Reproductive Endocrinology and Women's Health Laboratory , Pennington Biomedical Research Center-Louisiana State University , Baton Rouge , LA , USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29768065

Citation

Sutton, Elizabeth F., et al. "Fibroblast Growth Factor 21, Adiposity, and Macronutrient Balance in a Healthy, Pregnant Population With Overweight and Obesity." Endocrine Research, vol. 43, no. 4, 2018, pp. 275-283.
Sutton EF, Morrison CD, Stephens JM, et al. Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity. Endocr Res. 2018;43(4):275-283.
Sutton, E. F., Morrison, C. D., Stephens, J. M., & Redman, L. M. (2018). Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity. Endocrine Research, 43(4), pp. 275-283. doi:10.1080/07435800.2018.1473421.
Sutton EF, et al. Fibroblast Growth Factor 21, Adiposity, and Macronutrient Balance in a Healthy, Pregnant Population With Overweight and Obesity. Endocr Res. 2018;43(4):275-283. PubMed PMID: 29768065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibroblast growth factor 21, adiposity, and macronutrient balance in a healthy, pregnant population with overweight and obesity. AU - Sutton,Elizabeth F, AU - Morrison,Christopher D, AU - Stephens,Jacqueline M, AU - Redman,Leanne M, Y1 - 2018/05/16/ PY - 2019/11/01/pmc-release PY - 2018/5/17/pubmed PY - 2018/5/17/medline PY - 2018/5/17/entrez KW - FGF21 KW - obesity KW - placenta KW - pregnancy SP - 275 EP - 283 JF - Endocrine research JO - Endocr. Res. VL - 43 IS - 4 N2 - AIM OF THE STUDY: The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population. METHODS: We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood. Serum FGF21 was measured during the first and third trimesters. Placentas were collected at delivery. RESULTS: Maternal FGF21 concentrations were positively correlated with body mass index and adiposity, but not lean mass or glucose homeostasis. FGF21 concentrations significantly increased from the first to third trimester of pregnancy (0.105 vs. 0.256 ng/mL, p < 0.0001). Changes in FGF21 concentrations across pregnancy were not associated with changes in body weight or composition but inversely with the change in fasting glucose. FGF21 mRNA levels in placenta were very low and do not likely contribute to FGF21 in the maternal circulation. CONCLUSIONS: FGF21 increases throughout pregnancy in our healthy cohort with overweight and obesity, independent of the placenta, and does not appear to be sensing the changes in energy balance (reflected in the change in maternal energy stores), but changes in macronutrient status. Thus, we propose FGF21 may be a potential signal of maternal nutrient status in pregnancy. SN - 1532-4206 UR - https://www.unboundmedicine.com/medline/citation/29768065/Fibroblast_growth_factor_21_adiposity_and_macronutrient_balance_in_a_healthy_pregnant_population_with_overweight_and_obesity_ L2 - http://www.tandfonline.com/doi/full/10.1080/07435800.2018.1473421 DB - PRIME DP - Unbound Medicine ER -